Protein Alignment SMARCA5 and CG7376

DIOPT Version :10

• Sequence 1: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Sequence 2: NP_648034.1
• Gene: CG7376 / 38715
• FlyBaseID: FBgn0035689
• Length: 1270
• Species: Drosophila melanogaster
• Alignment Length: 1288
• Identity: 230/1288 - (17%)
• Similarity: 420/1288 - (32%)
• Gaps: 497/1288 - (38%)

Human    60 EIFDDASP-----------GKQK--------EIQEPDPTYEEKMQTDRANRFEY----------L 95
            ||.|:..|           ||::        |.:|......||.|..|..:.::          :
  Fly     8 EIADEVPPESPEDPTEFRYGKKRWVFKDNLVEHKEEILICIEKCQNARTRKLKFRSIRQESGSCI 72

Human    96 L----KQTELFAHFIQPAAQKTPTSPLKMKPGRP----RIKKDEKQNLLSVGDY----------- 141
            |    :||.:.|..|:....: ...||..|..|.    .:.:.||::...:..|
  Fly    73 LVLSHEQTHVRAREIEMEVGE-QVLPLFFKDFRGSLEFEVAQQEKEHKRPLKTYVTTKLYDALYE 136

Human   142 RHRRTEQEEDEELLTESSKATNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYE---------- 196
            :||:|...|.|       ::.::..||:        .:||.||.|.::|::...:
  Fly   137 KHRQTVHVEQE-------RSLDLPKRFQ--------SQLRKYQQRTVSWMLGREQQITQVPANFI 186

Human   197 -----NGI--------------------------NGILADEMGLGKTLQTISLL--------GYM 222
                 :||                          .||||||||||||::.:::|        .|.
  Fly   187 VLHAIDGITRVFKHKYCLQFYPFEEEIPKISLPPGGILADEMGLGKTVEFLAMLLMNPRPQDSYR 251

Human   223 KHY--------------------------------------------------------RNIP-- 229
            ..|                                                        .::|
  Fly   252 NDYWHQRLEEFSDEVPLKRSRISKKDEVFCICTKKHGKRVQCTKCRRWQHEMCMTISEKSDLPHL 316

Human   230 ------------------GPHMVLVPKSTLHNWMSEFKRWV-PTLRSVCLIGDKEQRAAFVRDVL 275
                              |..:::.|.:....|..|..:.: |:|:.:...|   ..:.|.....
  Fly   317 CPSCWSELVKSGERLVESGATIIVSPNAIKMQWFEEIHKHISPSLKVLLYFG---LHSTFWVSPF 378

Human   276 LPGEWDVCVTSYEML----------------------IKEKSVFKKFNWRYLVIDEAHRIKNEKS 318
            ...::||.:|.|.:|                      ::..|.....||..:.:|||..:::..|
  Fly   379 DLAQYDVVLTDYTILRNEIYHTTDFKSDRQMRHQQRYMRPNSPLLMVNWWRVCLDEAQMVESSTS 443

Human   319 KLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFL-LPDVFNSADDF---DSWFDTN-NCLGDQ 378
            ..:|:||.....||..:|||     :.||..||.|: .|:|....|.:   |..|..| .|
  Fly   444 AAAEMVRMLPAINRWAVTGT-----IDELPPLLEFVGRPEVCRPPDAWQTVDKAFQLNYKC---- 499

Human   379 KLVERLHMVLRPFLLRRIKADVEKSL--PPKKEVKIYVGLSKMQREWY----------------- 424
               |.|..:|...|.|..|:.||..|  ||:.||...:.||.::..:|
  Fly   500 ---EPLLELLEHSLWRTCKSKVEHELGIPPQTEVVHRLELSNVESLYYREEHLKCHEQFLAAVAK 561

Human   425 -TRILMKDIDILNSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVL 488
             ||....:...|.|........:|...:::|:.|:.|.:|:.......|   :|          .
  Fly   562 HTRHNADNSSCLASISPQLLRIILKPFLRIRQTCSVPVVFNSNVSSTDY---LH----------P 613

Human   489 DKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNE------ 547
            ..||.:||.                        .|...|:.:.:|       ..::||.
  Fly   614 QDLLARLKS------------------------NNENECKTELRT-------WASSYNGLAAIYF 647

Human   548 -----PNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRA----------HRIG 597
                 |.:.|:..:|...|........:.|.|:...:.:|.   |||...|          |:..
  Fly   648 IKNDFPQAIKYYNLLLKLANEYNEQNISVDSVLQIHAIYNL---LQASSLAPAEHKLTELEHKKY 709

Human   598 QTKTVRV-FRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHV 661
            |.:..|: ::::.|||   |::|.|     |.|        .::||.|:.:.|
  Fly   710 QAQMSRLEWKYLEDNT---RVLESA-----LSS--------YNENLEKVSELE------------ 746

Human   662 FASKESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIA 726
               |..|.:..|:...:         :|.|.|             ...:::|...:|:
  Fly   747 ---KRFEGSTLDLLATM---------VNHKTS-------------LHDAIWNKVRDDF------- 779

Human   727 FTEWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFE-------- 783
            |.:.|...:.|...:.|...||.:   :...|....    |...:.:|:|....:.:
  Fly   780 FRQNISVERLENVNSMAGMLYFMD---IWHNKLQNL----KSTLIAEFEFLKGVMQQACEAIKTG 837

Human   784 -LLEKEILFYRKTIGYKVPRNPELPNAAQAQKEEQLKIDE---------AESLND-------EEL 831
             ||..||:.:.:.:..     ..|.:...|.|::.:|..:         .:|||.       ::|
  Fly   838 VLLSMEIINFIENVTV-----CHLTDILDANKDKPVKPKKHRYCRLCLIRDSLNQFECLLFAKKL 897

Human   832 EEKEKLLTQGFTNWNKRDFNQFIKANEKW--GRDDIENIAREVEGKTP-----EEVIEYSAVFWE 889
            :|| ..:|:|..|.:..  ..|||:...:  .:.|......|.:.|..     ::::::...:|
  Fly   898 DEK-ATVTEGLENPSME--ISFIKSIFAFLRSKQDFSEWKEECQSKLELLSCLQDLVKFQIKYW- 958

Human   890 RCNELQDIEKIMAQIERGEARI-----------QRRISIKKALDTKIGRYKAPFHQL-------R 936
              .|::.:.|...::|..:.||           .|.::.:.....:..:|.....||       |
  Fly   959 --IEVEYMVKAFDELEMCKMRILLTDDPEEQSNYRILACQLDEQLQFNQYNLQTSQLNFTRLCGR 1021

Human   937 ISYGTNKGKN---------YTEEEDRFLICML-HKLGFDKENVYDELRQ------------CIRN 979
            :.|..:..::         .|:::.|:::.:. |   |..::..|.:|:            |.::
  Fly  1022 LKYLKHLKEDSADKPCPICQTQDDVRYVMMVCGH---FVCQHCLDSMRRKNGRAGVTKCPLCRQD 1083

Human   980 SPQFRF------------DWFLKSRTAMELQRRCNTLITLIERENMELEEKEK 1020
            |||..:            |:..|..:.:|       |:..|:.||    |:||
  Fly  1084 SPQLYYSVRPGAHKSIIGDFSTKISSVVE-------LVLKIKGEN----EQEK 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		8/41 (20%)
		PLN03142	69..1012	CDD:215601	220/1258 (17%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052		3/6 (50%)
CG7376	NP_648034.1	DEXQc_SHPRH	160..513	CDD:350828	68/367 (19%)
		PHD_SF	281..320	CDD:473978	1/38 (3%)
		TPR	636..669	CDD:197478	6/32 (19%)
		RING_Ubox	1036..1082	CDD:473075	7/48 (15%)
		SF2_C_SNF	1104..1225	CDD:350180	9/33 (27%)