Protein Alignment SMARCA5 and snf21

DIOPT Version :10

• Sequence 1: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Sequence 2: NP_594861.1
• Gene: snf21 / 2542638
• PomBaseID: SPAC1250.01
• Length: 1199
• Species: Schizosaccharomyces pombe
• Alignment Length: 1041
• Identity: 342/1041 - (32%)
• Similarity: 502/1041 - (48%)
• Gaps: 197/1041 - (18%)

Human    42 AQAVASAASAGPADAEMEEIFDDASPGKQK--EIQEPD-PTYEEKMQTDRANRFEYLLKQTELFA 103
            ||....|..|..:..|.||........||:  .::|.| ..|.:.:...:..|..:||:||:
pombe   293 AQKANRAVLAYHSHIEKEEQRRAERNAKQRLQALKENDEEAYLKLIDQAKDTRITHLLRQTD--- 354

Human   104 HFIQPAAQKTPTSPLKMKPGRPRIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRF 168
            |::...|              ..:|..:.|...|..|....|....||:..:...:.|.|:....
pombe   355 HYLDSLA--------------AAVKVQQSQFGESAYDEDMDRRMNPEDDRKIDYYNVAHNIREVV 405

Human   169 EDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHM 233
            .:.||.:..|||::||:|||.|:||||.|.:|||||||||||||:|||||:.::...:...||.:
pombe   406 TEQPSILVGGKLKEYQLRGLQWMISLYNNHLNGILADEMGLGKTIQTISLITHLIEKKRQNGPFL 470

Human   234 VLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLP----GEWDVCVTSYEMLIKEK 294
            |:||.|||.||..||:||.|::..:...|..:     ||..|.|    ..:.|.:|:||.:||::
pombe   471 VIVPLSTLTNWTMEFERWAPSIVKIVYKGPPQ-----VRKALHPQVRHSNFQVLLTTYEYIIKDR 530

Human   295 SVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTN-RLLLTGTPLQNNLHELWSLLNFLLPDV 358
            .:..:..|.|::|||.||:||.:|||:..:..:.::. ||:||||||||||.|||:||||:||.:
pombe   531 PLLSRIKWIYMIIDEGHRMKNTQSKLTNTLTTYYSSRYRLILTGTPLQNNLPELWALLNFVLPRI 595

Human   359 FNSADDFDSWFDT--NNCLGDQKL----------VERLHMVLRPFLLRRIKADVEKSLPPKKEVK 411
            |||...||.||:|  .|..|..|:          :.|||.|||||||||:|.|||..||.|.|..
pombe   596 FNSIKSFDEWFNTPFANTGGQDKMELTEEESLLVIRRLHKVLRPFLLRRLKKDVEAELPDKVEKV 660

Human   412 IYVGLSKMQREWYTRILMKDIDILNSA--GKMDKMRLLNILMQLRKCCNHPYLFDGAEPG---PP 471
            |...:|.:|::.|.::....:..:..|  ||.....|.|.:|||:|.||||::|:..|..   ..
pombe   661 IRCQMSGLQQKLYYQMKKHGMLYVEDAKRGKTGIKGLQNTVMQLKKICNHPFVFEDVERSIDPTG 725

Human   472 YTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHD 536
            :..|| |...|||..:||::||||...|.|:|:|.|||::::|:|||..:|.:.|.||||.|..|
pombe   726 FNYDM-LWRVSGKFELLDRILPKLFRSGHRILMFFQMTQIMNIMEDYLHYRQWRYLRLDGSTKAD 789

Human   537 ERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKT 601
            :|...:..:|:|.:...:|:|||||||||:||.|||.||::||||||..||||.||||||||||.
pombe   790 DRSKLLGVFNDPTAEVNLFLLSTRAGGLGLNLQTADTVIIFDSDWNPHQDLQAQDRAHRIGQTKE 854

Human   602 VRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKE 666
            ||::|.||:.:|||.|:.||:.||.:|..|||.|:..    ||...:|....:|       :..|
pombe   855 VRIYRLITEKSVEENILARAQYKLDIDGKVIQAGKFD----NKSTPEEREAFLR-------SLLE 908

Human   667 SEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWI 731
            :|..:|:.|   |:|.....|:||.|:: |:..||.|...||.
pombe   909 NENGEEEND---EKGELDDDELNEILAR-GDDELRLFKQMTED---------------------- 947

Human   732 EPPKRERKANYAVDAYFREALRVSE-PKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKT 795
                .||::.|..:......::||| |:..:...|.|..             :||::|
pombe   948 ----LERESPYGKNKEKERLIQVSELPEFYQREEPEKTT-------------DLLQEE------- 988

Human   796 IGYKVPRNPELPNAAQAQKEEQLKIDEAESLND----EELE-EKEKLLTQGFTNWN--KRDFNQF 853
                       |....|::...:..|||  :.|    .|:: |.|...|:|....|  ..|....
pombe   989 -----------PLGRGARRRTPVVYDEA--VRDAQWMAEMDMESEARPTRGRPKRNIASVDETPA 1040

Human   854 IKANEKWGRDDIENIAREVEGKTPEEVI-EYSAVFWERC-------NELQD-----IEKIMAQIE 905
            :..|.|         .::..|..|:.:. |:.::....|       |||:|     :.|:..::.
pombe  1041 LTLNGK---------PKKKRGPAPDTLTSEHRSLLRRVCLEIYKAVNELEDDNGRPLNKLFLELP 1096

Human   906 RGEARIQRRISIKK--ALDTKIGRYKAPFHQ----LRISYGT--NKGKNYTEEEDRFLICMLHKL 962
            ..:......:.||.  |||.........|::    ::....|  |..:.|.||
pombe  1097 SKKLYPDYYMIIKSPIALDAIRKHINGTFYKTLEAMKSDLMTMFNNARTYNEE------------ 1149

Human   963 GFDKENVYDELRQCIRNSPQFRFDWFLKSRTAMELQ----RRCNTLITLIERENMELEEKEKAEK 1023
               ...||::..               |.:||||.:    ....||.||   ..||.|...:.|.
pombe  1150 ---GSFVYEDAN---------------KMQTAMETKIEELEEDGTLATL---RGMEAEATSQLED 1193

Human  1024 K 1024
            :
pombe  1194 R 1194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		12/43 (28%)
		PLN03142	69..1012	CDD:215601	331/1000 (33%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052		2/10 (20%)
snf21	NP_594861.1	HSA	256..328	CDD:214727	9/34 (26%)
		PLN03142	305..>947	CDD:215601	275/679 (41%)
		SnAC	949..1012	CDD:464219	18/95 (19%)
		Bromo_SNF2	1066..1168	CDD:99950	24/131 (18%)