Protein Alignment SMARCA5 and brm

DIOPT Version :9

• Sequence 1: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Sequence 2: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Alignment Length: 1058
• Identity: 320/1058 - (30%)
• Similarity: 494/1058 - (46%)
• Gaps: 226/1058 - (21%)

Human    54 ADAEMEEIFDDASPGKQKE---IQEPDPTYEEKMQTDRANRFEYLLKQTELF------------- 102
            |:||.|:..:.....|::.   :.|.:..|.:.:...:..|..:||.||:.:
  Fly   550 ANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKD 614

Human   103 ---------------------------------------AHFIQPAAQKTPTSP----------- 117
                                                   .|.::....|..|..
  Fly   615 DQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRW 679

Human   118 LKMKPGRPRIKKDEKQNLLSVGDYRHRRTEQE----------------------------EDEEL 154
            |.|.||...| .||:.:..|..|::.:..||.                            ||:|.
  Fly   680 LNMHPGWDWI-DDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEY 743

Human   155 LTES----SKATNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQT 215
            .||.    |.|..:..:..:..|.:..|.|::||::||.||:|||.|.:|||||||||||||:||
  Fly   744 RTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQT 808

Human   216 ISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLPGEW 280
            |||:.|:...:.:.||::::||.|||.||:.||::|.|.:..|...|..:.| ..:::.:...::
  Fly   809 ISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGR-RLLQNQMRATKF 872

Human   281 DVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVR-EFKTTNRLLLTGTPLQNNL 344
            :|.:|:||.:||:|:|..|..|:|::|||.||:||...||::::. .:....|||||||||||.|
  Fly   873 NVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKL 937

Human   345 HELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQK----------LVERLHMVLRPFLLRRIKAD 399
            .|||:|||||||.:|.|...|:.||:.......:|          ::.|||.|||||||||:|.:
  Fly   938 PELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKE 1002

Human   400 VEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSA-----GKMDKMRLLNILMQLRKCCNH 459
            ||..||.|.|..|...:|.:||..|..:..|.:.:.:.:     ||.....|:|.::||||.|||
  Fly  1003 VEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNH 1067

Human   460 PYLFD-------------GAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRV 511
            |::|.             |...||    |::.|  |||..:||::|||||....|||:|.|||:.
  Fly  1068 PFMFQHIEEKYCDHTGGHGVVSGP----DLYRV--SGKFELLDRILPKLKATNHRVLLFCQMTQC 1126

Human   512 LDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVVIL 576
            :.|:|||..||.:.|.||||.|..::|.:.:..:|...|..|||:|||||||||:||.|||.|::
  Fly  1127 MTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVI 1191

Human   577 YDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQN 641
            :||||||..||||.||||||||...|||.|.:|.|:|||||:..|..||.:|..|||.| :.||.
  Fly  1192 FDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAG-MFDQK 1255

Human   642 LNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERGAKKTAEMNEKLSK------------ 694
            .....:.:.||.|.|...:. ..:|:|:.|:::..::...:::..|:.:::..
  Fly  1256 STGSERQQFLQTILHQDDNE-EEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPG 1319

Human   695 ----MGESSLRNFTMDTESSVYNFE---------GEDYREKQKIAFT------EWIEPPKRERKA 740
                :.||.|.::....:..|..|.         |...|:::::.:|      ||::
  Fly  1320 RERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLK-------- 1376

Human   741 NYAVD--AYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGYKVPRN 803
              |:|  |.|.|.....:.|..:..|..::....|            :..||..|:.
  Fly  1377 --AIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDD------------DSLILKRRRR-------- 1419

Human   804 PELPNAAQAQKEEQLKIDEAESLNDEELEEKEKLLTQGFTNWNKR----DFNQFIKANEKWGRDD 864
               .|..:..|::..||..|...::::    .:.|::.|.....|    |:.:.||...     |
  Fly  1420 ---QNLDKRSKKQMHKIMSAVIKHNQD----GRTLSEPFMKLPSRQRLPDYYEIIKRPV-----D 1472

Human   865 IENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARI--QRRISIKKALDTKIGR 927
            |:.|.:.:|.....::.|....|.:.|..        |||...||.:  ...|:::|.......|
  Fly  1473 IKKILQRIEDCKYADLNELEKDFMQLCQN--------AQIYNEEASLIYLDSIALQKVFVGARQR 1529

Human   928 YKAPFHQLRISYGTNKGK 945
            ..|......::.|.|.|:
  Fly  1530 ITAAADAAAVAAGDNTGE 1547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		7/31 (23%)
		PLN03142	69..1012	CDD:215601	316/1043 (30%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903
		HSA	501..573	CDD:214727	5/22 (23%)
		BRK	649..693	CDD:197800	9/44 (20%)
		PHA02934	687..>824	CDD:165245	46/137 (34%)
		SNF2_N	776..1071	CDD:278600	130/295 (44%)
		DEXDc	793..932	CDD:238005	61/139 (44%)
		Helicase_C	1097..1212	CDD:278689	65/114 (57%)
		SnAC	1304..1375	CDD:291293	9/70 (13%)
		Bromo_SNF2L2	1425..1530	CDD:99947	24/121 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910