DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LNX1 and CG34375

DIOPT Version :9

Sequence 1:	NP_001119800.1	Gene:	LNX1 / 84708	HGNCID:	6657	Length:	728	Species:	Homo sapiens
Sequence 2:	NP_001163693.1	Gene:	CG34375 / 42715	FlyBaseID:	FBgn0085404	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	444	Identity:	81/444 - (18%)
Similarity:	142/444 - (31%)	Gaps:	149/444 - (33%)

- Green bases have known domain annotations that are detailed below.

Human     5 ESAN-DP--EPLCAVCGQAHSLEENHFYSYP---EEVDDDLICHICLQALLDPLDTPC-GHTYCT 62
            :.|| ||  :|..|.....|.:.:.....:.   :.:...|.|.:||:.:..|....| ||..|.
  Fly    88 QQANIDPNEDPAEASHAVQHGINQQSLQKFATCLQHISQLLECPVCLEVIKPPGWQCCNGHVLCN 152

Human    63 LCLTNFLVEKDFCPMDRKPLVLQ-HCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQT 126
            .|.:..:.    ||:.|.||..: .|    :|.:||...|..:.|
  Fly   153 NCRSRSVK----CPVCRVPLGPRGRC----LLSDKLFTLLAESFP-------------------- 189

Human   127 SCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDG 191
             |.|.      |..|                .|.|......::::..|:|            ...
  Fly   190 -CDGG------KTNK----------------VAASQGHGKLSSVNKCTNE------------YHN 219

Human   192 QP--AISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENT 254
            ||  |::...||               :|:..|:|:|.|..:...:|...:...:.||:| .|..
  Fly   220 QPKMALAKTSSG---------------KSKCGKQISRQLETVLVDQSPREIRRKSQQGQE-QEQA 268

Human   255 TAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLL 319
            ....|.||         .|.||:...:.:                   ::|...:|   .:..|:
  Fly   269 VQEAVLPR---------CTLIKVQHQEAA-------------------VEHFSEEG---HNNMLV 302

Human   320 PGDIIL-----KVNGMD--------ISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPD 371
            ...:.|     ::.|.|        ::.:  |..|::..|..|      ...|:.....:..:..
  Fly   303 KPKLKLSKKSWRITGPDQDGLRCDEVATI--NNGVQVQEQQQQ------QERQQLGHEKSASSES 359

Human   372 AYRPRDDSFHVILNK--SSPEEQLGIKLVRKVDEPGVFIFNVLD--GGVAYRHG 421
            .|:    ::|....|  ||...|||..:..|:....:....|::  ||.:...|
  Fly   360 EYQ----NYHCPTGKSCSSHSYQLGQPVANKLSTVAMQALAVVENSGGASLSAG 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LNX1	NP_001119800.1	mRING-HC-C3HC3D_LNX1	38..79	CDD:319693	12/41 (29%)
		modified RING-HC finger (C3HC3D-type)	41..78	CDD:319693	11/37 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		5/37 (14%)
		NPXY motif	181..184		0/2 (0%)
		Interaction with MAGEB18. /evidence=ECO:0000269\|PubMed:20864041	186..244		11/59 (19%)
		PDZ_signaling	272..355	CDD:238492	13/95 (14%)
		PDZ_signaling	380..460	CDD:238492	12/46 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..494
		PDZ_signaling	505..588	CDD:238492
		PDZ_signaling	637..721	CDD:238492
CG34375	NP_001163693.1	PDZ	13..86	CDD:238080
CG34375	NP_001163693.1	RING	129..168	CDD:238093	12/42 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900