DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LNX1 and Lnx1

DIOPT Version :9

Sequence 1:	NP_001119800.1	Gene:	LNX1 / 84708	HGNCID:	6657	Length:	728	Species:	Homo sapiens
Sequence 2:	NP_001153049.1	Gene:	Lnx1 / 16924	MGIID:	1278335	Length:	728	Species:	Mus musculus

Alignment Length:	732	Identity:	644/732 - (87%)
Similarity:	677/732 - (92%)	Gaps:	8/732 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNQPESAND----PEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYC 61
            ||||:.|:|    |||||.||||.||.||||||:|.|:|||||||||||||||||||||||||||
Mouse     1 MNQPDLADDPDPSPEPLCIVCGQNHSPEENHFYTYTEDVDDDLICHICLQALLDPLDTPCGHTYC 65

Human    62 TLCLTNFLVEKDFCPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQT 126
            |||||||||||||||:||||:|||||||||||||||||||||||||.||||:|||||||:|||||
Mouse    66 TLCLTNFLVEKDFCPVDRKPVVLQHCKKSSILVNKLLNKLLVTCPFTEHCTEVLQRCDLQHHFQT 130

Human   127 SCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDG 191
            |||||||||||||||||||||||||||||.||..|||||||||||||||||||||||||||.|||
Mouse   131 SCKGASHYGLTKDRKRRSQDGCPDGCASLMATTLSPEVSAAATISLMTDEPGLDNPAYVSSVEDG 195

Human   192 QPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTA 256
            :|..:..|||||||||||||||||:|||||||||||||.||||||||.||||.||||:||||||.
Mouse   196 EPVANSSDSGRSNRTRARPFERSTMRSRSFKKINRALSALRRTKSGSVVANHVDQGRDNSENTTV 260

Human   257 PEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPG 321
            |||||||:|||||||||||||||.|||||||||||||||||||||||||||||||||||||||||
Mouse   261 PEVFPRLFHLIPDGEITSIKINRADPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPG 325

Human   322 DIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNK 386
            ||||||||||||||||||||||||||||||.|||:||||||||:|...||:|.||||||||||||
Mouse   326 DIILKVNGMDISNVPHNYAVRLLRQPCQVLRLTVLREQKFRSRSNAHVPDSYGPRDDSFHVILNK 390

Human   387 SSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQA 451
            |||||||||||||:||||||||||||:||||.||||||||||||||||||||:||||||||||||
Mouse   391 SSPEEQLGIKLVRRVDEPGVFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFGSPESAAHLIQA 455

Human   452 SERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGE 516
            |||||||||||||||.||||||||||.|||..|||||||:...|   |..|||||||::.|||.|
Mouse   456 SERRVHLVVSRQVRQSSPDIFQEAGWISNGQQSPGPGERNTASK---PAATCHEKVVSVWKDPSE 517

Human   517 SLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRT 581
            ||||||.||||||||||||||||||||||||||||||||||||||:|:|||||||:||||:||..
Mouse   518 SLGMTVGGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILKSA 582

Human   582 SSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTA 646
            .||:|||||||||.|.|||| ||||||||||:.||.|||||||||||||:.|.||||::||||||
Mouse   583 PSSVVLKALEVKEQEAQEDC-SPAALDSNHNVTPPGDWSPSWVMWLELPQYLCNCKDVILRRNTA 646

Human   647 GSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKE 711
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||:|||
Mouse   647 GSLGFCIVGGYEEYSGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARMLKE 711

Human   712 LKGRITLTIVSWPGTFL 728
            |||||||||.|||||||
Mouse   712 LKGRITLTIASWPGTFL 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LNX1	NP_001119800.1	mRING-HC-C3HC3D_LNX1	38..79	CDD:319693	39/40 (98%)
		modified RING-HC finger (C3HC3D-type)	41..78	CDD:319693	36/36 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		28/35 (80%)
		NPXY motif	181..184		2/2 (100%)
		Interaction with MAGEB18. /evidence=ECO:0000269\|PubMed:20864041	186..244		47/57 (82%)
		PDZ_signaling	272..355	CDD:238492	80/82 (98%)
		PDZ_signaling	380..460	CDD:238492	75/79 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..494		13/18 (72%)
		PDZ_signaling	505..588	CDD:238492	69/82 (84%)
		PDZ_signaling	637..721	CDD:238492	79/83 (95%)
Lnx1	NP_001153049.1	mRING-HC-C3HC3D_LNX1	42..83	CDD:319693	39/40 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..220		27/34 (79%)
		NPXY motif	185..188		2/2 (100%)
		Interaction with MAGEB18. /evidence=ECO:0000250	186..244		48/57 (84%)
		PDZ_signaling	276..360	CDD:238492	81/83 (98%)
		PDZ_signaling	384..464	CDD:238492	75/79 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..500		12/21 (57%)
		PDZ_signaling	506..589	CDD:238492	69/82 (84%)
		PDZ_signaling	637..721	CDD:238492	79/83 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83964422
Domainoid	1	1.000	355	1.000	Domainoid score	I13221
eggNOG	1	0.900	-	-		E1_KOG0297
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7819
Inparanoid	1	1.050	1312	1.000	Inparanoid score	I3782
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43472
OrthoDB	1	1.010	-	-		D277034at33208
OrthoFinder	1	1.000	-	-		FOG0011653
OrthoInspector	1	1.000	-	-		oto116294
orthoMCL	1	0.900	-	-		OOG6_106227
Panther	1	1.100	-	-	LDO	PTHR19964
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11904
SonicParanoid	1	1.000	-	-		X2365
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300