Protein Alignment LNX1 and lnx1

DIOPT Version :10

• Sequence 1: NP_001119800.1
• Gene: LNX1 / 84708
• HGNCID: 6657
• Length: 728
• Species: Homo sapiens
• Sequence 2: XP_005160562.1
• Gene: lnx1 / 561226
• ZFINID: ZDB-GENE-030131-9439
• Length: 769
• Species: Danio rerio
• Alignment Length: 752
• Identity: 452/752 - (60%)
• Similarity: 559/752 - (74%)
• Gaps: 41/752 - (5%)

Human    10 PEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDF 74
            |..||.:|||.|..||||.|:|.|:|||||:||||||.|:.|||||||||||..||||||:|.||
Zfish    26 PPDLCHICGQRHLQEENHEYTYKEDVDDDLMCHICLQPLIRPLDTPCGHTYCQECLTNFLLESDF 90

Human    75 CPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQTSCKGASHYGLTKD 139
            ||:||.||:||.|:|||:||:|||:||:|:|||.:|||:|:.|.::|.|.:..|||||||||:.:
Zfish    91 CPVDRTPLMLQKCRKSSLLVHKLLDKLMVSCPFADHCTEVMPRGEMEGHIRCRCKGASHYGLSAE 155

Human   140 RKRRSQDG-CPDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVD---- 199
            ||||||:| |.|..:.||..|...|...::.|:|::|||||.||||..|.||...:.|...
Zfish   156 RKRRSQEGDCTDSTSELTLAALPGEGCPSSAIALLSDEPGLVNPAYEPSVEDNSQSGSTTSLAAR 220

Human   200 SGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAP---EVF- 260
            || |.::..|.|:|:::|||||:::|||.|||||||||:||||...:.|:|..|...|   |:|
Zfish   221 SG-SRKSEYRNFDRTSVRSRSFRRLNRAFSVLRRTKSGTAVANDTTEERDNLRNANIPAEGELFA 284

Human   261 -PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDII 324
             |:|:|||||||:|||||.|.||.|.|:|.:|||:|||||.|:||.|||:|||||||||||||:|
Zfish   285 LPQLHHLIPDGEVTSIKITRADPCEPLAISIVGGNETPLVRILIQDIYREGVIARDGRLLPGDMI 349

Human   325 LKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRP------RDDSFHVI 383
            |||||:|||||||.|||..|:|||.:|.|||:|||:.|.|::..:|....|      ||||.||:
Zfish   350 LKVNGIDISNVPHCYAVAALKQPCTLLRLTVLREQRHRYRSHHHSPTEAFPAHTATIRDDSLHVV 414

Human   384 LNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHL 448
            |.|.:|:|||||||||:.||.|||||::|:||:|.|.|:|..:||||||||||||||:||.||.|
Zfish   415 LVKRAPDEQLGIKLVRRPDEHGVFIFHLLEGGLAARDGRLRVDDRVLAINGHDLRYGAPEHAALL 479

Human   449 IQASERRVHLVVSRQVRQRSPDIFQEAGWNSNG--SWSPGPGERS---NTPKPLHPTITCHEKVV 508
            |||||.|||.:||||....:|||.|||.||..|  .:||...|.:   :..||     .|:||.|
Zfish   480 IQASEDRVHFIVSRQTHIPAPDILQEAPWNMEGPPPYSPVDIEHTLLDSCQKP-----ACYEKTV 539

Human   509 NIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSE 573
            .:.|:|.:|||||||||.|.|.||||:||.:|:|.||:.::|.|:.|||||||:||:||.|:|||
Zfish   540 TLLKEPHDSLGMTVAGGMSSRGWDLPVYVTNVDPNGVVGQEGSIRKGDILLNVNGVDLTGVTRSE 604

Human   574 AVALLKRTSSSIVLKALEVKEYEPQE---DC----SSPAALDSNH----NMAPPS-DWSPSWVMW 626
            |||.||.|||.:||:.||::  .|.|   ||    .||.||..:.    .:.||: |::|.||.|
Zfish   605 AVANLKNTSSPVVLQVLEMR--PPNESSLDCMPPLHSPCALSPSSPGDVKLPPPNDDYAPLWVSW 667

Human   627 LELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLA 691
            |:|||.||.||||||||:|:|||||.||||.||.|.|:.|||:|||||||||||||||||||||.
Zfish   668 LQLPRHLYCCKDIVLRRSTSGSLGFSIVGGQEELNCNQSFFIRSIVEGTPAYNDGRIRCGDILLE 732

Human   692 VNGRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL 728
            |||:||.||.|..|.||||||:||||||||||||:.|
Zfish   733 VNGKSTWGMTHTALVRLLKELRGRITLTIVSWPGSLL 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LNX1	NP_001119800.1	mRING-HC-C3HC3D_LNX1	38..79	CDD:438435	31/40 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	178..214		15/39 (38%)
		NPXY motif	181..184		2/2 (100%)
		Interaction with MAGEB18. /evidence=ECO:0000269|PubMed:20864041	186..244		31/61 (51%)
		PDZ1_LNX1_2-like	270..358	CDD:467165	64/87 (74%)
		PDZ2_LNX1_2-like	380..462	CDD:467166	56/81 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..494		7/23 (30%)
		PDZ3_LNX1_2-like	506..591	CDD:467167	52/84 (62%)
		PDZ4_LNX1_2-like	637..725	CDD:467168	70/87 (80%)
lnx1	XP_005160562.1	mRING-HC-C3HC3D_LNX1	54..95	CDD:438435	31/40 (78%)
		PDZ1_LNX1_2-like	295..383	CDD:467165	64/87 (74%)
		PDZ2_LNX1_2-like	411..493	CDD:467166	56/81 (69%)
		PDZ3_LNX1_2-like	537..622	CDD:467167	52/84 (62%)
		PDZ4_LNX1_2-like	678..766	CDD:467168	70/87 (80%)