Protein Alignment IRS4 and irs4

DIOPT Version :10

• Sequence 1: NP_001427746.1
• Gene: IRS4 / 8471
• HGNCID: 6128
• Length: 1300
• Species: Homo sapiens
• Sequence 2: NP_001135469.1
• Gene: irs4 / 100196925
• XenbaseID: XB-GENE-479893
• Length: 1077
• Species: Xenopus tropicalis
• Alignment Length: 1294
• Identity: 404/1294 - (31%)
• Similarity: 552/1294 - (42%)
• Gaps: 347/1294 - (26%)

Human    50 CP----GAMWLSTATGSRSDSES--EEEDLPVG-----EEVCKRGYLRKQKHGHRRYFVLKLETA 103
            ||    |...:|..|.|:...|.  |....|:.     ::|.||||||||||||:|||||:.::.
 Frog    25 CPDESGGYRRMSGPTLSQVQEEPAVEPPQPPLAASSAEDDVRKRGYLRKQKHGHKRYFVLRSQSH 89

Human   104 DAPARLEYYENARKFRHSVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLI 168
            ..|||||||:|.:|||...|:..                .|:|||.||.||:.|:||||:.:||:
 Frog    90 LGPARLEYYDNEKKFRSGQRSGC----------------HPKRVIPLYLCFTASRRADAKNKHLV 138

Human   169 ALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKD 233
            ||:|:||||||.||:|.||::||..||.||.|||       ||..|.|..............:|:
 Frog   139 ALYTKDEYFAMAAESEQEQDAWYQALSELINESK-------GACLDTEELEENYGTLRPGTVFKE 196

Human   234 VWQVIVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGR 298
            ||||.|||||||..|.||||:||||:.:.|..|:||::||.|.:.|::||||||||.|||:||||
 Frog   197 VWQVNVKPRGLGQAKNLSGVYRLCLSSKAVHLVKLNSDVACVHLLLMNIRRCGHSENYFFIEVGR 261

Human   299 STVIGPGELWMQVDDCVVAQNMHELFLEKMRALCA-DEYRARCRSYSISIGAHLLTLLSARRHLG 362
            |:..|.||||||||||||||:|||.|||.|:||.| .|:|.|.:|.  |.|.:.::.::.||:||
 Frog   262 SSSTGAGELWMQVDDCVVAQHMHETFLETMKALKAYSEFRPRSKSQ--SSGTNPISFITTRRYLG 324

Human   363 LVPLEPGGWLRRSRFEQFC-----------HLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHL 416
            .:|....|..||||.|...           ..|...:||..|  ||.|.:.:..::|....|::|
 Frog   325 NLPPSQTGLQRRSRTESVVGTPPSAKNNSFRFRTSSEGEGTM--TRPFRSVTGSLSHLNTARINL 387

Human   417 PR----GRRSR---------RAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNF 468
            .:    ||..|         |:.|:|.|.|    ||...|             .|..|.||.|:.
 Frog   388 GKQEGAGRYVRAPFNSGYHSRSASLPVSHF----PSATSP-------------ISVCSSSGHGSA 435

Human   469 GEEGNPQGKEDQEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQ 533
            .|...........||..|               ||...|:..|||         .|:.:..|  .
 Frog   436 SETLTRPSSSSVCGSPSD---------------GGFISSDEYGSS---------PGDLRYFR--V 474

Human   534 GSNGQGSGGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGK 598
            .||...|.||......:.|...:.|                  ...|.....|
 Frog   475 RSNTPDSLGNTPPIQEENTLSDYMS------------------MSTHSHPDSK------------ 509

Human   599 GSDGDGERGKSLKKRSY-FGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVDRG 662
              |...|..|..:||:| ..|.|.|..||                     ||.....|    |..
 Frog   510 --DDYMEADKCFRKRTYSLTKPTNSASQQ---------------------KSQAAISL----DED 547

Human   663 ATKECK-----EAKEVKDAEIPEGAARG-------PHRARAFDEDEDDPYVPMRPGVATPLVSSS 715
            :.:..|     |:.::||:...|..:.|       ..|::|    .||.|:||.|..:    ..|
 Frog   548 SEEINKQFAYAESPKLKDSSHVEDYSNGIIDSVCNHSRSKA----SDDGYMPMMPSNS----YDS 604

Human   716 DYMPMAPQNVSASKKRHSRSPFE-DSRGYMMMFPRVSPPPAPSPPK------APDTNKEDDSKDN 773
            ||:||||:.||| .|:.:|.|.: ||:|||||||..|     ||.|      |..:|.|     .
 Frog   605 DYLPMAPKTVSA-PKQINRCPSQGDSKGYMMMFPINS-----SPVKNVFGGAATKSNIE-----K 658

Human   774 DSESDYMFMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPM-LPGKFL 837
            .|...||.|:.|......|..|....::|:..|||||||..|::......|::||||| .|||.|
 Frog   659 LSNGGYMDMSYGNSIKQINDSNVTNNNNSRGLSSYFSLPRSFKNLTKQNIDHNEYVPMSSPGKLL 723

Human   838 ------GRGLDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFIT 896
                  |.|:.||.:.| |......|.||                   .....:.|||.:|:...
 Frog   724 HLGAENGVGVCKEGAVN-DIAKTELKSSG-------------------NILDQQVKRPTKLTLGI 768

Human   897 KGYKIKPK------PQKPTHEQREADSSSDYVNMDFTKRESNTP-APSTQGLPDSWGIIAEPRQS 954
            :|....|:      |.:||       |..:|:|:||:.:.|:|| :.|.:|.|.|.|...:.|||
 Frog   769 RGSNTIPRMFDHSAPAEPT-------SPGEYINIDFSDKASSTPYSLSAEGSPSSLGSSCDHRQS 826

Human   955 AFSNYVNVEFGVPFPNPANDLSDLL--------RAIPRANPLSLDSARWPLPPLPLSATGSNAIE 1011
            ..|:|::|:..|..|....:||:.|        ..:.|..| :.|.|:.|.....:|.| .|.|:
 Frog   827 PLSDYMSVDIDVQSPKATAELSNSLTDISSYACTVVSRMQP-NADYAKLPCGTACVSKT-DNRID 889

Human  1012 EEGDYIEVIFNSAMTPAMALADSAIRYDAETGRIYVVDPFSE-----CCMDISLSPSRCSEPPPV 1071
               ||..:.||.||||..:.|       :||.....||..|.     |..|::...|..|.|.|:
 Frog   890 ---DYTTMTFNMAMTPPRSFA-------SETENGTKVDSPSSIVNRLCIGDMTSLNSGFSLPNPL 944

Human  1072 ------ARLLQEEEQERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLAL 1130
                  .::::.::|.|||..|.:.|..:....:.|.| |:|
 Frog   945 PEPIAGPKVIRADQQGRRRHSSETFSSASTVTTSSSCF-TES----------------------- 985

Human  1131 SQVVAAASALAAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSAN 1195
                            |...::|.||:.   |.:|..|:.:       ||     |..:.|.|..
 Frog   986 ----------------GKRHSSASFDNV---WLKPDENSCE-------QD-----NKMSRNCSTG 1019

Human  1196 LARGDNQAG-----GAA--AAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRD 1247
            ...|.|...     |..  |:.|..:....||.:           :...:|.:||.|.|
 Frog  1020 FQNGLNYIALSMHDGVCEPASTACHQHQNGSRNL-----------ESGGYVSIDFTRSD 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IRS4	NP_001427746.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	406..653		53/260 (20%)
		YXXM motif 1	487..490		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	678..921		84/269 (31%)
		CRK-binding	678..800		46/135 (34%)
		YXXM motif 2	700..703		1/2 (50%)
		YXXM motif 3	717..720		1/2 (50%)
		YXXM motif 4	743..746		2/2 (100%)
		YXXM motif 5	779..782		2/2 (100%)
		YXXM motif 6	828..831		2/2 (100%)
		GRB2-binding	895..897		0/1 (0%)
		YXXM motif 7	921..924		1/2 (50%)
irs4	NP_001135469.1	PH_IRS	63..172	CDD:269959	66/124 (53%)
		PTB_IRS	194..296	CDD:269915	69/101 (68%)