DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYO18B and MYO1

DIOPT Version :10

Sequence 1:XP_011528760.1 Gene:MYO18B / 84700 HGNCID:18150 Length:2610 Species:Homo sapiens
Sequence 2:NP_011888.1 Gene:MYO1 / 856418 SGDID:S000001065 Length:1928 Species:Saccharomyces cerevisiae


Alignment Length:1959 Identity:446/1959 - (22%)
Similarity:819/1959 - (41%) Gaps:459/1959 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   538 GGQSRDSDQAPEDRWYEAEKVWLA-QKDGFTLATVLKPDEGTADLPAGRVRLWIDADKTITEVDE 601
            ||||..|:..          ||:. :|:.|....::..|...........::.|......|||..
Yeast     3 GGQSCSSNMI----------VWIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSN 57

Human   602 ------EHVHRANPPELDQVEDLASLISVNESSVLNTLLQRYKAQLLHTCTGPDLIVLQP----- 655
                  ..|...||...|:||:::.|..:||.|||..|.:||...|::|.:|..|:.:.|     
Yeast    58 LVQVRISDVFPVNPSTFDKVENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLN 122

Human   656 -----------RGPSVPSAGKVPKGRRDGLPAHIGSMAQRAYWALLNQRRDQSIVALGWSGAGKT 709
                       ...:..|..::.:...:.||.||.::|:.||..||::.:||||:..|.||||||
Yeast   123 LYSEDHINLYHNKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKT 187

Human   710 TCCEQVLEHLVGM-AGS------VDGRVSVE----KIRATFTVLRAFGSVSMAHSRSATRFSMVM 763
            ...:::|::|..: :||      |.|...||    ||..:..:|.:||:.....:.:::||...:
Yeast   188 ENTKKILQYLASITSGSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFI 252

Human   764 SLDFNATGRITAAQLQTMLLEKSRVARQPEGESNFLVFSQMLAGLD------LDLRTELNLHQMA 822
            .::||..|.|..|.::..||||||:..|...|.|:.:|.|:|:|||      |.|::. |:....
Yeast   253 KIEFNEHGMINGAHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSR-NVKDYK 316

Human   823 DSSSFGMGVWSKPEDKQKAAAAFAQLQGAMEMLGISESEQRAVWRVLAAIYHLGAAGACKVGRKQ 887
            ..|:....:.....|.:.    |.:|..|:.::|.|:.:.|.:::|:|.|        ..:|..:
Yeast   317 ILSNSNQDIIPGINDVEN----FKELLSALNIIGFSKDQIRWIFQVVAII--------LLIGNIE 369

Human   888 FM--RFEWANYAAEA------LGCEYEELNTATFKHHLRQIIQQMTFGPSRWGLEDEETSSGLKM 944
            |:  |.|.|::..:.      ||.:.::..||        |::..:.....| :...:.|...|.
Yeast   370 FVSDRAEQASFKNDVSAICSNLGVDEKDFQTA--------ILRPRSKAGKEW-VSQSKNSQQAKF 425

Human   945 TGVDCVEGMASGLYQELFAAVVSLINRSFSSHHLSMASIMVVDSPGFQNPRHQGKDRAATFEELC 1009
                .:..::..||:.||..:|.:||::......::..|.::|..||:...:.      :||:||
Yeast   426 ----ILNALSRNLYERLFGYIVDMINKNLDHGSATLNYIGLLDIAGFEIFENN------SFEQLC 480

Human  1010 HNYAHERLQLLFYQRTFVSTLQRYQEEGVPVQFDLPDPSPGTTVAVVDQNPSQQVRLPAGGGAQD 1074
            .||.:|:||..|....||.....|.:|.  :|:|           .:|.....|:.:........
Yeast   481 INYTNEKLQQFFNNHMFVLEQSEYLKEN--IQWD-----------YIDYGKDLQLTIDLIESKGP 532

Human  1075 ARGLFWVLDEEVHVEGSSDSVVLERLCAAFEKKGAGTEGSSALRTCEQPLQCEIFHQLGWDPVRY 1139
            ..|:..:||||..:..|:|.....:|.:.::      :.||..:.........:.|..|  .|.|
Yeast   533 PTGVLPLLDEEAVLPKSTDESFYSKLISTWD------QNSSKFKRSRLKNGFILKHYAG--DVEY 589

Human  1140 DLTGWLHRAK----PNLSALDAPQVLHQSKREELRSLFQARAKLPPVCRAVAGLEGT-SQQALQR 1199
            .:.|||.:.|    .||.:|     |..|:.:.:..|||...:.    .:.||:|.. |.|.:::
Yeast   590 TVEGWLSKNKDPLNDNLLSL-----LSSSQNDIISKLFQPEGEK----SSSAGVEANISNQEVKK 645

Human  1200 SRMVRRTFASSLAAVRRKAPCSQIKLQMDALTSMIKRSRLHFIHCLVPNPVVESRSGQESPPPPQ 1264
            |... .||         |...|:.:.|...|.:.:..:..||:.|::||.|.:.::....     
Yeast   646 SART-STF---------KTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRR----- 695

Human  1265 PGRDKPGAGGPLALDIPALRVQLAGFHILEALRLHRTGYADHMGLTRFRRQFQVL------DAPL 1323
                       |.||      ||....:||.:||.|.||.:.:....|.:::::|      ....
Yeast   696 -----------LILD------QLRCNGVLEGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTF 743

Human  1324 LKKLMSTSEGIDERKAVEELLETLDLEKKAVAVGHSQVFLKAGVISRLEKQREKLVSQSIVLFQA 1388
            ..||.:::     ::..|.||.:|.|:.|...:|::::|.||||::.||||::..::..::...|
Yeast   744 SSKLKAST-----KQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLEKQKDVKLNNIMIKLTA 803

Human  1389 ACKGFLSRQE----FKKLKIRRLAAQCIQKNVAVFLAVKDWPWWQLLGSLQPLLSATIGTEQLRA 1449
            ..:|:..|:|    .:|||..|:.....:....:   ||:.||:.|...::|||:::....:.:.
Yeast   804 TIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRL---VKEDPWFNLFIRIKPLLTSSNDMTRTKK 865

Human  1450 KEEELTTLRRKL-----------EKSEKLRNELRQNTDLLESKIADLTSDLADERFKGDVACQVL 1503
            ..|::..|:..|           ||::|..|||....|||..:..:|       |....:..:|.
Yeast   866 FNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDLLNQEKENL-------RKNESLLNRVK 923

Human  1504 ESERAERLQAFREVQELKSKHEQVQKKLGDVNKQLEEAQQKIQLNDLERNPTGGADEWQMRFDCA 1568
            .|  :|.||  ::..:|.|:.:::.::..:|.:.||||.||||                      
Yeast   924 TS--SETLQ--KQFDDLVSEKDEISREKLEVAQNLEEAHQKIQ---------------------- 962

Human  1569 QMENEFLRKRLQQCEERLDSELTARKELEQKLGEL----------QSAYDGAK-KMAHQLKRKCH 1622
                 .|::.:::.|..|:...:...||.:::.:|          ||....:| |:.:::||   
Yeast   963 -----GLQETIREREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKR--- 1019

Human  1623 HLTCDLEDTCVLLENQ-QSRNHELEKKQKKFDLQLAQALGESVFEKG-------LREKVTQ---- 1675
                 |:|.....|.: :|.|.:|...::..|::|.      ..||.       |:..||:    
Yeast  1020 -----LKDVINSKEEEIKSFNDKLSSSEEDLDIKLV------TLEKNCNIAMSRLQSLVTENSDL 1073

Human  1676 --ENTSVRWELGQLQQQLKQKEQEASQLKQQVEMLQDHKRELLGSPSLGENCV-------AGLKE 1731
              :|.:.:.|...|..|||.||.|..::|::::   :||:||.......::.|       |.|||
Yeast  1074 RSKNENFKKEKAALNNQLKNKESELLKMKEKID---NHKKELATFSKQRDDAVSEHGKITAELKE 1135

Human  1732 RLWKLESSALEQQKIQSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKR 1796
            ...:|.......|||:.:..|           |:.|   .|:..||.|....|.|.|      .:
Yeast  1136 TRIQLTEYKSNYQKIKEEYSN-----------FQRE---TKEQEQKKRNSLVESLND------SK 1180

Human  1797 LHQLEMQLEQEYEEKQMV----------------------LHEKQDLEGLIGTLCD-QIGHRDFD 1838
            :.:||.:|.||....|.:                      ..:..|.|.:|....| |:...  :
Yeast  1181 IKELEARLSQEISLNQYLNKRISGNSVETNISSTRRSTSYSDDPLDKEDIIKKYYDLQLAFT--E 1243

Human  1839 VEKRLRRDLRRTHALLS-----DVQLLLGTMEDGKTSVSKEELEKVHSQLEQS---EAKCEEALK 1895
            :.:.|..::.....|:|     :.:|...:.||.|.....::|:|:...::.|   ::...|.|.
Yeast  1244 ITRNLENEIEEKKNLISRLRFTETRLASSSFEDQKIKAQMKKLKKLIQDMDPSIPLDSILNEPLD 1308

Human  1896 ---------TQKVLTAD-------------------LESMHSELENMTRNKSLVDEQLYRLQFEK 1932
                     .:.:|..|                   :.::||:...:....||....:|:|:||.
Yeast  1309 NCPDKESDINKLMLEVDYLKRQLDIETRAHYDAENAISALHSKFRKIQGESSLSSSDIYKLKFEA 1373

Human  1933 ADLLKRIDEDQDDLNELMQKHK------DLIAQSAADIGQIQELQLQLEEAKKEKHKLQEQL--- 1988
            ::  :|:...:|.|..:..:.:      |:| ::...|.:.:|   ::...|.|.:||||.|   
Yeast  1374 SE--ERVKSLEDKLKTMPLRDRTNLPVGDII-KNRDSISKYEE---EIRYYKLENYKLQEILNES 1432

Human  1989 --QVAQMRIEYLEQSTVDRAIVSRQ-EAVICDLENKTEFQ--------KVQIKRFEVLV------ 2036
              :::|:.:: |.||....|::|.| :.:..|||: ||.|        |.|.::||..:      
Yeast  1433 NGKLSQLTLD-LRQSKSKEALLSEQLDRLQKDLES-TERQKELLSSTIKQQKQQFENCMDDLQGN 1495

Human  2037 -IRLRDSL--IKMGEE-------LSQAATSESQQRE------------SSQYYQRRLEELK--AD 2077
             :|||:.:  :|..||       :.:...::::|:|            |....|..|.|||  .|
Yeast  1496 ELRLREHIHALKQAEEDVKNMASIIEKLKTQNKQKEKLIWEREMERNDSDMQLQETLLELKRVQD 1560

Human  2078 MEELVQRE-AEASRRCMELE---KYVEELAAVRQTLQTDL--ETSIRR-IADLQAALEEVASSDS 2135
            :::::..: |....|...:|   :|.:|:..:::.|...|  ||:::: .|.|:..| |.:::||
Yeast  1561 VKKILSDDLAHLKERLSAVEDRSQYTDEINRLKEELNCSLKAETNLKKEFATLKYKL-ETSTNDS 1624

Human  2136 DTESVQTAVDCGSSGRKEMDN----VSILSSQPEGSLQSWLSCTLSLATDTMRTPSRQSATSSRI 2196
            :.:.        |...|::|:    |.:|:::.:         .:|||...:........|....
Yeast  1625 EAKI--------SDLLKQLDHYTKVVEMLNNEKD---------AISLAEKELYQKYEALNTECES 1672

Human  2197 LSPRI-------NEEAGDTERTQSALALSRARSTNVHSKTSGDKPVSPHFVRRQKYCHFGDGEVL 2254
            |..:|       .|...|..:...||.:|.|.   :.|.|..:|.::    .:.||..    |.|
Yeast  1673 LKGKIVSLTKIKQELESDLNQKTDALQISNAA---LSSSTQKNKEIT----EKIKYLE----ETL 1726

Human  2255 AVQRKSTER 2263
            .:|.:...|
Yeast  1727 QLQMEQNSR 1735

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYO18BXP_011528760.1 2A1904 <263..555 CDD:273344 5/16 (31%)
COG5022 552..2129 CDD:227355 412/1798 (23%)
MYSc_Myo18 627..1364 CDD:276837 191/788 (24%)
MYO1NP_011888.1 COG5022 2..1691 CDD:227355 432/1902 (23%)
Smc 1607..>1901 CDD:440809 32/158 (20%)

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