DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYO18B and Mhc

DIOPT Version :9

Sequence 1:XP_011528760.1 Gene:MYO18B / 84700 HGNCID:18150 Length:2610 Species:Homo sapiens
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:1988 Identity:479/1988 - (24%)
Similarity:866/1988 - (43%) Gaps:420/1988 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   519 RPRIRKENQDGPAPQ-----EEGKGGQSRDSDQAPEDRWYEAEK-VWLA-QKDGFTLATV--LKP 574
            :|...:|::| |.|.     |:.:..||:.         |:::| .|:. :|:|:.|..:  .|.
  Fly     3 KPVANQEDED-PTPYLFVSLEQRRIDQSKP---------YDSKKSCWIPDEKEGYLLGEIKATKG 57

Human   575 DEGTADLPAGRVRLWIDADKTITEVDEEHVHRANPPELDQVEDLASLISVNESSVLNTLLQRYKA 639
            |..:..|..|.||          ::..|.|.:.|||:.:::||:|.:..:|...||:.|.|||.|
  Fly    58 DIVSVGLQGGEVR----------DIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYA 112

Human   640 QLLHTCTGPDLIVLQP--RGPSVPS-AGKVPKG-RRDGLPAHIGSMAQRAYWALLNQRRDQSIVA 700
            :|::|.:|...:.:.|  |.|...: ..|:.:| ||:.:|.||.:::..||..:|....:||::.
  Fly   113 KLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLI 177

Human   701 LGWSGAGKTTCCEQVLEHL--VGMAGSVD----GRVSVE-KIRATFTVLRAFGSVSMAHSRSATR 758
            .|.||||||...::|:.:.  ||.:...|    .:.|:| ::..|..||.|||:.....:.:::|
  Fly   178 TGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSR 242

Human   759 FSMVMSLDFNATGRITAAQLQTMLLEKSRVARQPEGESNFLVFSQMLAG-----LDLDLRTELNL 818
            |...:.:.|..||::..|.::|.||||:||..|...|.::.:|.|:::|     .|:.|.|: |:
  Fly   243 FGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTD-NI 306

Human   819 HQMADSSSFGMGVWSKPEDKQKAAAAFAQLQGAMEMLGISESEQRAVWRVLAAIYHLGAAGACKV 883
            :.....|...:.|.|..:     |..|:....|.::||.::.|:..|:|:.||:.|:|.....:.
  Fly   307 YDYHIVSQGKVTVASIDD-----AEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQR 366

Human   884 GRKQFMR---FEWANYAAEALGCEYEELNTATFKHHLRQIIQQMTFGPSRWGLEDEETSSGLKMT 945
            ||::...   .|.....::..||:..||    :|:.|:..|:          :.:|..:.|..:.
  Fly   367 GREEQAEQDGEEEGGRVSKLFGCDTAEL----YKNLLKPRIK----------VGNEFVTQGRNVQ 417

Human   946 GV-DCVEGMASGLYQELFAAVVSLINRSFSSHHLSMASIMVVDSPGFQNPRHQGKDRAATFEELC 1009
            .| :.:..:..|::..||..:|...|.:..:.......|.|:|..||:...:.|      ||:||
  Fly   418 QVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG------FEQLC 476

Human  1010 HNYAHERLQLLFYQRTFVSTLQRYQEEGVPVQF-----DLPDPSPGTTVAVVD--QNPSQQVRLP 1067
            .|:.:|:||..|....||...:.|:.||:...|     ||        :|.:|  :.|       
  Fly   477 INFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDL--------LACIDLIEKP------- 526

Human  1068 AGGGAQDARGLFWVLDEEVHVEGSSDSVVLERLCAAFEKKGAGTEGSSALRTCEQPLQCEIFHQL 1132
                    .|:..:|:||.....::|....|:|......|.|..:.....:..:|.....|.|..
  Fly   527 --------MGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYA 583

Human  1133 GWDPVRYDLTGWLHRAKPNLSALDAPQVLHQSKREELRSLFQARAKLPPVCRAVAGLEGTSQQAL 1197
            |.  |.|::||||.:.|..|:    ..|:.|.|:.:.:.|.:..|.       .||..|..:|| 
  Fly   584 GC--VSYNITGWLEKNKDPLN----DTVVDQFKKSQNKLLIEIFAD-------HAGQSGGGEQA- 634

Human  1198 QRSRMVRRTFASSLAAVRRKAPCSQIKLQMDALTSMIKRSRLHFIHCLVPNPVVESRSGQESPPP 1262
               :..|.......|.|     .|..|.|:::|.:.::.::.||:.|::||.:            
  Fly   635 ---KGGRGKKGGGFATV-----SSAYKEQLNSLMTTLRSTQPHFVRCIIPNEM------------ 679

Human  1263 PQPGRDKPGAGGPLALDIPALRVQLAGFHILEALRLHRTGYADHMGLTRFRRQFQVLDAPLLKKL 1327
            .|||          .:|...:..||....:||.:|:.|.|:.:.|....|:.:::::...||   
  Fly   680 KQPG----------VVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL--- 731

Human  1328 MSTSEGID-ERKAVEELLETLDLEKKAVAVGHSQVFLKAGVISRLEKQREKLVSQSIVLFQAACK 1391
                :|:: ::||.|.:::.:||.:....:|:::||.:|||:.::|:.|::.:.:.:...||..:
  Fly   732 ----QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792

Human  1392 GFLSRQEFKKLKIRRLAAQCIQKNVAVFLAVKDWPWWQLLGSLQPLLSATIGTEQLRAKEEELTT 1456
            |:|||:.||||:.:|:|.:.:|:|:..:|.::.|||::|...::|||:.:       ..|:|:..
  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVS-------RIEDEIAR 850

Human  1457 LRRKLEKSE-------KLRNELRQ-NTDLLESKIADLTSDLADERFKGDVACQVLESERAERLQA 1513
            |..|.:|:|       |:|.||.. |..||..|.| |...|:.|  ||  |.|..: ||..:|.|
  Fly   851 LEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTA-LLDSLSGE--KG--ALQDYQ-ERNAKLTA 909

Human  1514 --------FREVQELKSKHEQVQKKLGDVNKQLEEAQQKI-----QLNDLERNPTGGADEWQMRF 1565
                    .|::||..::.|..:.:|   .:|.::|.|:|     .:.|||.| ...|::.:...
  Fly   910 QKNDLENQLRDIQERLTQEEDARNQL---FQQKKKADQEISGLKKDIEDLELN-VQKAEQDKATK 970

Human  1566 DCAQMENEFLRKRLQQCEE---RLDSELTARKELEQKLG-ELQSAYDGAKKMAH--QLKRKCHHL 1624
            | .|:.|  |...:...:|   :|:.|...:.|..||.| |||:|.|   |:.|  ::|.|....
  Fly   971 D-HQIRN--LNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAED---KINHLNKVKAKLEQT 1029

Human  1625 TCDLEDTCVLLENQQSRNHELEKKQKKF--DLQLAQALGESVFEKGLREKVTQENTSVRWELGQL 1687
            ..:|||:   ||.::....::||.::|.  ||:|.|   |:|.:....:|             :|
  Fly  1030 LDELEDS---LEREKKVRGDVEKSKRKVEGDLKLTQ---EAVADLERNKK-------------EL 1075

Human  1688 QQQLKQKEQEASQLKQQVE----MLQDHKRELLGSPSLGENCVAGLKERLWKLESSALEQQKIQS 1748
            :|.:::|::|.|.:..::|    ::..|:|::       :...|.::|...::|:....:.|.:.
  Fly  1076 EQTIQRKDKELSSITAKLEDEQVVVLKHQRQI-------KELQARIEELEEEVEAERQARAKAEK 1133

Human  1749 QQENTIKQLEQLRQRFE---------LEIERMKQMH-QKDREDQEE-------ELEDVRQSCQKR 1796
            |:.:..::||:|.:|.|         :|:.:.::.. .|.|.|.||       .|.::|:.....
  Fly  1134 QRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDA 1198

Human  1797 LHQLEMQLEQEYEEKQMVLHEKQDLEGLIGTLCDQIGH--RDFDVEKRLRRDLRRTHALLSDVQL 1859
            :.::..|::|..:.|.....||.:..|.:..|...:.|  .:...::::.:.|:.|   |::||.
  Fly  1199 VAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHT---LNEVQS 1260

Human  1860 LLG----TMEDGKTSVSKEELEK--VHSQLEQSEAKCEEALKTQKVLTADLESMHSELENMTRNK 1918
            .|.    |:.|...|..|..:|.  :..|||::|::..:..|.:..||..||.          .|
  Fly  1261 KLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLED----------TK 1315

Human  1919 SLVDEQLYRLQFEKADLL---KRIDEDQDDLNELMQKHKDLIAQSAADIGQIQELQLQL------ 1974
            .|.||:    ..|:|.||   :.::.|.|:|.|.:::.    |:..||      ||.||      
  Fly  1316 RLADEE----SRERATLLGKFRNLEHDLDNLREQVEEE----AEGKAD------LQRQLSKANAE 1366

Human  1975 ----------------EEAKKEKHKLQEQLQVAQMRIEYLEQSTVD---------------RAIV 2008
                            ||.::.|.|||.:|..|:..||.|.|..:.               :..|
  Fly  1367 AQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEV 1431

Human  2009 SRQEAVICDLENKTE-FQKVQIKRFEVLVIRLRDSLIKMGEELSQAATSESQQRESSQY------ 2066
            .|..|:....|.|.: |.|: |..:::.|    |.|         ||..::.|:|...|      
  Fly  1432 DRANAIANAAEKKQKAFDKI-IGEWKLKV----DDL---------AAELDASQKECRNYSTELFR 1482

Human  2067 ----YQRRLEELKA----------DMEELVQREAEASRRCMELEKYVEELAAVRQTLQTDLETSI 2117
                |:...|:|:|          ::::|:.:..|..|...|:||..:.|.|.:..||..||   
  Fly  1483 LKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALE--- 1544

Human  2118 RRIADLQAALEE----VASSDSDTESVQTAVDCG-SSGRKEMDNVSILSSQPEGSLQSWLSCTLS 2177
                :.:||||:    |..:..:...|:..:|.. ....:|.:|......:...|:|:.|.....
  Fly  1545 ----EAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAK 1605

Human  2178 LATDTMRTPSRQSATSSRI---------------------------LSPRINEE--AGDTERTQS 2213
            ...:.:|...:..|..:.:                           :...:.||  |.|..|.|.
  Fly  1606 GKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQL 1670

Human  2214 ALALSRARSTNVHSKTSGDKPVSPHFVRRQKYCHFGD------------GEVLAVQRKSTERLEP 2266
            .::..||.:.....:.|..........|||......|            ..:.|.:||....|:.
  Fly  1671 GISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQT 1735

Human  2267 ASSPLASRSTNTSPLSREKLPSPSAALSEFVEGLRRKR 2304
            ..|.| ....|.:..|.||........:...:.||.::
  Fly  1736 LHSDL-DELLNEAKNSEEKAKKAMVDAARLADELRAEQ 1772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYO18BXP_011528760.1 Glutenin_hmw <114..542 CDD:281191 7/27 (26%)
MYSc 608..1376 CDD:214580 203/795 (26%)
MYSc_Myo18 627..1364 CDD:276837 192/764 (25%)
Smc 1457..>2133 CDD:224117 195/798 (24%)
GBP_C <1723..1818 CDD:303769 21/111 (19%)
coiled coil 1789..1803 CDD:293879 1/13 (8%)
RILP-like 1923..>2020 CDD:304877 31/136 (23%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 11/46 (24%)
MYSc 81..777 CDD:214580 203/795 (26%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 192/764 (25%)
Myosin_tail_1 842..1897 CDD:279860 231/1029 (22%)
V_Alix_like 1557..1877 CDD:187408 35/217 (16%)
ATP-synt_B <1671..1771 CDD:304375 19/100 (19%)
TMPIT 1739..>1825 CDD:285135 7/35 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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