DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LNX1 and Dlg5

DIOPT Version :9

Sequence 1:	NP_001119800.1	Gene:	LNX1 / 84708	HGNCID:	6657	Length:	728	Species:	Homo sapiens
Sequence 2:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	120/619 - (19%)
Similarity:	202/619 - (32%)	Gaps:	222/619 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   130 GASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPA 194
            ||.:.|.|..||:.:|          ....||....|:.:.|::.:..|..:..||:|.
  Fly  1151 GAIYEGGTFPRKKDNQ----------RLRIPSNPSVASKSSSMVKNSSGSIDHHYVTST------ 1199

Human   195 ISPVDSGRSNRTRARPFERSTIRSRSFKKINRA-LSVLRRTKSGSAVANHADQGRENSENTTAPE 258
             .||..|                |.|....:|| :|::..:...|..||
  Fly  1200 -GPVSGG----------------SMSASSSDRAPMSLMSSSIHNSYGAN---------------- 1231

Human   259 VFPRLYHLIPDGEITSIKINRVDPSESLSIRLVG---------GSETPLVHIIIQHIYRDGVIAR 314
                    |..|..|...|.            ||         ||..|.||:        .|::.
  Fly  1232 --------IAGGNGTGSSIG------------VGGGGGGGSGRGSPMPQVHV--------EVLSH 1268

Human   315 DGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDS 379
            .|    |.     :|...||||.::..     |..:..:|:.:..|
  Fly  1269 GG----GG-----SGKRNSNVPADFLC-----PGDLRRVTIDKRDK------------------- 1300

Human   380 FHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPES 444
                        .|||.:....:..|:|:..|.|...|.|.| |:..|::|.:.|.::|..:.|.
  Fly  1301 ------------SLGITIQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEI 1352

Human   445 AAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWN------SNGSWSPGPGERSNTPKPLHPTITC 503
            ||::::.......::|... .::.|.|..|...|      .|.|.||.|   .|:|:|
  Fly  1353 AANVLRQCGDSFTMLVQYN-PEKFPSIEYEGAHNLEPESPINHSGSPTP---RNSPRP------- 1406

Human   504 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDG--------RIKT---GDI 557
                      |..:                .::.:.::|....:|.|        .||.   .|.
  Fly  1407 ----------PARN----------------SLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDS 1445

Human   558 LLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPS 622
            |.|...:..::...|.|......|:|:    ...|.:.||:.....|.|       :.|::
  Fly  1446 LENQSDISSSQDMPSSAATTTTTTASA----TSTVYDEEPKPSLPPPPA-------SVPAE---- 1495

Human   623 WVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNK-PFFIKSIVEGTPAYNDGRIRCG 686
                        ..:.:.|..:.:.:||..:.|      ||| ..::..:..|:|:.:.| ||.|
  Fly  1496 ------------TLRYVTLHMDKSKNLGIKLFG------GNKVGIYVHDVAVGSPSDHAG-IRKG 1541

Human   687 DILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
            |.:|..||...||:.....|..:.:|...:|:.:
  Fly  1542 DQILEYNGVDLSGVTAEQAANEISKLTDTVTMLV 1575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LNX1	NP_001119800.1	mRING-HC-C3HC3D_LNX1	38..79	CDD:319693
		modified RING-HC finger (C3HC3D-type)	41..78	CDD:319693
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		7/35 (20%)
		NPXY motif	181..184		0/2 (0%)
		Interaction with MAGEB18. /evidence=ECO:0000269\|PubMed:20864041	186..244		12/58 (21%)
		PDZ_signaling	272..355	CDD:238492	18/91 (20%)
		PDZ_signaling	380..460	CDD:238492	18/79 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..494		7/24 (29%)
		PDZ_signaling	505..588	CDD:238492	13/93 (14%)
		PDZ_signaling	637..721	CDD:238492	22/85 (26%)
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	20/110 (18%)
		PDZ_signaling	1497..1576	CDD:238492	22/86 (26%)
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810