DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment OGT and ogt-1

DIOPT Version :10

Sequence 1:NP_858058.1 Gene:OGT / 8473 HGNCID:8127 Length:1046 Species:Homo sapiens
Sequence 2:NP_001040860.1 Gene:ogt-1 / 176000 WormBaseID:WBGene00003858 Length:1151 Species:Caenorhabditis elegans


Alignment Length:1028 Identity:697/1028 - (67%)
Similarity:825/1028 - (80%) Gaps:19/1028 - (1%)


- Green bases have known domain annotations that are detailed below.


Human    24 LAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLL 88
            :.|||||::|:|::..||::|..:::.:|:|...|||||:|:||.:.|::|..:|.||||.|...
 Worm   128 VTELAHRQFQSGNYVEAEKYCNLVFQSDPNNLPTLLLLSAINFQTKNLEKSMQYSMLAIKVNNQC 192

Human    89 AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYN 153
            |||||||||.|||:||||:|:|:|:.|::|||:|||.|||||||||:.||:|.||.||.:|||.|
 Worm   193 AEAYSNLGNYYKEKGQLQDALENYKLAVKLKPEFIDAYINLAAALVSGGDLEQAVTAYFNALQIN 257

Human   154 PDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAV 218
            ||||||||||||||||:|||||||.||||||||||.|||||||||||||:|||||||||||||||
 Worm   258 PDLYCVRSDLGNLLKAMGRLEEAKVCYLKAIETQPQFAVAWSNLGCVFNSQGEIWLAIHHFEKAV 322

Human   219 TLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYR 283
            |||||||||||||||||||||||||||:||||||:||.||||||||||||||||||||||||||:
 Worm   323 TLDPNFLDAYINLGNVLKEARIFDRAVSAYLRALNLSGNHAVVHGNLACVYYEQGLIDLAIDTYK 387

Human   284 RAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVR 348
            :||:||||||||||||||||||||||.|||..|..||.||||||||.|||||||||||.||:|.|
 Worm   388 KAIDLQPHFPDAYCNLANALKEKGSVVEAEQMYMKALELCPTHADSQNNLANIKREQGKIEDATR 452

Human   349 LYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQG 413
            ||.||||::||||||||||||:|||||||.:|::||||||||:|||||||||||||||||.|...
 Worm   453 LYLKALEIYPEFAAAHSNLASILQQQGKLNDAILHYKEAIRIAPTFADAYSNMGNTLKEMGDSSA 517

Human   414 ALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCD 478
            |:.||.||||||||||||||||||||||:||:.|||.||.|||||||||||||||||||.||:||
 Worm   518 AIACYNRAIQINPAFADAHSNLASIHKDAGNMAEAIQSYSTALKLKPDFPDAYCNLAHCHQIICD 582

Human   479 WTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINV--LHKP 541
            |.|||:|::|||.||.|||.|.|||||||||||||||||..|.|||.:|.:||.||::|  |.|.
 Worm   583 WNDYDKRVRKLVQIVEDQLCKKRLPSVHPHHSMLYPLSHAARIAIAAKHASLCFDKVHVQMLGKT 647

Human   542 PYEHPKDLKLSDG-RLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKV 605
            |..|.....:.:| |||:|||||||||||||||||||||||:..:.||||||||.:||||||.|:
 Worm   648 PLIHADRFSVQNGQRLRIGYVSSDFGNHPTSHLMQSIPGMHDRSRVEVFCYALSVNDGTNFRSKL 712

Human   606 MAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSG 670
            |.|:.||:||||||||||||::|.|||||||:||||||||||||:|||||||||.||||||.|||
 Worm   713 MNESEHFVDLSQIPCNGKAAEKIAQDGIHILINMNGYTKGARNEIFALRPAPIQVMWLGYPSTSG 777

Human   671 ALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIV 735
            |.||||||||..|||..:|..::||||||||||||||||.|..||..|.|:..|.... .|:.::
 Worm   778 ATFMDYIITDAVTSPLRLANAFTEKLAYMPHTFFIGDHAQMLRHLTDKVVVKDKETTE-RDSCLI 841

Human   736 LNGIDLKAFL------DSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMINRGQ 794
            :|..::...|      :.:.|.::|      .|.|.:.....:.:||:.:.|  |.:.:||..||
 Worm   842 MNTANMDPILAKSEIKEQVLDTEVV------SGPNKELVRAEMVLPVLEVPT--EPIKQMIMTGQ 898

Human   795 IQITI-NGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTL 858
            :.:.: ...::.|||..:|:::|||||||:|.::::|:|:||.||:||||:||||||||||||||
 Worm   899 MTMNVMEDMNVQNGLGQSQMHHKAATGEEIPNSVLLTSRAQYQLPDDAIVFCNFNQLYKIDPSTL 963

Human   859 QMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLD 923
            .||..||:.||.|:|||||||..||.:|::|....||..:||:||.||.||||||||||||||||
 Worm   964 DMWIKILENVPKSILWLLRFPYQGEEHIRKYCVERGLDPSRIVFSNVAAKEEHVRRGQLADVCLD 1028

Human   924 TPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLE 988
            ||||||||||||:||.||||||||.|:||||||.|||..||..||:||.||||..|||:||||.:
 Worm  1029 TPLCNGHTTGMDILWTGTPMVTMPLESLASRVATSQLYALGVPELVAKTRQEYVSIAVRLGTDAD 1093

Human   989 YLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIKPVE 1041
            :|..:|.|||..|.||.||:.|||..::|.|..|||:.|.:|...||:....|
 Worm  1094 HLANMRAKVWMARTSSTLFDVKQYCHDMEDLLGQMWKRYESGMPIDHITNNTE 1146

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OGTNP_858058.1 TPR 1 21..54 11/29 (38%)
TPR repeat 24..49 CDD:276809 10/24 (42%)
PilF 32..121 CDD:442297 45/88 (51%)
TPR repeat 57..83 CDD:276809 13/25 (52%)
TPR 82..289 CDD:440225 173/206 (84%)
TPR 2 89..122 23/32 (72%)
TPR repeat 89..117 CDD:276809 20/27 (74%)
TPR repeat 122..152 CDD:276809 21/29 (72%)
TPR 3 123..156 23/32 (72%)
TPR 4 157..190 30/32 (94%)
TPR repeat 157..185 CDD:276809 25/27 (93%)
LapB 190..457 CDD:442196 228/266 (86%)
TPR 5 191..224 31/32 (97%)
TPR repeat 191..219 CDD:276809 26/27 (96%)
TPR 6 225..258 29/32 (91%)
TPR repeat 226..253 CDD:276809 25/26 (96%)
TPR 7 259..292 29/32 (91%)
TPR repeat 259..287 CDD:276809 25/27 (93%)
TPR 8 293..326 26/32 (81%)
TPR repeat 293..321 CDD:276809 22/27 (81%)
TPR 9 327..360 25/32 (78%)
TPR repeat 327..355 CDD:276809 22/27 (81%)
TPR repeat 360..390 CDD:276809 24/29 (83%)
TPR 10 361..394 26/32 (81%)
TPR 11 395..428 25/32 (78%)
TPR repeat 395..423 CDD:276809 20/27 (74%)
TPR 12 429..462 27/32 (84%)
TPR repeat 429..457 CDD:276809 22/27 (81%)
TPR 13, truncated 463..473 9/9 (100%)
DFP motif. /evidence=ECO:0000269|PubMed:27713473 464..466 1/1 (100%)
Glyco_transf_41 476..1016 CDD:404688 333/549 (61%)
Nuclear localization signal. /evidence=ECO:0000255 487..503 10/15 (67%)
Required for phosphatidylinositol 3,4,5-triphosphate binding. /evidence=ECO:0000250|UniProtKB:P56558 991..1010 9/18 (50%)
ogt-1NP_001040860.1 NrfG 130..231 CDD:443378 54/100 (54%)
TPR repeat 130..153 CDD:276809 10/22 (45%)
TPR 184..393 CDD:440225 175/208 (84%)
TPR repeat 193..221 CDD:276809 20/27 (74%)
TPR repeat 226..256 CDD:276809 21/29 (72%)
TPR repeat 261..289 CDD:276809 25/27 (93%)
LapB 294..561 CDD:442196 228/266 (86%)
TPR repeat 295..323 CDD:276809 26/27 (96%)
TPR repeat 330..357 CDD:276809 25/26 (96%)
TPR repeat 363..391 CDD:276809 25/27 (93%)
TPR repeat 396..426 CDD:276809 24/29 (83%)
TPR repeat 431..459 CDD:276809 22/27 (81%)
TPR repeat 465..493 CDD:276809 22/27 (81%)
TPR repeat 498..528 CDD:276809 22/29 (76%)
TPR repeat 533..561 CDD:276809 22/27 (81%)
Glyco_transf_41 580..1121 CDD:404688 333/549 (61%)

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