Protein Alignment PIGO and CG5342

DIOPT Version :10

• Sequence 1: NP_116023.2
• Gene: PIGO / 84720
• HGNCID: 23215
• Length: 1089
• Species: Homo sapiens
• Sequence 2: NP_650088.2
• Gene: CG5342 / 41389
• FlyBaseID: FBgn0037916
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 819
• Identity: 155/819 - (18%)
• Similarity: 254/819 - (31%)
• Gaps: 318/819 - (38%)

Human   296 AALFLYSPTAVFPSTPPEEPEVIPQVSLVPTLALLL--GLP-----------IPFGNIGEVMAEL 347
            |.:.:|..:....|..|:|.|.:.:......|.:|:  ||.           :|      ::.||
  Fly    18 AVVLIYLRSTYPGSLEPQEVEHLKEPPPADRLVVLVRDGLSAQSFLANRCTNVP------LLREL 76

Human   348 FSGGEDSQPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKEL------HQLQNLFSKASAD 406
            |.       |...:..:....:....:|.::..:|...:|..:...      ..:.::|.:....
  Fly    77 FL-------HQGLVGISRPETITYHSISPYISLFSGFNEDAASVARGWLGTPASIDSIFDRCKRS 134

Human   407 YQWL----------LQSPKGAEATLPTV-------IAELQQFLRGARAMCIESWARFSLVRMAGG 454
            :.|.          ::.|:  |.:..|.       .:|::.|      :| .|..||    :.||
  Fly   135 FAWTTTELISRFPKIERPR--ELSFETYGEGVTKSCSEMEDF------VC-RSVQRF----LGGG 186

Human   455 TALLAASCFICLLASQWAISPGFPFCPLL--LTPVAWGLV-----------GAIAYAGLLGTIEL 506
            :.||..:..:........:.|.   |..|  :....|.:.           .|..:...||..:.
  Fly   187 SRLLLNTTGVIFFIHMTGVEPS---CESLQRIQENVWNVYKSFEKTFPDQRTAYLFTSNLGDPQT 248

Human   507 KLDLVLLGAVAAVSSFLPFLW-------KAWAG-------WGSKRPL------------ATLFPI 545
            |.:.    ::|..|.|  |||       |:..|       .|.:.||            :.|..:
  Fly   249 KSEY----SLAVESPF--FLWGSGVNHIKSMPGRSFMANEAGLRLPLHVLNTPHLTALMSALLGV 307

Human   546 PGPV---------LLLLLFRL---AVFFSDSFVVAEARATPFL--------------LGSFI--- 581
            |.||         :|....|.   |:..:...::|:||....|              :.:|:
  Fly   308 PPPVYSRGMLPKGMLNASLRYEANAMLINAKQLLAQARRLRELHPKRMPAFWLSFQMMDNFVKES 372

Human   582 LLLVVQLHWEGQLLPPKLLTMPRL--GTSATTNPPRHNGAYALRL-GIGLLLCTRLAGLFHRCPE 643
            |.|..|..:.. ||......||.|  |.....:..||....|:.. ||..:.|.|
  Fly   373 LALKKQRRFRA-LLDYSCNYMPVLIKGMDYFKDYYRHVSITAVSFAGIAWIYCLR---------- 426

Human   644 ETPVCHSSPWLSPLASMVGGRAKNL-----------------WYGACVAALV------------- 678
                ||.:         ||.:.:||                 ::......||
  Fly   427 ----CHLT---------VGKKCRNLIEIQEVISSKRLVYARGFHRLLTGVLVIIMMLERIPLVVQ 478

Human   679 ALLAAVRLWLRRYGNLKSPEPPML-------------------FVRWGLPLMALGTAAY------ 718
            |:|....|:.|....:....|.|:                   |.|:.|.:..||.|:|
  Fly   479 AILLIPSLYWRTTLKILGERPKMVCRKSLMSTALLALICFGGFFRRYILAVGYLGFASYNNREAF 543

Human   719 ---------WALASGADEAPPRLRVLVSGASMV--LPRAVAGLAASGLALLLWKPVTVLVKAGAG 772
                     |.|             |:.|.::|  ||.:: |.:..| ||:....:|||.....|
  Fly   544 KRRGHQFYLWLL-------------LLLGLTVVSALPESL-GCSQPG-ALMFSIFLTVLRPLACG 593

Human   773 APRTRTVLTPFSGPPTSQADLDYV-----------VPQIY---------RHMQ--EEF------- 808
            .  ...:||..|..|...|.|:|:           |..||         |::|  |.|
  Fly   594 V--YLNLLTWLSNIPVLLAALEYILIGWHPWIMYLVSWIYLGFLVLWQRRNLQASEVFFFDLSTL 656

Human   809 ------------------------RGRLERTKSQGPLTVAAYQLGSVYSAAMVTALTLLAFP--- 846
                                    |.:|:|.:|.||.|.|.|.|  |||  ..:...:.:||
  Fly   657 YTLTCTSYESVVIQMLAMELQLALRMKLKRNESIGPKTAAHYIL--VYS--WYSLFIIGSFPAFD 717

Human   847 --LLLLHAE-------RISLVFLLLFLQSFLLLHLLAAG 876
              |.:||..       ...||.:|..:..:||:..:.||
  Fly   718 DFLDILHETCFGYSPLTYGLVMVLKLILPWLLVLCIMAG 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIGO	NP_116023.2	GPI_EPT_3	65..344	CDD:293747	11/60 (18%)
CG5342	NP_650088.2	GPI_EPT_1	43..318	CDD:293744	50/309 (16%)
		PigN	397..781	CDD:461508	83/404 (21%)