DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LNX1 and Zasp67

DIOPT Version :9

Sequence 1:	NP_001119800.1	Gene:	LNX1 / 84708	HGNCID:	6657	Length:	728	Species:	Homo sapiens
Sequence 2:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	82/403 - (20%)
Similarity:	137/403 - (33%)	Gaps:	119/403 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   272 ITSIKINRVDPSESLSIRLVGGS--ETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN 334
            :..||:.|.| :.....|||||:  :.||..:.:    .:|.||.:..|...|||:::|....:.
  Fly     2 VLDIKMCRFD-NVPWGFRLVGGADYDYPLTVVKV----TEGSIADEAGLRVEDIIVRINDTAATP 61

Human   335 VPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYR-----PRDDSFHVILNKS-----SP 389
            :.|:.|.||:.....|.:..|.||.:         .|||.     |..:.   .|.||     ||
  Fly    62 LTHDEAHRLIMGSGSVFYFGVYRENE---------EDAYECLKKFPTSEG---SLTKSPMPTISP 114

Human   390 E-----EQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSP---ESAA 446
            .     .||......:..||..|:                                 |   |.||
  Fly   115 SPTPSLSQLTETTNARTPEPEPFV---------------------------------PLPRELAA 146

Human   447 HLIQASERRVHLVVSRQVRQRSPDIF-QEAGWNSNGSWSPGPGERSNTP--------KPLHPTIT 502
            ..:.|....|.:.|..:.||...::. :|...:.||..:||..:....|        .|..|...
  Fly   147 ATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGLPVENLYLPDLPDRPCSA 211

Human   503 CHE----KVVNIQKDPGESLGMTVAGGA----SHREWDLPIYVISVEPGGVISRDGRIKTGDILL 559
            ..|    |:|.      |.:...::|.:    .|....:..|.|..:||..:|       .|:|.
  Fly   212 LSERQEIKLVE------EEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCMS-------SDVLR 263

Human   560 NVD------GVELTEVSRSEAVAL------LKRTSSSIVLKALEVKEYE-------PQEDCSSPA 605
            :::      .:|..:.:|..:..|      :.::..|:..:......|:       |:|....|.
  Fly   264 SLNEEVTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPMPE 328

Human   606 ALDSNHNMAPPSD 618
            |..:.....||.:
  Fly   329 AKPAPKEATPPKE 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LNX1	NP_001119800.1	mRING-HC-C3HC3D_LNX1	38..79	CDD:319693
		modified RING-HC finger (C3HC3D-type)	41..78	CDD:319693
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214
		NPXY motif	181..184
		Interaction with MAGEB18. /evidence=ECO:0000269\|PubMed:20864041	186..244
		PDZ_signaling	272..355	CDD:238492	24/84 (29%)
		PDZ_signaling	380..460	CDD:238492	16/92 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..494		4/18 (22%)
		PDZ_signaling	505..588	CDD:238492	17/102 (17%)
		PDZ_signaling	637..721	CDD:238492
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	23/77 (30%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900