DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LNX1 and Traf6

DIOPT Version :9

Sequence 1:NP_001119800.1 Gene:LNX1 / 84708 HGNCID:6657 Length:728 Species:Homo sapiens
Sequence 2:NP_511080.2 Gene:Traf6 / 31746 FlyBaseID:FBgn0265464 Length:475 Species:Drosophila melanogaster


Alignment Length:420 Identity:89/420 - (21%)
Similarity:146/420 - (34%) Gaps:135/420 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    22 SLEENHFYS----YPEEVDDDLI-----CHICLQALLDPLDTPCGHTYCTLCLTNFLVEKD-FCP 76
            :|.:||.|:    ...|.:::|:     |.||:..|.:|:.|.|||.:|..|||.::.:.: .||
  Fly    76 ALNQNHHYAPGSDTSGEQEEELLDSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCP 140

Human    77 MDRKPLVLQH------------------CKKSSILVNKL-----LNKLLVTCPFR-------EHC 111
            ||.|.|..:|                  |..||:..:.:     |::.|.:||:|       |.|
  Fly   141 MDNKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHLPSCPYRRQQEPQEEKC 205

Human   112 TQVLQRCD---------LEHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAA 167
            .....:||         ||.|.:...  ..|..|.....:::        |..|.....|..|.|
  Fly   206 PFAKIKCDFVGRPETNQLEEHLKADM--PHHMQLMLQAFQQT--------AIATWQPHKPSTSGA 260

Human   168 ATISLMTDEPGLDNPAYVSSAEDG------QPAISPVDSGRSNRTRARPFERSTIRSRSFKKINR 226
            |..:....:.....|.|.:..::.      |..:......|...||....::....:|....::.
  Fly   261 AVENGHGQQQLPPPPQYANGVDEQIVQTMYQRIVVLEQRTREQETRLENMQKQLRLARQQAPVDP 325

Human   227 ALS----VLRRTKSGSAVANHADQGRENSENT-------TAP---------EVFPRLYHLIP--- 268
            ..|    |.|..:.|:.||    :.|.|:.|.       |:|         .:.||..|::.   
  Fly   326 RYSNGTIVWRIEQLGALVA----RLRANANNQVYSHECYTSPHGYKFCARLNIQPRKPHVLSLHV 386

Human   269 ---------------DGEITSIKINRVD--------------------PSESLSIRLVGGSETPL 298
                           .|.|....::..|                    |.|::|.|..|..|   
  Fly   387 HLMQSENDYHLDWPFKGRIKLCMVHPADATLSQHDTIMTKPEILAFHKPREAISTRGFGFLE--- 448

Human   299 VHIIIQHIYRDGVIARDGRLLPGDIILKVN 328
             :..|.:|.:.|..| |.|||   |.:::|
  Fly   449 -YANISNIIQLGFCA-DDRLL---IKIEIN 473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LNX1NP_001119800.1 mRING-HC-C3HC3D_LNX1 38..79 CDD:319693 17/46 (37%)
modified RING-HC finger (C3HC3D-type) 41..78 CDD:319693 15/37 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 178..214 6/41 (15%)
NPXY motif 181..184 1/2 (50%)
Interaction with MAGEB18. /evidence=ECO:0000269|PubMed:20864041 186..244 11/67 (16%)
PDZ_signaling 272..355 CDD:238492 18/77 (23%)
PDZ_signaling 380..460 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..494
PDZ_signaling 505..588 CDD:238492
PDZ_signaling 637..721 CDD:238492
Traf6NP_511080.2 RING 103..141 CDD:238093 14/37 (38%)
Sina 163..>230 CDD:302762 15/66 (23%)
MATH_TRAF6 330..473 CDD:239745 31/154 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0297
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.