DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCA5 and Mi-2

DIOPT Version :9

Sequence 1:NP_003592.3 Gene:SMARCA5 / 8467 HGNCID:11101 Length:1052 Species:Homo sapiens
Sequence 2:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster


Alignment Length:1114 Identity:325/1114 - (29%)
Similarity:493/1114 - (44%) Gaps:256/1114 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    69 KQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHFIQPAAQKTPTSPLKMKPGRPRIKKDEKQ 133
            |.:|:.....|:||:     .:..:.|.:..:.:.........:|..|..|      :.||..|.
  Fly   634 KWRELPYDKSTWEEE-----GDDIQGLRQAIDYYQDLRAVCTSETTQSRSK------KSKKGRKS 687

Human   134 NLLSVGDYRHRRTEQEEDEELL----TESSKATNVCTRFEDSPSYVKWG--KLRDYQVRGLNWLI 192
            .|         :.|.:||..:.    ......|::..::||.|::::..  :|..||:.|:|||.
  Fly   688 KL---------KVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLR 743

Human   193 SLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRS 257
            ..:..||:.|||||||||||:||::.|..:....:..||.:|.||.|||.||..||:.|.|....
  Fly   744 YSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYC 808

Human   258 VCLIGDKEQRAAFVRDVLLPGE------------------WDVCVTSYEMLIKEKSVFKKFNWRY 304
            :..||||:.||. :|:..|..|                  ::|.:||||::..:.:.....:|..
  Fly   809 ITYIGDKDSRAV-IRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAV 872

Human   305 LVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWF 369
            ||:|||||:|:.:||...|:..:....:||||||||||||.||:.|||||..|.||....|...|
  Fly   873 LVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEF 937

Human   370 DTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDI 434
            ..   :..::.|:|||.:|.|.:|||:|.||.|::|.|.|..:.|.||.||:::|..||.|:.:.
  Fly   938 AD---VSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEA 999

Human   435 LNSAGKMDKMRLLNILMQLRKCCNHPYLFDGA------EPGPPYTTDMHLVTNSGKMVVLDKLLP 493
            |||........|:||:|.|:|||||||||..|      ..|..|..: .|...:||:|:|.|:|.
  Fly  1000 LNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEIN-SLTKAAGKLVLLSKMLK 1063

Human   494 KLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLS 558
            :||.|..|||||||||::||||||:.....|:|.|:||......||::|:.:|.|.:.:|||:||
  Fly  1064 QLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLS 1128

Human   559 TRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEM 623
            ||||||||||||||.||:|||||||..|:||..|||||||...|.::||:|.|:||||:.:.|:.
  Fly  1129 TRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKR 1193

Human   624 KLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESE----ITDEDIDGILERG--- 681
            |:.|..:|::.| :..:..| ..|.|:..::|.|...:|...:.|    ..|:.:..:|:|.   
  Fly  1194 KMMLTHLVVRPG-MGGKGAN-FTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRG 1256

Human   682 -AKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERKANYAVD 745
             .:|.:..||.||....:|            |..:.|:..|:.:|.          ::.|..:..
  Fly  1257 IEEKESWANEYLSSFKVAS------------YATKEEEEEEETEII----------KQDAENSDP 1299

Human   746 AYFREALRVSEPK--------APKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGYKVPR 802
            ||:.:.||....:        ..|..|..||.|..|                   ...:.....|
  Fly  1300 AYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTD-------------------GGVVAADTTR 1345

Human   803 N--------PELPNAAQAQKEEQLKIDEAESLNDEELEEKEKLLTQ------------------- 840
            :        .|..:...|..:|....|:.:..|..|.:.|.:|..:                   
  Fly  1346 DDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVL 1410

Human   841 GFTNWNKRDFNQFIKA------------NEKW---------------------------GRDDIE 866
            ||   |.|....|:.|            |.:|                           |.|:.|
  Fly  1411 GF---NARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAE 1472

Human   867 NIAREV--EGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDTKIGRYK 929
            ..|..|  ||.:.:.|:....|......::|:.|.|.......|..::....::.||...:...:
  Fly  1473 TFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALE 1537

Human   930 APFHQLRISYGTNKGKNYT--------------------EEEDRFLICMLHKLGFDKENVYDELR 974
            ||      ..|.|..|:.|                    :.||:           ||::..:   
  Fly  1538 AP------PTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDK-----------DKDSEKE--- 1582

Human   975 QCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEKAEKKKRGP--------KPS 1031
                           |.:|:.|...        :::|....|:|:..:.|:..|        |||
  Fly  1583 ---------------KDKTSAEKSE--------VKQEQEAEEDKKPGDVKQENPVEEAAGDTKPS 1624

Human  1032 TQKRKMDGA 1040
            ..:.|.:.|
  Fly  1625 DAEVKTEVA 1633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCA5NP_003592.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..83 4/13 (31%)
PLN03142 69..1012 CDD:215601 315/1076 (29%)
DEAH box 308..311 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1052 9/34 (26%)
Mi-2NP_001014591.1 CHDNT 138..190 CDD:285335
PHD1_CHD_II 380..422 CDD:277006
PHD2_CHD_II 440..482 CDD:277007
CHROMO 490..558 CDD:237991
CHROMO 615..667 CDD:214605 6/37 (16%)
SNF2_N 734..1028 CDD:278600 126/297 (42%)
DEXDc 751..907 CDD:238005 59/156 (38%)
Helicase_C 1053..1167 CDD:278689 69/113 (61%)
DUF1087 <1292..1337 CDD:283996 11/63 (17%)
DUF1086 1380..1517 CDD:283992 23/139 (17%)
CHDCT2 1756..1927 CDD:285336
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
21.870

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