Protein Alignment MYO18B and myo-1

DIOPT Version :10

• Sequence 1: XP_011528760.1
• Gene: MYO18B / 84700
• HGNCID: 18150
• Length: 2610
• Species: Homo sapiens
• Sequence 2: NP_492053.1
• Gene: myo-1 / 172471
• WormBaseID: WBGene00002348
• Length: 1938
• Species: Caenorhabditis elegans
• Alignment Length: 2004
• Identity: 454/2004 - (22%)
• Similarity: 806/2004 - (40%)
• Gaps: 462/2004 - (23%)

Human   534 EEGKGGQ----SRDSDQAPEDRWYEAEK-VWLAQKDGFTLATVLK---PDEGTADLPAGRVRLWI 590
            |:..|.|    ||:...|.:.|.|:::| ||:...:...:..|:|   |...|..:.||
 Worm     6 EKDPGWQYLKRSREQQLADQSRPYDSKKNVWIPDAEEGYIEGVIKGPGPKADTVIVTAG------ 64

Human   591 DADKTITEVDEEHVHRANPPELDQVEDLASLISVNESSVLNTLLQRYKAQLLHTCTGPDLIVLQP 655
              .|.:| :.::.|...|||:.::.||:::|..:|::|||..|..||.|.|::|.:|...:|:.|
 Worm    65 --GKDVT-LKKDIVQEVNPPKFEKTEDMSNLTFLNDASVLWNLRSRYAAMLIYTYSGLFCVVINP 126

Human   656 --RGP-SVPSAGKVPKG-RRDGLPAHIGSMAQRAYWALLNQRRDQSIVALGWSGAGKTTCCEQVL 716
              |.| ...|..::..| ||..:|.|:.:::.:||..:|....:||::..|.||||||...::|:
 Worm   127 YKRLPIYTDSVARMFMGKRRTEMPPHLFAVSDQAYRYMLQDHENQSMLITGESGAGKTENTKKVI 191

Human   717 EHLVGMAGS-----VDGRVSV---EKIRATFTVLRAFGSVSMAHSRSATRFSMVMSLDFNATGRI 773
            .:...:..|     .:|...|   ::|..|..||.|||:.....:.:::||...:.:.||..|.:
 Worm   192 CYFATVGASQKAALKEGEKEVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNKHGTL 256

Human   774 TAAQLQTMLLEKSRVARQPEGESNFLVFSQMLAGLDLDLRTELNLHQ-------MADSSSFGMGV 831
            .:..::..|||||||.||..||..:.:|.|:.:.....||.||.|:.       :|.:.....|:
 Worm   257 ASCDIEHYLLEKSRVIRQAPGERCYHIFYQIYSDFKPQLRDELLLNHPISNYWFVAQAELLIDGI 321

Human   832 WSKPEDKQKAAAAFAQLQGAMEMLGISESEQRAVWRVLAAIYHLGAAGACKVGRKQFMRFEW--- 893
                :|.::    |.....|.::|..|.:|:...:|:::|..|:|     .:..||..|.|.
 Worm   322 ----DDTEE----FQLTDEAFDVLKFSPTEKMDCYRLMSAHMHMG-----NMKFKQRPREEQAEP 373

Human   894 -----ANYAAEALGCEYEELNTATFKHHLRQIIQQMTFGPSRWGLEDEETSSGLKMTGVD-CVEG 952
                 |..|....|.:.::.        |:.::.......:.|      .|.|..:..|. .:..
 Worm   374 DGQDEAERACNMYGIDVDQF--------LKALVSPRVKVGTEW------VSKGQNVDQVHWAIGA 424

Human   953 MASGLYQELFAAVVSLINRSFSSHHLSM-ASIMVVDSPGFQ----NPRHQGKDRAATFEELCHNY 1012
            ||.|||..:|..:|...|.:.....:.. ..|.|:|..||:    |          :||:|..|:
 Worm   425 MAKGLYARVFHWLVKKCNLTLDQKGIDRDYFIGVLDIAGFEIFDFN----------SFEQLWINF 479

Human  1013 AHERLQLLFYQRTFVSTLQRYQEEGVPVQF-----DLPDPSPGTTVAVVDQNPSQQVRLPAGGGA 1072
            .:|:||..|....||...:.|..||:...|     ||             |...:.:..|.
 Worm   480 VNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDL-------------QACIELIEKPL---- 527

Human  1073 QDARGLFWVLDEEVHVEGSSDSVVLERLC-------AAFEK----KGAGTEGSSALRTCEQPLQC 1126
                |:..:||||..|..::|..:.::|.       ..|||    ||...|...|:|
 Worm   528 ----GIISMLDEECIVPKATDMTLAQKLTDQHLGKHPNFEKPKPPKGKQGEAHFAMR-------- 580

Human  1127 EIFHQLGWDPVRYDLTGWLHRAKPNLSALDAPQVLHQSKREELR-SLFQ---ARAKLPPVCRAVA 1187
               |..|  .|||::..||.:.|..|:. ....|:..||:.:|. .::|   .:.:.....:|..
 Worm   581 ---HYAG--TVRYNVLNWLEKNKDPLND-TVVSVMKASKKNDLLVEIWQDYTTQEEAAAAAKAGG 639

Human  1188 GLEGTSQQALQRSRMVRRTFASSLAAVRRKAPCSQIKLQMDALTSMIKRSRLHFIHCLVPNPVVE 1252
            |.:|....:.....|:.|.                   .::.|.:|:.::..|||.|::||.  :
 Worm   640 GRKGGKSGSFMTVSMMYRE-------------------SLNKLMTMLHKTHPHFIRCIIPNE--K 683

Human  1253 SRSGQESPPPPQPGRDKPGAGGPLALDIPALRVQLAGFHILEALRLHRTGYADHMGLTRFRRQFQ 1317
            .:||.                    :|...:..||....:||.:|:.|.|:.:......|.:::.
 Worm   684 KQSGM--------------------IDAALVLNQLTCNGVLEGIRICRKGFPNRTQHPDFVQRYA 728

Human  1318 VLDAPLLKKL--MSTSEGIDERKAVEELLETLDLEKKAVAVGHSQVFLKAGVISRLEKQREKLVS 1380
            :|.|...|..  |.|..|    ..::.|:....|..:...:||::||.||||::.:|..|:..::
 Worm   729 ILAAKEAKSSDDMKTCAG----AILQALINQKQLNDEQFRIGHTKVFFKAGVVAHIEDLRDDKLN 789

Human  1381 QSIVLFQAACKGFLSRQEFKKLKIRRLAAQCIQKNVAVFLAVKDWPWWQLLGSLQPLLSATIGTE 1445
            |.|..||:|.:.:.:..:....:.:..:...:|:|:..:..::.|.|:.|.|.|:|.|......|
 Worm   790 QIITGFQSAIRWYTATADAGARRKQLNSYIILQRNIRSWCVLRTWDWFLLFGKLRPQLKCGKMAE 854

Human  1446 QLRAKEEELTTLRRKLEKSEKLRN--------------------ELRQ-NTDLLESKIADLTSDL 1489
            ::....||...|..:.:|:|..|.                    ||.| .:..:|.|:..|.|..
 Worm   855 EMIKMAEEQKVLEAEAKKAESARKSQEEAYAKLSAERSKLLEALELTQGGSAAIEEKLTRLNSAR 919

Human  1490 AD-ERFKGDVACQVLESE------RAERLQAFREVQELKSKHEQVQKKLGDVNKQLEE------- 1540
            .: |:...|...::.|.|      ..:|.:|.:||:.||...|.|.   |::.|.|||
 Worm   920 QEVEKSLNDANDRLSEHEEKNADLEKQRRKAQQEVENLKKSIEAVD---GNLAKSLEEKAAKENQ 981

Human  1541 ---AQQKIQLND------------LERNPTGGADEWQMRFDCAQMENEFLRKRLQQ----CEERL 1586
               .|.::...|            ||.|.....|:.|.. :..|.:...||.:|:|    .||.:
 Worm   982 IHSLQDEMNSQDETIGKINKEKKLLEENNRQLVDDLQAE-EAKQAQANRLRGKLEQTLDEMEEAV 1045

Human  1587 DSELTARKELEQKLGELQSAYDGAKKMAHQ-----------LKRKCHHLTCDLEDTCVLLENQQS 1640
            :.|...|.|.|:...:::....||::...:           ||:|    ..|:....|.:|::|:
 Worm  1046 EREKRIRAETEKSKRKVEGELKGAQETIDELSAIKLETDASLKKK----EADIHALGVRIEDEQA 1106

Human  1641 RNHELEKKQKKFDLQLAQALGESVFEKGLREKVTQENTSVRWELGQLQQQL----KQKE-QEASQ 1700
            ..:.|.::.|:...::.:...|...|:..|.|..:....::.||.:|.::|    ||.| |:.:.
 Worm  1107 LANRLTRQSKENAQRIIEIEDELEHERQSRSKADRARAELQRELDELNERLDEQNKQLEIQQDNN 1171

Human  1701 LKQQVEMLQDHKRELLGSPSLGENCVAGLKERLWKLESSALEQQKIQSQQENTIKQLEQLRQRFE 1765
            .|:..|::: .:|:|.......|:.:|.::.:         ...:| |...||:..|    |:.:
 Worm  1172 KKKDSEIIK-FRRDLDEKNMANEDQMAMIRRK---------NNDQI-SALTNTLDAL----QKSK 1221

Human  1766 LEIERMKQMHQKDREDQEEELEDVRQSCQKRLHQLEMQLEQEYEEKQMVLHEKQDLEGLIGTLCD 1830
            .:||:.|.:.||:.:|...:::   |..:.|:.|  .:|.::||.:...|.:|.|.:.      .
 Worm  1222 AKIEKEKGVLQKELDDINAQVD---QETKSRVEQ--ERLAKQYEIQVAELQQKVDEQS------R 1275

Human  1831 QIGHRDFDVEKRLRRDLRRTHALLSDVQLLLGTMEDGKTSVSKEELEKVHSQLEQSEAKCEEALK 1895
            |||... ..:.||..|.......:.::::.|.|:...||:.|        |||.:::...|:.|.
 Worm  1276 QIGEYT-STKGRLSNDNSDLARQVEELEIHLATINRAKTAFS--------SQLVEAKKAAEDELH 1331

Human  1896 TQ-------KVLTADLESMHSELENMTRNKSLVDEQLYRLQFEKADLLKRIDED----QDDLNEL 1949
            .:       |.|..:|:..|..||.....|..:..||.|:..|.:....|.:.:    .::|.||
 Worm  1332 ERQEFHAACKNLEHELDQCHELLEEQINGKDDIQRQLSRINSEISQWKARYEGEGLVGSEELEEL 1396

Human  1950 MQKHKDLIAQSAADIGQIQELQLQLEEAKKEKHKLQEQLQVAQMRIEYLEQS-------TVD-RA 2006
            .:|..:.:..                        |||.|..||.::..||::       |.| |:
 Worm  1397 KRKQMNRVMD------------------------LQEALSAAQNKVISLEKAKGKLLAETEDARS 1437

Human  2007 IVSRQEAVICDLENKTE-FQKV--------------------QIKRFEVLVIRLRDSLIKMGEEL 2050
            .|.|...||..||.|.. |.|:                    ..:.....|.:||.|:..:.|::
 Worm  1438 DVDRHLTVIASLEKKQRAFDKIVDDWKRKVDDIQKEIDATTRDSRNTSTEVFKLRSSMDNLSEQI 1502

Human  2051 ----------SQAATSESQQ-RESSQYYQ------RRLEELKADMEELVQREAEASRRC------ 2092
                      ||.....::| .:..:.||      ||||:.|.:::..:. ||||:...
 Worm  1503 ETLRRENKIFSQEIRDINEQITQGGRTYQEVHKSVRRLEQEKDELQHALD-EAEAALEAEESKVL 1566

Human  2093 ----------MELEKYV----EELAAVR-------QTLQTDLETSIRRIADLQAALEEVASSDSD 2136
                      .|:||.:    ||....|       :::|..|||..:..|:|..|.:::   ::|
 Worm  1567 RLQIEVQQIRSEIEKRIQEKEEEFENTRKNHQRALESIQASLETEAKSKAELARAKKKL---ETD 1628

Human  2137 TESVQTA--------VDCGSSGRKEMDNVSILSSQ-------PEGSLQSWLSCTLSLATDTMRTP 2186
            ...::.|        ||...:.:|..|.|..|..|       .|...:::|:....||.
 Worm  1629 INQLEIALDHANKANVDAQKNLKKLFDQVKELQGQVDDEQRRREEIRENYLAAEKRLAI------ 1687

Human  2187 SRQSATSSRILSPRINEEAGDTERTQSALALSRARSTNVHSKTSGDKPVSPHFVRRQKYCHFGDG 2251
               :.:.|..|:.||  ||.|..:.|..:..:..:|:|...                    .|:.
 Worm  1688 ---ALSESEDLAHRI--EASDKHKKQLEIEQAELKSSNTEL--------------------IGNN 1727

Human  2252 EVL-AVQRKSTERLEPASSPLASRSTNTSPLSREKLPSPSAALSEFVEGLRRKR 2304
            ..| |::||....::.|.:.| ....|....|.|:....:|......|.:|:::
 Worm  1728 AALSAMKRKVENEVQIARNEL-DEYLNELKASEERARKAAADADRLAEEVRQEQ 1780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO18B	XP_011528760.1	2A1904	<263..555	CDD:273344	8/24 (33%)
		COG5022	552..2129	CDD:227355	411/1789 (23%)
		MYSc_Myo18	627..1364	CDD:276837	188/791 (24%)
myo-1	NP_492053.1	Myosin_N	30..73	CDD:460670	11/51 (22%)
		MYSc_class_II	98..773	CDD:276951	188/791 (24%)
		Myosin_tail_1	854..1919	CDD:460256	219/1030 (21%)