DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LNX1 and CG9014

DIOPT Version :9

Sequence 1:NP_001119800.1 Gene:LNX1 / 84708 HGNCID:6657 Length:728 Species:Homo sapiens
Sequence 2:NP_001285905.1 Gene:CG9014 / 34777 FlyBaseID:FBgn0028847 Length:328 Species:Drosophila melanogaster


Alignment Length:332 Identity:74/332 - (22%)
Similarity:133/332 - (40%) Gaps:68/332 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    35 VDDDLICHICLQALLDPL-DTPCGHTYCTLCLTNFLVEKDFCPMDRKPLVLQHCKKSSILVNKLL 98
            ||::|||.||...|.:|: .:.|.|.:|..|:..::::|..||:||..|:..|....|.|:..:|
  Fly    12 VDEELICPICTDVLEEPVQSSECEHAFCRACIDKWMIQKQICPVDRSGLLTSHLVPVSRLMRNML 76

Human    99 NKLLVTCPFREH-CTQVLQRCDLEHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSP 162
            ::|.:.|.|.:. |.|:|.   || .|:|......|       ..:....|..||.   ...|..
  Fly    77 SRLKIKCTFSQSGCAQMLA---LE-EFRTHVAACEH-------NPKVVVECSKGCG---MKVPKD 127

Human   163 EVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRA 227
            |:|....:..:.:           ..|.....:|.:...:|:..     |:|:.:.|..:.....
  Fly   128 EMSRHNCVFELRE-----------LVEKLAKEVSDLKQKQSDME-----EQSSSQRREMELFQYY 176

Human   228 LSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITS--IKINRVDPSESLSIRL 290
            ::.||.|  ...:.|..:|....|        ..:..|.:|...|.:  ..|:..|....|.:|.
  Fly   177 IAALRST--NPMLRNIGEQLDRFS--------LMQWGHGLPLANIHTWGSLISTPDNPMHLMVRD 231

Human   291 V---GGSETPLVHIIIQHIYRD----GVIARDG-------------RLLPGDIILK----VNGMD 331
            |   .|....:::::::..:.|    |::..|.             ||:||.:|.|    |.|.:
  Fly   232 VLRESGCPMHMLNMLVERCHEDRWPEGLMTLDDRRENQHLMSRYVTRLVPGLVIGKPCVVVLGGE 296

Human   332 ISNVPHN 338
            .:::|.|
  Fly   297 NTHMPEN 303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LNX1NP_001119800.1 mRING-HC-C3HC3D_LNX1 38..79 CDD:319693 14/41 (34%)
modified RING-HC finger (C3HC3D-type) 41..78 CDD:319693 12/37 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 178..214 4/35 (11%)
NPXY motif 181..184 0/2 (0%)
Interaction with MAGEB18. /evidence=ECO:0000269|PubMed:20864041 186..244 10/57 (18%)
PDZ_signaling 272..355 CDD:238492 20/93 (22%)
PDZ_signaling 380..460 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..494
PDZ_signaling 505..588 CDD:238492
PDZ_signaling 637..721 CDD:238492
CG9014NP_001285905.1 zf-C3HC4 18..55 CDD:278524 11/36 (31%)
USP8_interact 137..319 CDD:286082 34/193 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0297
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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