Protein Alignment SMARCA5 and ISW2

DIOPT Version :10

• Sequence 1: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Sequence 2: NP_014948.1
• Gene: ISW2 / 854480
• SGDID: S000005831
• Length: 1120
• Species: Saccharomyces cerevisiae
• Alignment Length: 1091
• Identity: 531/1091 - (48%)
• Similarity: 714/1091 - (65%)
• Gaps: 85/1091 - (7%)

Human     2 SSAAEPPPPPPPESAPSKPAASIASGGSNSSNKGGPEGVAAQAVASAASAGPADAEMEEIFDDAS 66
            :|.:|.|.....::..||     ::|.|:..|.|..|.:             :|.|:..: :|..
Yeast    14 NSKSESPSEVLVDTLDSK-----SNGSSDDDNIGQSEEL-------------SDKEIYTV-EDRP 59

Human    67 P-----GKQKEIQEPDPTY-EEKMQTDRANRFEYLLKQTELFAHFIQPAAQ--KTPTSPLKMKPG 123
            |     .|:|.:.:.||.| ::|.::|...||:|||..|:||.|||...|:  |.....||....
Yeast    60 PEYWAQRKKKFVLDVDPKYAKQKDKSDTYKRFKYLLGVTDLFRHFIGIKAKHDKNIQKLLKQLDS 124

Human   124 RPRIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFED-----SPSYVKWGKLRDY 183
            ... |..:..:.:|.....||:||:|||.||:.:..:.. |.|..||     |||:||.||||||
Yeast   125 DAN-KLSKSHSTVSSSSRHHRKTEKEEDAELMADEEEEI-VDTYQEDIFVSESPSFVKSGKLRDY 187

Human   184 QVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEF 248
            ||:||||||||:||.::|||||||||||||||||.|||:::.:.|.||.:::||||||.||..||
Yeast   188 QVQGLNWLISLHENKLSGILADEMGLGKTLQTISFLGYLRYVKQIEGPFLIIVPKSTLDNWRREF 252

Human   249 KRWVPTLRSVCLIGDKEQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRI 313
            .:|.|.:..:.|.|||:.||..||:::|...:||.:|||||:|:||:..|:..|:|:||||||||
Yeast   253 LKWTPNVNVLVLHGDKDTRADIVRNIILEARFDVLITSYEMVIREKNALKRLAWQYIVIDEAHRI 317

Human   314 KNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQ 378
            |||:|.||:|:|.|.:.||||:|||||||||||||:||||||||:|..::.||.||:.||...||
Yeast   318 KNEQSALSQIIRLFYSKNRLLITGTPLQNNLHELWALLNFLLPDIFGDSELFDEWFEQNNSEQDQ 382

Human   379 KLV-ERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSA-GKM 441
            ::| ::||.||.||||||:||||||||.||.|..:|||::.||.:||..:|.||||.:|.| ||.
Yeast   383 EIVIQQLHSVLNPFLLRRVKADVEKSLLPKIETNVYVGMTDMQIQWYKSLLEKDIDAVNGAVGKR 447

Human   442 D-KMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIF 505
            : |.|||||:|||||||||||||:|||||||||||.||:.|||||::|||||.:|||:|||||||
Yeast   448 EGKTRLLNIVMQLRKCCNHPYLFEGAEPGPPYTTDEHLIFNSGKMIILDKLLKRLKEKGSRVLIF 512

Human   506 SQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLAT 570
            |||:|:||||||||.:|::||||:||.|.|:||.::|:.||:|||.||||:|:||||||||||.|
Yeast   513 SQMSRLLDILEDYCYFRDFEYCRIDGSTSHEERIEAIDEYNKPNSEKFVFLLTTRAGGLGINLVT 577

Human   571 ADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQG 635
            ||.|||:|||||||.|||||||||||||.|.|.|:||:|:|.:||:::|||..|||||.:|||||
Yeast   578 ADTVILFDSDWNPQADLQAMDRAHRIGQKKQVHVYRFVTENAIEEKVIERAAQKLRLDQLVIQQG 642

Human   636 RLVDQNLNKIG--KDEMLQMIRHGATHVFASKESEIT-DEDIDGILERGAKKTAEMNEKLSKMGE 697
              ..:....:|  ||::|.||:.||.::|..|.|::| |.|||.||::|.:||.|:|.|...:|.
Yeast   643 --TGKKTASLGNSKDDLLDMIQFGAKNMFEKKASKVTVDADIDDILKKGEQKTQELNAKYQSLGL 705

Human   698 SSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERK---ANYAVDAYFREALRVSEPKA 759
            ..|:.|......|.|.:.|:.:::|......|||.|.:|||:   ..|:||.|::|.:......|
Yeast   706 DDLQKFNGIENQSAYEWNGKSFQKKSNDKVVEWINPSRRERRREQTTYSVDDYYKEIIGGGSKSA 770

Human   760 ------PKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGYKVP--------RNP------ 804
                  |||||.||..:.|||||||..|..|.|||.|:::|.:.|||.        ||.
Yeast   771 SKQTPQPKAPRAPKVIHGQDFQFFPKELDALQEKEQLYFKKKVNYKVTSYDITGDIRNEGSDAEE 835

Human   805 ---ELPNAAQAQ------------KEEQLKIDEAESLNDEELEEKEKLLTQGFTNWNKRDFNQFI 854
               |..|||..:            :|||.||:.|.....|:...|::|:::.|||||||||..||
Yeast   836 EEGEYKNAANTEGHKGHEELKRRIEEEQEKINSAPDFTQEDELRKQELISKAFTNWNKRDFMAFI 900

Human   855 KANEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKK 919
            .|..|:||||:|||.:.::.||||||..|:.:||||..|:...||.:..:|.||.:.::....:.
Yeast   901 NACAKYGRDDMENIKKSIDSKTPEEVEVYAKIFWERLKEINGWEKYLHNVELGEKKNEKLKFQET 965

Human   920 ALDTKIGRYKAPFHQLRISYGTNKG-KNYTEEEDRFLICMLHKLGFDKENVYDELRQCIRNSPQF 983
            .|..||.:.|.|.|:|.|.|..|.. :.|...||:||:..::|.|...:.:|::|:|.|..|..|
Yeast   966 LLRQKIEQCKHPLHELIIQYPPNNARRTYNTLEDKFLLLAVNKYGLRADKLYEKLKQEIMMSDLF 1030

Human   984 RFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEKAEKKKRGPKPSTQK 1034
            .||||:|:||..||.:|.:||:|||.||    .|:..|.||||....:|::
Yeast  1031 TFDWFIKTRTVHELSKRVHTLLTLIVRE----YEQPDANKKKRSRTSATRE 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		19/86 (22%)
		PLN03142	69..1012	CDD:215601	509/995 (51%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052		7/20 (35%)
ISW2	NP_014948.1	PLN03142	1..1093	CDD:215601	531/1091 (49%)