Protein Alignment GPT2 and Tat

DIOPT Version :10

• Sequence 1: XP_047290768.1
• Gene: GPT2 / 84706
• HGNCID: 18062
• Length: 554
• Species: Homo sapiens
• Sequence 2: NP_572953.1
• Gene: Tat / 32381
• FlyBaseID: FBgn0030558
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 580
• Identity: 124/580 - (21%)
• Similarity: 220/580 - (37%)
• Gaps: 145/580 - (25%)

Human     9 RRGCGPRTPSSWGRSQSSAAA--------EASAVLKVRPERSRRERIL--TLESMNPQVKAVEYA 63
            |..|..|:||   ..:|.|..        :|.|.|:::.:..|:::.|  |..:.:...|...:.
  Fly    19 RASCTSRSPS---EPESPAPVTPNCDVVDQALAELQLQSQDIRKQQDLVDTTATSSSSRKRSGWE 80

Human    64 VRGPIVLKAGEIELELQRGIK--------KPFTE--VIRANIGDAQAMGQQPITFLRQVMALCTY 118
            ::|      .::.|.....|:        ||..|  :|..:|||       |.||
  Fly    81 IKG------SKLSLNTHNRIRNIVESLKIKPNPEKPMIPLSIGD-------PTTF---------- 122

Human   119 PNLLDSPSFPEDAKKRARRILQACGGNSLGEAPTCQAPRREMNECSQAAPASSGGSCMRMGSYSA 183
                                     ||......|.:|....:         .||    :...|::
  Fly   123 -------------------------GNLKAADETMKAVLHSL---------ESG----KYNGYAS 149

Human   184 SQGVNCIREDVAAYIT--RRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQ 246
            :||....|:.||.|..  |.||.:  |.:.:.|.:|.|..:...:..|...|    ..|::|.|.
  Fly   150 TQGHEIARKAVAKYSAHQRPDGEI--DANEVVLCSGCSSALEYCILALADRG----QNVLVPRPG 208

Human   247 YPLYSAVISELDAIQVNYY-LDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSR 310
            :.||..:...|| |:|.|| |..:..|..::.:|...:.|     :...|.|.||.||.|.|...
  Fly   209 FCLYYTLAQGLD-IEVRYYDLLPDQQWRADLVQLESLIDE-----NTAALLINNPSNPCGSVFDE 267

Human   311 KCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYM 375
            |.:.::|.......|.::|||:|:..|: |..:..:...:        ::.|.:.|....:|.::
  Fly   268 KHLRELIAICERHYLPIIADEIYEHFVF-PGSKHLAVSSL--------TTEVPVLSCGGLTKRFL 323

Human   376 GECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSG-----QAAM-DIVVNPPVAGEESFEQFS 434
            .. |:|.|::.|.:....::..:|.|.:  :|..:.|     |.|: ||:...|    :|:
  Fly   324 VP-GWRMGWIIVHDRKNRLRDAIVGLKN--MCGRILGSNTIIQGALPDILTKTP----QSY---- 377

Human   435 REKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCM 499
              .:.|:..|...|.|...:..||.|:......||||..       ..|...:..:...|..:..
  Fly   378 --FDGVIDVLHSNAMLAYKMLKQVRGLDPVMPNGAMYMM-------IGVSIERFPEFKDDTHFVQ 433

Human   500 KLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDF---HI-----NFLE 551
            :::.|..:..:|||.|   |...:.|:.:..|...::....::.:|   |.     ||:|
  Fly   434 EMVNEQSVFCLPGSCF---EYPGYVRIVLTVPGAMIEEACSRIAEFCDRHYKKESRNFIE 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPT2	XP_047290768.1	PTZ00377	48..554	CDD:240391	113/533 (21%)
Tat	NP_572953.1	tyr_amTase_E	79..481	CDD:273529	106/506 (21%)