DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LNX1 and loco

DIOPT Version :9

Sequence 1:	NP_001119800.1	Gene:	LNX1 / 84708	HGNCID:	6657	Length:	728	Species:	Homo sapiens
Sequence 2:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster

Alignment Length:	131	Identity:	39/131 - (29%)
Similarity:	58/131 - (44%)	Gaps:	22/131 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   599 EDCSSPAALDSNHNMAP------PSDWSPSWVMWLELPRCLYN---CKDIVLRRNTAGSLGFCIV 654
            || :||||   |...||      ||..:..........|..||   .:.:.:||...| .||.|
  Fly    27 ED-ASPAA---NSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNGIRTVEVRRGYNG-FGFTI- 85

Human   655 GGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLT 719
                  :|.:|..:..|:..:||...| :|.||.|::|||.:.|.:.|..:.:|:....|.|.:.
  Fly    86 ------SGQQPCRLSCIISSSPAEQAG-LRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQ 143

Human   720 I 720
            |
  Fly   144 I 144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LNX1	NP_001119800.1	mRING-HC-C3HC3D_LNX1	38..79	CDD:319693
		modified RING-HC finger (C3HC3D-type)	41..78	CDD:319693
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214
		NPXY motif	181..184
		Interaction with MAGEB18. /evidence=ECO:0000269\|PubMed:20864041	186..244
		PDZ_signaling	272..355	CDD:238492
		PDZ_signaling	380..460	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..494
		PDZ_signaling	505..588	CDD:238492
		PDZ_signaling	637..721	CDD:238492	25/84 (30%)
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	25/85 (29%)
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810