Protein Alignment SMARCA5 and hrp3

DIOPT Version :10

• Sequence 1: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Sequence 2: NP_001342861.1
• Gene: hrp3 / 2543064
• PomBaseID: SPAC3G6.01
• Length: 1388
• Species: Schizosaccharomyces pombe
• Alignment Length: 1084
• Identity: 341/1084 - (31%)
• Similarity: 526/1084 - (48%)
• Gaps: 205/1084 - (18%)

Human    71 KEIQEPDPT-------------------YEEKMQTDRA--------NRFEYLLKQTELFAHF--- 105
            :||:| |||                   |||..|.||.        ...|||:|..:|...|
pombe   257 REIRE-DPTTTREDIEAMDIEKERKRENYEEYKQVDRIVAKHLNSDGSVEYLVKWKQLLYDFCTW 320

Human   106 -----IQPAAQKTPTSPLKMKPGRPRIKKDEKQNLLSVGDYRHRRTE----QEEDEELLTESSKA 161
                 |:|.|                                  .||    ||.:|..|: .|:.
pombe   321 EASSIIEPIA----------------------------------ATEIQAFQEREESALS-PSRG 350

Human   162 TNV------CTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLG 220
            ||.      ..:.|..|||:..|:|||:|:.|:||:..|:....|||||||||||||:||::.|.
pombe   351 TNYGNSRPKYRKLEQQPSYITGGELRDFQLTGVNWMAYLWHKNENGILADEMGLGKTVQTVAFLS 415

Human   221 YMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRD--VLLPG----E 279
            |:.|.....||.:|:||.||:..|......|...:..:..:|:...|.. :||  ..:.|    :
pombe   416 YLAHSLRQHGPFLVVVPLSTVPAWQETLALWASDMNCISYLGNTTSRQV-IRDYEFYVDGTQKIK 479

Human   280 WDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNL 344
            :::.:|:||.::|::||.....|:|:.||||||:||.:|.|.|.:.:||.:||||:||||||||:
pombe   480 FNLLLTTYEYVLKDRSVLSNIKWQYMAIDEAHRLKNSESSLYEALSQFKNSNRLLITGTPLQNNI 544

Human   345 HELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKE 409
            .||.:|::||:|..|...::.:.......   .:..:..|...|:|::|||:|.|||||||.|.|
pombe   545 RELAALVDFLMPGKFEIREEINLEAPDEE---QEAYIRSLQEHLQPYILRRLKKDVEKSLPSKSE 606

Human   410 VKIYVGLSKMQREWYTRILMKDIDIL-NSAGKMDKMRLLNILMQLRKCCNHPYLFDGAE------ 467
            ..:.|.||.:|..||..||.::..:| .|.....::.||||:::|:|..||||||||.|
pombe   607 RILRVELSDLQMYWYKNILTRNYRVLTQSISSGSQISLLNIVVELKKASNHPYLFDGVEESWMQK 671

Human   468 ---PGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRL 529
               .|........|:.||||||:|||||.:|:..|.||||||||.|:||||.||...|.|.:.||
pombe   672 INSQGRRDEVLKGLIMNSGKMVLLDKLLSRLRRDGHRVLIFSQMVRMLDILGDYLSLRGYPHQRL 736

Human   530 DGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAH 594
            ||..|...|:.||:.:|.|||..|||:||||||||||||.|||.||::|||||||.|||||.|||
pombe   737 DGTVPAAVRRTSIDHFNAPNSPDFVFLLSTRAGGLGINLMTADTVIIFDSDWNPQADLQAMARAH 801

Human   595 RIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLN----KIGKDEMLQMIR 655
            ||||...|.|:|.::.:|:||.::|||..|:.|:..:|..| :.|:..|    |...:|:..:::
pombe   802 RIGQKNHVMVYRLLSKDTIEEDVLERARRKMILEYAIISLG-VTDKQKNSKNDKFSAEELSAILK 865

Human   656 HGATHVFASK--ESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGED 718
            .||:::|.::  :.::.|.::|.|||.     ||.::..:.:|.:|     |..|..:..||..|
pombe   866 FGASNMFKAENNQKKLEDMNLDEILEH-----AEDHDTSNDVGGAS-----MGGEEFLKQFEVTD 920

Human   719 YREKQKIAFTEWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFE 783
            |  |..:::.:.|...:||:         |.|..|:.|.:                        |
pombe   921 Y--KADVSWDDIIPLTEREK---------FEEEDRLREEE------------------------E 950

Human   784 LLEKEILFYRKTIGYKVP----RNPELPNAAQAQKEEQLKIDEAESLNDEELEEKE-KLLTQGFT 843
            .|::||....:......|    .:|.....::.:.::|:       |.||.|.||| :||.:...
pombe   951 ALKQEIELSSRRGNRPYPSSAVESPSYSGTSERKSKKQM-------LKDEVLLEKEIRLLYRAMI 1008

Human   844 NWNKRD--FNQFIKANEKWGRDD--IENIAREVEGKTPEEVIEYSAVFWERCNEL---QDIEKIM 901
            .:...:  :|..:|..:...:|.  |:.||.::...:.:.|   ||...:..|:.   :...|.:
pombe  1009 RYGSLEHRYNDIVKYADLTTQDAHVIKKIAADLVTASRKAV---SAAEKDLSNDQSNNKSSRKAL 1070

Human   902 AQIERGEARIQRRISIKKALDTKI----------GRYKAPFHQLRISYGTNKGKNYTEEEDRFLI 956
            ....:|...|.....:::..|..|          ..::.|.| :|..:|.:  ..:...||..|:
pombe  1071 LITFKGVKNINAETLVQRLNDLDILYDAMPTSGYSNFQIPMH-VRSVHGWS--CQWGPREDSMLL 1132

Human   957 CMLHKLGFD-------------KENVY-DELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITL 1007
            ..:.|.||.             |:.:: ::.:|...:.|:.:.:...|..:|:.|.||...|::.
pombe  1133 SGICKHGFGAWLEIRDDPELKMKDKIFLEDTKQTDNSVPKDKENKEKKVPSAVHLVRRGEYLLSA 1197

Human  1008 IERENMELEEKEK---AEKKKRGPKPSTQKRKMDGAPDGRGRKK 1048
            :...:.....|..   :...|..||..|..|:..|.|:.:..:|
pombe  1198 LREHHQNFGIKSSPAISTNGKTQPKKQTANRRQSGKPNVKSAQK 1241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		8/30 (27%)
		PLN03142	69..1012	CDD:215601	332/1043 (32%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052		9/37 (24%)
hrp3	NP_001342861.1	CD1_tandem_CHD1_yeast_like	189..250	CDD:349312
		CD2_tandem	286..339	CDD:349306	15/86 (17%)
		PLN03142	339..>895	CDD:215601	241/566 (43%)
		Cdh1_DBD_1	997..1081	CDD:408024	17/86 (20%)
		DUF4208	1300..1384	CDD:464035