DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LNX1 and PsGEF

DIOPT Version :9

Sequence 1:NP_001119800.1 Gene:LNX1 / 84708 HGNCID:6657 Length:728 Species:Homo sapiens
Sequence 2:NP_996333.4 Gene:PsGEF / 31224 FlyBaseID:FBgn0264598 Length:2777 Species:Drosophila melanogaster


Alignment Length:736 Identity:145/736 - (19%)
Similarity:237/736 - (32%) Gaps:210/736 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     6 SANDPEPLCAVCGQAHSLEENH---FYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTN 67
            |.::.|.:.:|..|:||...:.   ..|.|..:|...:|..|             |..|      
  Fly  1386 STSEAEGVTSVISQSHSTTSDSQITVRSSPIVLDKLAVCRHC-------------HKNC------ 1431

Human    68 FLVEKDFCPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQTSCK--- 129
                :...|...:|........||.....|.|.|.|     :|......||         ||   
  Fly  1432 ----QQSGPGGARPGGGGGVNNSSSTPVLLCNSLKV-----QHSQSSPNRC---------CKLSN 1478

Human   130 ---GASHYGLTKDRKRRSQDGCPDGCASLTATAPSP---EVSAAATIS---------------LM 173
               ||:.....|:..|..     .|..|:|:.:.|.   |:|:....|               |:
  Fly  1479 GIAGATEMANPKNSNRTG-----TGTGSVTSMSSSTITGELSSKVVASSSRRETGDTESDVAQLI 1538

Human   174 TDE----------------PG-------------------LDNPAYVSSAEDGQPAI-------S 196
            |||                |.                   ||.|..|||..:|..:.       .
  Fly  1539 TDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSLPNGHCSAGVGGGSPK 1603

Human   197 PVDSGRSNRTRAR-----PFERSTIRSRSFKKINRALSVLRR--TK---SGSAVANHADQG---- 247
            |:...|..|..|:     |..::..:.::...|.....::|.  ||   ||||....:..|    
  Fly  1604 PLPPPRRTRVVAQMCQEPPRPKANQQVKAIVTITETARIMRSSPTKGSGSGSATGTGSVGGSPAK 1668

Human   248 ------RENSENTTAPEVFP-RLYH----LIPDGEITSIKINRVDPSESLSIRLVG--------- 292
                  |...|:.|..::.| ::.|    |:...:.|:..:.:....|.||:.|:|         
  Fly  1669 YAACHCRCTPEDFTHAQLSPDKMEHQTCKLLESPKQTTTTLEQKQEDEQLSLMLIGLAQLAPAAT 1733

Human   293 --GSE--------TPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQP 347
              |.|        ||.:.::..  ..|.|:.:....:..:.....||...|..  :.|....:||
  Fly  1734 LCGQERIPKEENSTPTIAVVPP--TPDSVLTKTSTHVWDNSGCSSNGGGTSTT--STATTTTKQP 1794

Human   348 CQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDE----PGVFI 408
            .|.:...:..:....|..:.:.|  |||...:.......||.|:......:.:.||    ...|.
  Fly  1795 RQAIIENIPEDSCDESPLDEEPP--YRPMSSALRRFGTMSSLEKLPSDDRMDEADELDDDLDSFK 1857

Human   409 FNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ-------ASERRVHLVVSRQVRQ 466
            .|..||.........|:.|...|:..:||  |:..|:..::.       |...|....||.::  
  Fly  1858 PNGHDGNSPQNEEDDEDADSERALVQNDL--GASSSSGVIVNGEGLASGAWTNRAGAYVSDKM-- 1918

Human   467 RSPDIFQEAGWNSN---GSWSPGPGERSNTPKPLHPTITCHEKVVNIQKD-------PGESLGMT 521
               ..|:|:....:   |.|:.|..::.      |...|..|  .:.|.|       .||.:..|
  Fly  1919 ---SFFEESRAFIDKYLGRWNAGDAQQQ------HQQGTASE--TDEQMDECTSGATSGEEVWGT 1972

Human   522 VAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSI- 585
            ...|..:.:.||.:    :......|...:..|.   ||.|  :.||:...|.:.....|:|:| 
  Fly  1973 PTSGGDNDDQDLQL----INSENTHSSPTKSSTS---LNDD--DDTELMMDELLMAPPMTASTIR 2028

Human   586 -VLKALEVKEYEP--QEDCSS 603
             :|.....:..||  :|:..|
  Fly  2029 GLLPRFYRRRLEPLFEEETES 2049

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LNX1NP_001119800.1 mRING-HC-C3HC3D_LNX1 38..79 CDD:319693 5/40 (13%)
modified RING-HC finger (C3HC3D-type) 41..78 CDD:319693 5/36 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 178..214 12/66 (18%)
NPXY motif 181..184 1/2 (50%)
Interaction with MAGEB18. /evidence=ECO:0000269|PubMed:20864041 186..244 16/74 (22%)
PDZ_signaling 272..355 CDD:238492 19/101 (19%)
PDZ_signaling 380..460 CDD:238492 18/90 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..494 3/21 (14%)
PDZ_signaling 505..588 CDD:238492 20/91 (22%)
PDZ_signaling 637..721 CDD:238492
PsGEFNP_996333.4 DUF4799 <102..209 CDD:292674
C2 286..>381 CDD:278593
PDZ_signaling 644..716 CDD:238492
RhoGEF 831..1000 CDD:295373
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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