|
Human 1 MAISSRLALWEQKIREEDKSPPPSS-PPPLFSVIPGGFIKQLVRGTEKEAKEARQRKQLAVASPE 64
||:||||.||||||:||.|:|..:: |||..|.:||||:|||||.||||.: .
Zfish 1 MALSSRLKLWEQKIKEEKKAPEAAAQPPPPLSAVPGGFLKQLVRETEKETR-------------H 52
Human 65 REVETEAKRGQVIFPRSSDQIEAERGGEPVCSLLSQDAWKRTSLIPEISISQPNSKSSSGTRSGS 129
|| |||...:|.||.|... .
Zfish 53 RE-------------------------------------------PEIKEDKPPSKLSDNL---V 71
Human 130 QQISQDDQSSSPGSSDILGKESEGS-RSPDPEQMTSINGEKAQELGSSATPTKKTVPFKRGVRRG 193
|.....|: :..|| |:|.| |:..| :|||:.:.:..|
Zfish 72 QNFLLPDE-----TPPIL--EAEMSLRAEQP-----VNGERGRHIAMS----------------- 107
Human 194 DVLLMVAKLDPDSAKPEKTHPHDAPPCKTSPP----ATDTGKEKKGETSRTPCGSQASTEILAPK 254
|| |||.| :.:..|..:.||. .|..:.|.:...|:
Zfish 108 ----------------EK---------KTSSPRRIISPENPKSPRAETQ--TCSPEVSPDTHTPQ 145
Human 255 AEKTRTGGLGDPGQGTVALKKGEEGQSIVGKGLGTPKTTELKEAEPQGKDRQGTRPQAQGPGEGV 319
.|: :...|:||:|..::.:|.|.
Zfish 146 KEE---------------------------------QVKMLQEAQPPKQEVKGVRQ--------- 168
Human 320 RPGKAEKEGAEPTNTVEKGNVSKDVGSEGKHVRPQIPGRKWGGFLGRRSKWDGPQNKKDKEGVLL 384
Zfish 169 ----------------------------------------------------------------- 168
Human 385 SKAEKTGEPQTQMEKTSQVQGELGDDLRMGEKAGELRSTTGKAGESWDKKEKMGQPQGKSGNAGE 449
||:.|:
Zfish 169 -------EPEGQI---------------------------------------------------- 174
Human 450 ARSQTEKGCEAPKEVSTMVESPAAPGKGGWPGSRGQEAEEPCSRAGDGAGALETELEGPSQPALE 514
.|:.|.|....|.|
Zfish 175 -------------TVTHMKEESKVPVK-------------------------------------- 188
Human 515 KDAERPRIRKENQDGPAPQEEGKGGQSRDSDQAPEDRWYEAEKVWLAQKDGFTLATVLKPDEGTA 579
|.||||.:||...|||:||||.|||||||.
Zfish 189 -----------------------------------DVWYEAGQVWFTHKDGYTLATQLKPDEGTP 218
Human 580 DLPAGRVRLWIDADKTITEVDEEHVHRANPPELDQVEDLASLISVNESSVLNTLLQRYKAQLLHT 644
:||.||||:.:.:|::|.:|.:..:.:.||||||..|||:.|:||||||.|:||..|.||.|..|
Zfish 219 ELPDGRVRVRLSSDQSIHDVSQYEIEKLNPPELDLCEDLSDLVSVNESSALHTLSSRAKAHLPLT 283
Human 645 CTGPDLIVLQPRGPSVPSAGKVPKGRR---DGLPAHIGSMAQRAYWALLNQRRDQSIVALGWSGA 706
..||:|:.| .|.|.|:.|..:.|| ...|..:.::.::.|.::|.|||||::||||.||:
Zfish 284 HAGPNLLAL---WPPVSSSTKSFRSRRWESWEAPGPLQAVVRKVYVSMLGQRRDQTLVALGRSGS 345
Human 707 GKTTCCEQVLEHLVGMAGSVDGRVSVEKIRATFTVLRAFGSVSMAHSRSATRFSMVMSLDFNATG 771
||||.|:.....|:..||:..|.:::|:::|.|||||:||.||..||.:::||:||:|:|||..|
Zfish 346 GKTTACQSFSLELLKQAGTAGGSLTLERLQAVFTVLRSFGCVSSTHSEASSRFAMVLSVDFNHAG 410
Human 772 RITAAQLQTMLLEKSRVARQPEGESNFLVFSQMLAGLDLDLRTELNLHQMADSSSFGMGVWSKPE 836
...||.||||||||.||.::|:||||||||||||:||..||||||.|||:.:.:.||:...:|.:
Zfish 411 LAAAAHLQTMLLEKWRVCQRPDGESNFLVFSQMLSGLSSDLRTELQLHQLKEHNFFGITCPTKVD 475
Human 837 DKQKAAAAFAQLQGAMEMLGISESEQRAVWRVLAAIYHLGAAGACKVGRKQFMRFEWANYAAEAL 901
:||:||..|.:|..||..||.|..||:|:|||||.|||||.||.|||||||||.|:.|..|:..|
Zfish 476 EKQRAAVGFGKLLAAMNTLGFSSDEQKAIWRVLAGIYHLGVAGTCKVGRKQFMSFDSAQTASAML 540
Human 902 GCEYEELNTATFKHHLRQIIQQMTFGPSRWGLEDEETS----SGLKMTGVDCVEGMASGLYQELF 962
|||.|||:||.|||||||::|: :..|:.:.:|: .|.|:|...||||||:|||:|||
Zfish 541 GCEGEELHTAVFKHHLRQLLQR-----ASGGIRERQTAEQHDDGPKLTAAQCVEGMAAGLYEELF 600
Human 963 AAVVSLINRSFSSHHLSMASIMVVDSPGFQNPRHQGKDRAATFEELCHNYAHERLQLLFYQRTFV 1027
.||||||||:..|..|::||:||||:||.:||||..::|||.|.||||||..|||....|..||.
Zfish 601 TAVVSLINRTLCSQQLTLASVMVVDAPGLRNPRHSAEERAAGFSELCHNYLQERLLEHHYTHTFT 665
Human 1028 STLQRYQEEGVPVQFDLPDPSPGTTVAVVDQNPSQQVRLPAGGGAQDARGLFWVLDEEVHVEGSS 1092
.||.||.:|||||.|..|:.||...|..:|| |..||| |...|:|||.||||||:...|||
Zfish 666 QTLDRYTQEGVPVDFSAPESSPSEVVCAIDQ-PGLQVR----GPEADSRGLLWVLDEELSTAGSS 725
Human 1093 DSVVLERLCAAFEKKGAGTEGSSALRTCEQPLQCEIFHQLGWDPVRYDLTGWLHRAKPNLSALDA 1157
:||||||:|..| ||.:|.|||||||||.|.:|.|.|||||:||....:.|.|.|:|
Zfish 726 ESVVLERVCQYF---------SSTVRQCEQPLQCEIAHLMGSDAVRYDLSGWFSLLQNNPSLLNA 781
Human 1158 PQVLHQSKREELRSLFQARAKLPPVCRAVAGLEGTSQQALQRSRMVRRTFASSLAAVRRKAPCSQ 1222
..:||.|....:::||..||.:||:||.:.|:||.||::|:||..||:|.::.:||:||.:.|..
Zfish 782 SSLLHNSSHMSVKALFGPRASVPPLCRGLGGVEGGSQRSLERSGAVRKTLSAGMAALRRHSHCIS 846
Human 1223 IKLQMDALTSMIKRSRLHFIHCLVPNPVVESRSGQESPPPPQPGRDKPGAGGPLALDIPALRVQL 1287
||||.|||.|:|:|:|..|:.|| ..|...|| .|:||||:||
Zfish 847 IKLQADALLSVIRRARPVFLQCL---------------------SVKTDGGG---FDVPALRIQL 887
Human 1288 AGFHILEALRLHRTGYADHMGLTRFRRQFQVLDAPLLKKLMSTSEGIDERKAVEELLETLDLEKK 1352
...|:|..|:|:||||.:||.|:.||.:||.|.||::|:..|.....||||||||||..|||:||
Zfish 888 NSTHLLPTLQLYRTGYPEHMSLSDFRCRFQALSAPVMKRYGSVFITPDERKAVEELLIDLDLDKK 952
Human 1353 AVAVGHSQVFLKAGVISRLEKQREKLVSQSIVLFQAACKGFLSRQEFKKLKIRRLAAQCIQKNVA 1417
:|.:|.|:||:|.||:..|::||::|:|..:|..||:|.|.|.|.:::::|::::|.:|:|:||.
Zfish 953 SVVLGASRVFMKRGVLRSLDQQRDQLLSGWLVQLQASCLGHLGRLKYRRMKVQQMAVRCVQRNVR 1017
Human 1418 VFLAVKDWPWWQLLGSLQPLLSATIGTEQLRAKEEELTTLRRKLEKSEKLRNELRQNTDLLESKI 1482
|..||..|.||:||..::|||...:..::||:||:|:|.|||:||||||.||||||..|.||:|:
Zfish 1018 VLSAVSRWSWWKLLCRVRPLLDVNMDDQRLRSKEDEITALRRRLEKSEKERNELRQTADNLETKV 1082
Human 1483 ADLTSDLADERFKGDVACQVLESERAERLQAFREVQELKSKHEQVQKKLGDVNKQLEEAQQKIQL 1547
..:.|:|:||||:|:...|.|::||.|||:..:|.:||:|:.||.:..|..:.:||||.:||::
Zfish 1083 TAVISELSDERFRGEAMSQALDAERTERLRLAKESKELQSRVEQSKVSLEALERQLEEEKQKVK- 1146
Human 1548 NDLERNPTGGADEWQMRFDCAQMENEFLRKRLQQCEERLDSELTARKELEQKLGELQSAYDGAKK 1612
|...........|.|::.:|||.|.||||:||:|.||||:.|...|:.||.|:.:|||..|.:|:
Zfish 1147 NKEALCGVATESELQLQLECAQTEVEFLRRRLRQTEERLEGEKEGRQLLETKVQDLQSQLDQSKR 1211
Human 1613 MAHQLKRKCHHLTCDLEDTCVLLENQQSRNHELEKKQKKFDLQLAQALGESVFEKGLREKVTQEN 1677
...:|||.|..||.||:|..||.::.|||.|||::||::||.:|.|||..:..|:..:|:|..||
Zfish 1212 TVTELKRHCRRLTSDLQDARVLTDSLQSRAHELDRKQRRFDSELTQALTHADNEREQKERVIHEN 1276
Human 1678 TSVRWELGQLQQQLKQKEQEASQLKQQVEMLQDHKRELLGSPSLGENCVAGLKERLWKLESSALE 1742
|::..|:..|::.||:.|.|...|:|..|.|....|:|.....|..:.|..||:.|.:|||...|
Zfish 1277 TTLGAEIFTLRKTLKESETEVQHLQQLKEELSCQIRDLSVPLKLTSDSVPELKKHLRELESRDKE 1341
Human 1743 QQKIQSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKRLHQLEMQLEQE 1807
:.:..||....|.|.||:..|||:|:|||||:|||:.||::||||||::|.|:||.|||||||||
Zfish 1342 RSEEISQMTARITQHEQMHLRFEMEMERMKQIHQKELEDKDEELEDVQKSSQRRLRQLEMQLEQE 1406
Human 1808 YEEKQMVLHEKQDLEGLIGTLCDQIGHRDFDVEKRLRRDLRRTHALLSDVQLLLGTME---DGKT 1869
|||||||:|||.||||||.|||:|:|||||||||||||||:||||||||.||||.|:| .|..
Zfish 1407 YEEKQMVVHEKHDLEGLIATLCEQVGHRDFDVEKRLRRDLKRTHALLSDAQLLLSTVEQPGQGHD 1471
Human 1870 SVSKEELEKVHSQLEQSEAKCEEALKTQKVLTADLESMHSELENMTRNKSLVDEQLYRLQFEKAD 1934
..::|:|:::..|||.|||:..||...||.|.|:||:...||||:.:.|||.||.|.:|::|:.|
Zfish 1472 PGAQEQLQRLRCQLEDSEARRLEAEGVQKTLAAELENAQIELENICKQKSLADEDLSQLRYERTD 1536
Human 1935 LLKRIDEDQDDLNELMQKHKDLIAQSAADIGQIQELQLQLEEAKKEKHKLQEQLQVAQMRIEYLE 1999
|:||::|||:||||||:|||.|||||::||.||:|||.::||.||::..||::||.:..|:::||
Zfish 1537 LMKRLEEDQEDLNELMKKHKALIAQSSSDISQIRELQAEMEELKKQRQTLQKELQTSVSRVQFLE 1601
Human 2000 QSTVDRAIVSRQEAVICDLENKTEFQKVQIKRFEVLVIRLRDSLIKMGEELSQAATSESQQRESS 2064
.|||.|:|||:|||.|||||||.|||:.|:|||:|||:|||||::::||||.|||.:|:::||:.
Zfish 1602 SSTVSRSIVSKQEARICDLENKLEFQRGQVKRFQVLVLRLRDSVVRLGEELEQAAQAEARERENC 1666
Human 2065 QYYQRRLEELKADMEELVQREAEASRRCMELEKYVEELAAVRQTLQTDLETSIRRIADLQAALEE 2129
:|||:|||:::.:||:|..||.::|||.||||..||||:|||||||.|||||||||.||||||||
Zfish 1667 RYYQQRLEDMRMEMEDLTGREQDSSRRRMELEMQVEELSAVRQTLQADLETSIRRIVDLQAALEE 1731
Human 2130 VASS-DSDTESVQTAVDCGSSGRKEMDNVSILSSQ------PEGSLQSWL--------SCTLSLA 2179
|.|| |||||||||||: ..|.::::|::|.:.|. .|| ::.|. |......
Zfish 1732 VESSDDSDTESVQTAVE-SFSRKRDLDSLSSVGSSVGTEDVGEG-IRHWAGVPRGPGSSSGRQSV 1794
Human 2180 TDTMRTPSRQSATSSRILSPRINEEAGDTERTQSALALSRARSTNVHSKTSGDKPVSPHFVRRQK 2244
||||...|.:|.|.. |...:.|.:| .|.||
Zfish 1795 TDTMSNYSFRSCTQD--LDEDVKESSG---------GLGRA------------------------ 1824
Human 2245 YCHFGDGEVLAVQRKSTERLEPASSPLASRSTNTSPLSREKLPSPSAALSEFVEGLRRKRAQRGQ 2309
|.|.||||.:||||:||....|
Zfish 1825 -------------------------------------------SSSTALSELLEGLRKKRVGWEQ 1846
Human 2310 GSTLGLEDWPTLPIYQTTGASTLRRGRAGSDEGNLSLRVGAKSPLEIEGAAGGLL--------RS 2366
||.:|.....:||||||||||.||| ||.: |||. |:..|| |....|:| |:
Zfish 1847 GSDVGEGSTVSLPIYQTTGASALRR-RASA----LSLE--AEEGLE-ELPRPGILKPPSPHLPRA 1903
Human 2367 TSLKCISSD--GVGGTTLLPEKSKTQFSSCESLLESRPSMGRKLSSPTTPRD-----MLLSPTL- 2423
:||:.:..: .|...|........:||||:| |.|..|..|::|:...|.: ...|||:
Zfish 1904 SSLRSLPEEKPAVSPATATVMGKMNRFSSCDS-LTSNTSSRRQISTLAIPEEEEESNTKPSPTIG 1967
Human 2424 -RP-RRRCLESSVDDAGCPDLGKEPLVFQNRQFAHLMEEPLGSDPFSWKLPSLDYERKTKVD-FD 2485
:| |||.|...|.::|...||.|||||||| :|.:...||....| ..
Zfish 1968 YQPVRRRLLGGLVAESGESHLGAEPLVFQNR-----------------RLLASTQERADVGDSSS 2015
Human 2486 DFLPAIRKPQTPTSLAGSAKGGQDGSQRS-SIHFETEEANRSFLSGIKTILKKSPEPKEDPAHLS 2549
|.|||||:.|:.:|||.|: .:.|.:|: |:|| |...:.:.|....: |
Zfish 2016 DILPAIRRAQSTSSLASSS--SRSGQRRALSVHF-----------GELPVSRASRRESD-----S 2062
Human 2550 DSSSSSGSIVSFKSADSIKSRPGIPRLAGDGGERTSPERREPGTGRKDDDVASIMKKYLQK 2610
|||||.|| .:..|..|||...|..| ||.|:|||||:|
Zfish 2063 DSSSSGGS----------------QKRRGPQGERLEAEGSE--------DVNSVMKKYLKK 2099
| 
