Protein Alignment PIGO and CG4907

DIOPT Version :10

• Sequence 1: NP_116023.2
• Gene: PIGO / 84720
• HGNCID: 23215
• Length: 1089
• Species: Homo sapiens
• Sequence 2: NP_651086.1
• Gene: CG4907 / 42686
• FlyBaseID: FBgn0039010
• Length: 919
• Species: Drosophila melanogaster
• Alignment Length: 1005
• Identity: 198/1005 - (19%)
• Similarity: 339/1005 - (33%)
• Gaps: 329/1005 - (32%)

Human     7 LLFLAWVCFLFYAGIALFTSGFLLTRLELTNHSSCQEPPGPGSLPWGSQGKPGACWMASRFSRVV 71
            ||.|..:..:::....|.....|.|..||.     .|||.                     .|:|
  Fly    11 LLLLGSILSIYFQSTILSDLEPLSTLRELG-----LEPPA---------------------DRLV 49

Human    72 LVLIDALRFDFAQPQHSHVPREPPVSLPFLGKLSSLQRILEI---------QPHHARLYRSQVDP 127
            :.::|.||.......|..       ::|.|.:|...|.::.|         :|.|..::....:.
  Fly    50 VFVVDGLRAQSVLADHCS-------AVPDLRELFVEQALVGISRACPPTVTRPGHIAIFGGFNED 107

Human   128 PTTTMQRLKALTTGSLPTFIDAGSNFASHAI--VEDNLIK---QLTSAGRRVVF-------MGD- 179
            |..|      ||..  |:..|:..|.:.:||  ::..:.|   .|.:.|..:.|       :.|
  Fly   108 PAAT------LTWN--PSTFDSVFNRSRNAIGWMQAEVAKVFTHLPTGGAPLRFETFARSDISDR 164

Human   180 ---DTWKDLFPGAFSKAFFFPSFNVRDLDTVDNGILEHLYPTMDSGEWDVLIAHFLGVDHCGHKH 241
               |.|      .|.|        ||:..|.:    :::.|..|:.. .:...:...:|...|.|
  Fly   165 LRLDQW------TFDK--------VRNFMTNE----QNVQPLRDATS-VIFFVYLADIDLAEHVH 210

Human   242 GPHHPEMAKKLSQMDQVIQGLVERLE---ND--TLLVVAGDHGMTTNGDHGGDSELEVSAALFLY 301
            .|:.....:||:...:.|:...|..|   ||  |..::..|:|::.   |||..|..|.....|:
  Fly   211 MPNSLNFREKLNYTQRGIRQTYELFESVFNDSRTAYLMTADYGISL---HGGGGERGVETPFILW 272

Human   302 -------SPTAVFPSTPPEEPEVIP-----QVSLVPTLALLLGLPIPFGNIGEVMAELFSGGEDS 354
                   :|......|..|...::|     |:.|.|.::.|:|||.|..|:..:.....
  Fly   273 GAGVKRSAPNPGQNFTAGENGPILPLYQLEQIQLAPLMSALIGLPPPMNNMALMPLGFL------ 331

Human   355 QPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKELHQLQNLFSKASADYQWLL----QSPK 415
              ::|...:...|||||.|:                  |.|.:.|..:......:||    :|..
  Fly   332 --NTSVQYELQVLHLNAMQL------------------LAQARILIKRHEDGILYLLLPKFESLG 376

Human   416 GAE-ATLPTVIAELQQFLRGARAMCIESWARFSLVRMAGGTALLAASCFICLLASQWAISPGFPF 479
            .|| ...|.:|..|.     |:....|:      ::::...|.||..|.        ....|:..
  Fly   377 SAEIENYPQIIKYLV-----AKEQYEEA------LKVSHKIAKLAQECM--------EYYHGYYH 422

Human   480 CPLLLTPVAWGLV---------------------GAIAYAGL---LGTIELKLDLVLLGAVAAVS 520
            .|||:...|..||                     |.:.:..|   ||.:.| |:|::|..|..::
  Fly   423 LPLLVATTASYLVWFYLLLVRLARESNHPKSERKGYLTWTTLMMCLGGLVL-LELMILQRVPHLT 486

Human   521 SF---LPF--LWKAWAGWGSKRP-----LATLFPI--------PGPVLLLLLFRLA--------- 558
            :|   |||  |..|.|    :||     |...||:        ||.:|:|:.|..:
  Fly   487 AFYLLLPFGILILALA----ERPCQDRDLMCQFPVLHLVGIVMPGVLLILMAFHNSHIGLLYLPI 547

Human   559 -------VFFSDSFVVAEARATPFLLGSFILLLVVQ---LHWEGQLLPPKLLTMPRLGTSATTNP 613
                   .||..|..:....|..|||..  :|||.|   ||:....:
  Fly   548 VCLNNRRAFFRPSLKLIFWLALVFLLSG--ILLVKQSASLHFITDTI------------------ 592

Human   614 PRHNGAYALRLGIGLLLCTRLAGLFHRCPEETPVCHSSPWLSPLASMVGG--RAKNLWYGACVAA 676
                |.|     ||                .:.|.:.|..||.:..::.|  .:..:|. ..:||
  Fly   593 ----GVY-----IG----------------NSHVVYFSMILSIIRPLILGHQHSTRVWI-VNMAA 631

Human   677 LVALLAAVRLWLRRYGNLKSPEPPMLFVR---WGLPLMALGTAAYWALASGADEAPPRLRVLVSG 738
            |:.....:..|       .:.:|...:|.   |...|.|..:..|    ||..:...||.:::
  Fly   632 LLVTAYGIYQW-------DADQPVCTYVYAACWSYLLFAFLSIPY----SGTKDLRRRLELII-- 683

Human   739 ASMVLPRAVAGLAASGLALLLWKPVTVLVKAGAGAPRTRTVLTPF-SGPPTSQADLDYV-VPQIY 801
            .:|:                   .|.:::....|:...:.::|.| .|....:....|. :....
  Fly   684 FNML-------------------TVHIMLTTSIGSLFVQIMVTEFVLGLELYEESFSYANLKDAI 729

Human   802 RHMQEEFRGRLERTKSQGPLTVAAYQLGSVYSAAMV---------------------TALTLLAF 845
            .:.|:..:| ||.::::.|.....:...|...||::                     ...:.|.|
  Fly   730 ANQQQNNQG-LEESRNESPNNPLEHVRQSYRYAALILLYLYISFFGTGHWFFNFTFKPMTSRLFF 793

Human   846 PLLLLHAERISLVFLLLFLQSFLLLHLLAA 875
            |...||. .::.:.|.:|:.|.:::..:.|
  Fly   794 PQFHLHM-LVAFILLKIFIPSIIVMSSIYA 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIGO	NP_116023.2	GPI_EPT_3	65..344	CDD:293747	69/320 (22%)
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	72/342 (21%)
		PigN	412..858	CDD:461508	95/504 (19%)