DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LNX1 and sprt

DIOPT Version :9

Sequence 1:NP_001119800.1 Gene:LNX1 / 84708 HGNCID:6657 Length:728 Species:Homo sapiens
Sequence 2:NP_610683.1 Gene:sprt / 246397 FlyBaseID:FBgn0082585 Length:634 Species:Drosophila melanogaster


Alignment Length:444 Identity:85/444 - (19%)
Similarity:149/444 - (33%) Gaps:138/444 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   131 ASHYGLTKDRKRRSQDGCPDGCA-----SLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSAED 190
            |.|....|.:........|.||.     ||.:||.:.:.:|:.|.:        ......:....
  Fly    13 AHHRAFAKQKSASMTILNPKGCGSAVKYSLHSTAETNQETASTTTT--------STHCSTTGRRR 69

Human   191 GQPAISPVDSGRSNRTRARPFERSTIRSRSF----KKINRALSVLRRTKSGSAVANHADQGRENS 251
            ...::....|.||.|:.::.. ||.::.|..    .:|...|..|.| .:|..:        :.|
  Fly    70 KGGSLGGTLSSRSTRSESKEL-RSALQDREAVIQNLRIQLCLGKLPR-PTGPPL--------DES 124

Human   252 ENTTAPEVFPRLYHLIPDGEITSIKI-------NRVDPSESLSIRLVGGSETPLVHIIIQHIYRD 309
            |...|.:   :|..|..:.|...|||       .::|.::::.||:                   
  Fly   125 EKPAAEQ---KLNRLKTEAENKRIKIKNLKSALEKLDITDNIDIRI------------------- 167

Human   310 GVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYR 374
                |...|                   .||  |.|:..|:  |:::.|.:           |.:
  Fly   168 ----RQAEL-------------------EYA--LGREELQM--LSIVEEAR-----------ALQ 194

Human   375 PRDDSFHVILNKSSPEEQL-------GIKL--------------VRKVDEPGVFIFNVLDGGVAY 418
            .|       |.||.||.|.       |:.|              .::.|:||.::...|:|...|
  Fly   195 AR-------LEKSKPEAQTLYNIISSGVSLSLHAVHATSGRWAVQQRTDQPGFYVEWALEGDGLY 252

Human   419 RHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQ----VRQRSPDIFQEAGWNS 479
            :      .||:|.|||..:...|.|.....: .:..:..:||.|:    :.|:..|..:|.....
  Fly   253 K------GDRILEINGRLVTGKSKEELQKQV-GNSGKCQMVVLRKKSVPIPQKQLDQEKENNMRL 310

Human   480 NG--SWSPGPGERSNTPKPLHPT---ITCHEKVVNIQKDPGESLGMTVAGGASH 528
            ..  |:.........|.|..||:   ....::..|.|::|.::...|.:..:.|
  Fly   311 QHRISYLEEQVRELQTVKEHHPSQQQQQQQQQQQNPQQNPQQNPQQTSSNQSQH 364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LNX1NP_001119800.1 mRING-HC-C3HC3D_LNX1 38..79 CDD:319693
modified RING-HC finger (C3HC3D-type) 41..78 CDD:319693
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 178..214 4/35 (11%)
NPXY motif 181..184 0/2 (0%)
Interaction with MAGEB18. /evidence=ECO:0000269|PubMed:20864041 186..244 12/61 (20%)
PDZ_signaling 272..355 CDD:238492 14/89 (16%)
PDZ_signaling 380..460 CDD:238492 22/100 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..494 1/20 (5%)
PDZ_signaling 505..588 CDD:238492 5/24 (21%)
PDZ_signaling 637..721 CDD:238492
sprtNP_610683.1 PDZ <247..288 CDD:294084 11/47 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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