Protein Alignment LNX1 and frm-5.1

DIOPT Version :10

• Sequence 1: NP_001119800.1
• Gene: LNX1 / 84708
• HGNCID: 6657
• Length: 728
• Species: Homo sapiens
• Sequence 2: NP_001408266.1
• Gene: frm-5.1 / 176822
• WormBaseID: WBGene00001492
• Length: 1567
• Species: Caenorhabditis elegans
• Alignment Length: 745
• Identity: 143/745 - (19%)
• Similarity: 254/745 - (34%)
• Gaps: 255/745 - (34%)

Human    84 LQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQTS----CKGASHYGLTKDRKRRS 144
            ||..||..::|           ....|..|:......:||.::|    ...:.|..:.|.|:.:|
 Worm   964 LQFDKKRFVIV-----------AVGAHDEQIESTFYTDHHSKSSYFVRFAASQHRWMMKMRQWKS 1017

Human   145 Q-------DGCPDGCASLTATAPSP-----EVSAAAT------------ISLMTDEPGLDNPAYV 185
            .       ...||.........|:|     |.|..:|            :|:..::|..:.|
 Worm  1018 TLRHENTIQAMPDVIVEGQTIPPAPIRQGLEESPPSTPLLASADQIFAKMSVSQEKPAANRP--- 1079

Human   186 SSAEDGQPAIS--------PVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVAN 242
              ||...||.|        .||.|....::|..|||                           .:
 Worm  1080 --AELPPPAPSSKFAAQYDTVDEGIVCDSQAENFER---------------------------VD 1115

Human   243 HADQGRENSENTTAPEVFPRLYHLIPDG---EITSIKINRVDPSESLSIRLVGGSETPLVHIIIQ 304
            ..|.|     |.|            |.|   :|..:|    ||:..|.:.||.|:...:..:.::
 Worm  1116 STDNG-----NVT------------PRGMQFDILLVK----DPANGLGLTLVDGNLNGVPGVYVK 1159

Human   305 HIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTV------MREQK--- 360
            .:..:|...:.| :..||.|::|....:......:||.|:|:..|.:.:.:      :|.||
 Worm  1160 LVADNGAGMKAG-VCVGDRIVQVGTESMEGHDRLHAVELVRRCGQRVPMVIARLDGLIRHQKDVS 1223

Human   361 ------------FRS----------RNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDE 403
                        |.|          |.|||:.....||         |::...|      |.|.:
 Worm  1224 AEMLASAGRKKSFTSSSGDLLNAPNRTNGQSRTPPAPR---------KAANRRQ------RAVSD 1273

Human   404 PGVF--IFNVLDG-------GVAYRHGQLEENDRVLAINGHDLRYGSPESAAHL------IQAS- 452
            .|..  ....|||       .::..|  |:|:|....      .|..|.::.:.      :|||
 Worm  1274 FGAIGDALPTLDGDNLINIKAISGLH--LDESDEEKG------EYRLPTTSMYAFDRDDDLQASI 1330

Human   453 --------------------ERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPL 497
                                .||.:|.::.::.:.:.:...:.|....|
 Worm  1331 KESKKPAPEPKSGELRKYRYARRSNLEIAEEIEEEAVESSDDDGQIDEG---------------- 1379

Human   498 HPTITCHEKVVNIQKDPGE--SLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLN 560
                   ::|::::.|..|  |||:.:|..:..    :.|..::.||  .||... |:.||:||.
 Worm  1380 -------KRVIDVELDRNENGSLGVQIASLSGR----VCIKQLTSEP--AISHPD-IRVGDVLLY 1430

Human   561 VDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVM 625
            |:|:.:......|.||:|:.....:||....           .|.|....|:.:..|..:|
 Worm  1431 VNGIAVEGKVHQEVVAMLRGGGDRVVLGVQR-----------PPPAYSDQHHASSTSASAP---- 1480

Human   626 WLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILL 690
                      ...::|.:....:||..:.    :...:...||::|.:.:.|.::|.:|.||.|:
 Worm  1481 ----------LISVMLLKKPMATLGLSLA----KRTMSDGIFIRNIAQDSAASSEGTLRVGDRLV 1531

Human   691 AVNGRSTSGMIHACLARLLKELKGRITLTI 720
            :::|....|...|.:...||.::|.:.:|:
 Worm  1532 SLDGEPVDGFTPATILEKLKLVQGPVQITV 1561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LNX1	NP_001119800.1	mRING-HC-C3HC3D_LNX1	38..79	CDD:438435
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	178..214		12/43 (28%)
		NPXY motif	181..184		1/2 (50%)
		Interaction with MAGEB18. /evidence=ECO:0000269|PubMed:20864041	186..244		12/65 (18%)
		PDZ1_LNX1_2-like	270..358	CDD:467165	20/96 (21%)
		PDZ2_LNX1_2-like	380..462	CDD:467166	20/117 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..494		2/18 (11%)
		PDZ3_LNX1_2-like	506..591	CDD:467167	25/86 (29%)
		PDZ4_LNX1_2-like	637..725	CDD:467168	19/84 (23%)
frm-5.1	NP_001408266.1	Protein Kinases, catalytic domain	9..164	CDD:473864
		B41	688..893	CDD:214604
		PH-like	889..1018	CDD:473070	13/64 (20%)
		PDZ_canonical	1130..1210	CDD:467153	19/84 (23%)
		PDZ	1381..1463	CDD:214570	25/99 (25%)
		PDZ_canonical	1486..1562	CDD:467153	19/80 (24%)