DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LNX1 and Traf-like

DIOPT Version :9

Sequence 1:	NP_001119800.1	Gene:	LNX1 / 84708	HGNCID:	6657	Length:	728	Species:	Homo sapiens
Sequence 2:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster

Alignment Length:	194	Identity:	39/194 - (20%)
Similarity:	69/194 - (35%)	Gaps:	68/194 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   261 PRLYHLIPDGEITSIKINRVDPSESLSIRL----VGGSETPLVHIIIQHIYRDGVIARDGRLLPG 321
            ||..|.:.:.:..|:.::|:|......:.:    ||...:.|...|.|.::
  Fly    88 PRNQHNLSNQQRMSVSMDRLDRQSDQRLLVIEQDVGTIRSVLNEEIRQRLH-------------- 138

Human   322 DIILKVNGMDISNVPHNYAVRLLRQPCQVL--WLTVMREQKFRSRNNGQAPDAYRPRDD------ 378
             :|     .|:.|:         |:..||:  |          :|...:|.|..|.:.:
  Fly   139 -LI-----TDVGNI---------RKQNQVVEDW----------TRETEKAMDDLRRQMEEETNRK 178

Human   379 SFHVILNK----------SSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAI 432
            :|.:..|:          .|.:||:..:|    ||....: |.|...|.|...||  ||.:|.:
  Fly   179 AFAIEQNQLDVQYCCDITQSLKEQVESRL----DEAQKLV-NQLSADVTYHQNQL--NDNILKL 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LNX1	NP_001119800.1	mRING-HC-C3HC3D_LNX1	38..79	CDD:319693
		modified RING-HC finger (C3HC3D-type)	41..78	CDD:319693
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214
		NPXY motif	181..184
		Interaction with MAGEB18. /evidence=ECO:0000269\|PubMed:20864041	186..244
		PDZ_signaling	272..355	CDD:238492	15/88 (17%)
		PDZ_signaling	380..460	CDD:238492	17/63 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..494
		PDZ_signaling	505..588	CDD:238492
		PDZ_signaling	637..721	CDD:238492
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	39/194 (20%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900