Protein Alignment SMARCA5 and ISW1

DIOPT Version :10

• Sequence 1: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Sequence 2: NP_009804.1
• Gene: ISW1 / 852547
• SGDID: S000000449
• Length: 1129
• Species: Saccharomyces cerevisiae
• Alignment Length: 1067
• Identity: 510/1067 - (47%)
• Similarity: 686/1067 - (64%)
• Gaps: 80/1067 - (7%)

Human    50 SAGPADAEMEEIFDDASPGKQKEIQEPDPTYEEKMQTDR-AN-----------RFEYLLKQTELF 102
            |:|......||..::..| .|..:...||...:|....: ||           |||:||..:.||
Yeast    56 SSGSIMTASEEYLENLKP-FQVGLPPHDPESNKKRYLLKDANGKKFDLEGTTKRFEHLLSLSGLF 119

Human   103 AHFIQPAAQKTPTSPLKMKPGRPRIKKDEKQNLLSVG---DYRHRRTEQEEDEELLTE--SSKAT 162
            .|||:..|.|.|.....:.     :.::.|.|....|   |.|.|:||.|||.|||.|  |....
Yeast   120 KHFIESKAAKDPKFRQVLD-----VLEENKANGKGKGKHQDVRRRKTEHEEDAELLKEEDSDDDE 179

Human   163 NVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRN 227
            ::..:|.:||:||. |:||.||::|:|||:||::|.|.|||||||||||||||||.|||:::...
Yeast   180 SIEFQFRESPAYVN-GQLRPYQIQGVNWLVSLHKNKIAGILADEMGLGKTLQTISFLGYLRYIEK 243

Human   228 IPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLPGEWDVCVTSYEMLIK 292
            ||||.:|:.|||||:||:.|..||.|.:.:..|.||||:||..::..||..::||.:.|||::|:
Yeast   244 IPGPFLVIAPKSTLNNWLREINRWTPDVNAFILQGDKEERAELIQKKLLGCDFDVVIASYEIIIR 308

Human   293 EKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPD 357
            |||..||.||.|::||||||||||:|.||:::|||.:.||||:|||||||||||||:||||||||
Yeast   309 EKSPLKKINWEYIIIDEAHRIKNEESMLSQVLREFTSRNRLLITGTPLQNNLHELWALLNFLLPD 373

Human   358 VFNSADDFDSWFDTNNCLGDQ-KLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQR 421
            :|:.|.|||.||.:.:...|| |:|::||.||:||||||||:|||.||.||||:.:|||:|.||:
Yeast   374 IFSDAQDFDDWFSSESTEEDQDKIVKQLHTVLQPFLLRRIKSDVETSLLPKKELNLYVGMSSMQK 438

Human   422 EWYTRILMKDIDILN--SAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGK 484
            :||.:||.||:|.:|  :..|..|.|||||:|||||||||||||||||||||||||.|||.|:.|
Yeast   439 KWYKKILEKDLDAVNGSNGSKESKTRLLNIMMQLRKCCNHPYLFDGAEPGPPYTTDEHLVYNAAK 503

Human   485 MVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPN 549
            :.||||||.||||:||||||||||:|:||||||||.:|||||||:||.|.|::|..:|:.||.|:
Yeast   504 LQVLDKLLKKLKEEGSRVLIFSQMSRLLDILEDYCYFRNYEYCRIDGSTAHEDRIQAIDDYNAPD 568

Human   550 STKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVE 614
            |.||||:|:||||||||||.:||||:|||||||||.|||||||||||||.|.|:|||.:|||:||
Yeast   569 SKKFVFLLTTRAGGLGINLTSADVVVLYDSDWNPQADLQAMDRAHRIGQKKQVKVFRLVTDNSVE 633

Human   615 ERIVERAEMKLRLDSIVIQQGRL-VDQNLNKI-GKDEMLQMIRHGATHVFASKES---------- 667
            |:|:|||..|||||.:||||.|. :.:..||. .||.:|.||:|||..||.|..|
Yeast   634 EKILERATQKLRLDQLVIQQNRTSLKKKENKADSKDALLSMIQHGAADVFKSGTSTGSAGTPEPG 698

Human   668 ---EITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREK--QKIAF 727
               :..|.|:|.:|.:...||..:|.|...:|...|:.|..|   |.|.:.|:|:::|  :.|..
Yeast   699 SGEKGDDIDLDELLLKSENKTKSLNAKYETLGLDDLQKFNQD---SAYEWNGQDFKKKIQRDIIS 760

Human   728 TEWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFY 792
            ...:.|.|||||.||::|.|:::.|.......|..||.||.......|..||:|..|.|||.::.
Yeast   761 PLLLNPTKRERKENYSIDNYYKDVLNTGRSSTPSHPRMPKPHVFHSHQLQPPQLKVLYEKERMWT 825

Human   793 RKTIGYKVPRNPELPNA--------AQAQKEEQLK--IDEAESLNDEELEEKEKLLTQGFTNWNK 847
            .|..|| ||...::..|        .:.||.|.||  ::.::.|.:||.:.|....::|||||||
Yeast   826 AKKTGY-VPTMDDVKAAYGDISDEEEKKQKLELLKLSVNNSQPLTEEEEKMKADWESEGFTNWNK 889

Human   848 RDFNQFIKANEKWGRDDIENIAREV-EGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARI 911
            .:|.:||..:.|:||:.|:.||||: .|||.|||..|:..||.....::|.||.:..||..|.:|
Yeast   890 LEFRKFITVSGKYGRNSIQAIARELAPGKTLEEVRAYAKAFWSNIERIEDYEKYLKIIENEEEKI 954

Human   912 QRRISIKKALDTKIGRYKAPFHQLRISY--GTNKGKNYTEEEDRFLICMLHKLGFDKENVYDELR 974
            :|....::||..|:..||.||..|::.:  .:|..:.|:||||||::.||.|.|.|:::||:.:|
Yeast   955 KRVKMQQEALRRKLSEYKNPFFDLKLKHPPSSNNKRTYSEEEDRFILLMLFKYGLDRDDVYELVR 1019

Human   975 QCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERE---NMELEEKEKAEKKKR---------- 1026
            ..||:.|.|..|::.:|||.:||.||.|||:..:|:|   .:.|::..|...||.
Yeast  1020 DEIRDCPLFELDFYFRSRTPVELARRGNTLLQCLEKEFNAGIVLDDATKDRMKKEDENGKRIREE 1084

Human  1027 -GPKPSTQKRKMDGAPDGRGRKKKLKL 1052
             ..:.:.:|..:||.     ..||.|:
Yeast  1085 FADQTANEKENVDGV-----ESKKAKI 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		8/32 (25%)
		PLN03142	69..1012	CDD:215601	495/995 (50%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052		9/47 (19%)
ISW1	NP_009804.1	PLN03142	108..1057	CDD:215601	488/958 (51%)