Protein Alignment SMARCA5 and hrp1

DIOPT Version :10

• Sequence 1: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Sequence 2: NP_593660.1
• Gene: hrp1 / 2542363
• PomBaseID: SPAC1783.05
• Length: 1373
• Species: Schizosaccharomyces pombe
• Alignment Length: 1226
• Identity: 376/1226 - (30%)
• Similarity: 563/1226 - (45%)
• Gaps: 289/1226 - (23%)

Human    11 PPPESAPSKPA----ASIASGGSNSSNK------GGPEGVAAQAVASAASAGPADAEMEEIFDDA 65
            |.|:...||||    .|:||...::.:|      ....|...:....::.....:...:|.:||.
pombe   126 PIPKKRKSKPAPKQKKSVASDDEDAYDKRHRFSINSASGTEIRTSLRSSKGKSVNYNEQEFYDDF 190

Human    66 SPGKQKEIQEPDPTYE-------------EKMQTDRANRFEYLLKQTELFAHFIQPAAQKTPTSP 117
            ...:::..::.:..||             :....|..:.::||:|..|: :|........:..|.
pombe   191 EDEEEEVEEQVEEEYEPIIDFVLNHRKRADAQDDDPKSSYQYLIKWQEV-SHLHNTWEDYSTLSS 254

Human   118 LKMKPGRPRIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNV------------------ 164
            ::   |..::....|||::...:.|...|...||.|.|....:..|:
pombe   255 VR---GYKKVDNYIKQNIIYDREIREDPTTTFEDIEALDIERERKNMLFEEYKIVERIVASETNE 316

Human   165 -----------------CT-----------------------------------------RFEDS 171
                             ||                                         :.|..
pombe   317 EGKTEYFVKWRQLPYDNCTWEDADVIYSMAPNEVYQFLQRENSPYLPYKGVFYNTRPPYRKLEKQ 381

Human   172 PSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLV 236
            |||:|.|::||:|:.|:||:..|:....|||||||||||||:||:..|.|:.|.....||.:::|
pombe   382 PSYIKGGEIRDFQLTGINWMAYLWHRNENGILADEMGLGKTVQTVCFLSYLVHSLKQHGPFLIVV 446

Human   237 PKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLL-------PGEWDVCVTSYEMLIKEK 294
            |.||:..|......|.|.|.|:|..|:.|.||. :|:...       ..::::.:|:||.::|:|
pombe   447 PLSTVPAWQETLANWTPDLNSICYTGNTESRAN-IREYEFYLSTNSRKLKFNILLTTYEYILKDK 510

Human   295 SVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVF 359
            .......|:||.||||||:||.:|.|.|.:.:|:|.||||:|||||||||.||.||:|||:|..|
pombe   511 QELNNIRWQYLAIDEAHRLKNSESSLYETLSQFRTANRLLITGTPLQNNLKELASLVNFLMPGKF 575

Human   360 NSADDFDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWY 424
            ...|:.:  ||..|. ..::.:..|...|:||:|||:|.|||||||.|.|..:.|.||.||.|||
pombe   576 YIRDELN--FDQPNA-EQERDIRDLQERLQPFILRRLKKDVEKSLPSKSERILRVELSDMQTEWY 637

Human   425 TRILMKDIDILNSAGKMD---KMRLLNILMQLRKCCNHPYLFDGAEP----GPPYT---TDMHLV 479
            ..||.|:...|  .|..|   ::.||||:::|:|..||||||.||..    |...|   |...::
pombe   638 KNILTKNYRAL--TGHTDGRGQLSLLNIVVELKKVSNHPYLFPGAAEKWMMGRKMTREDTLRGII 700

Human   480 TNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINA 544
            .||||||:|||||.:||..|.||||||||.|:|:||.:|...|.|.|.||||..|...|:.||:.
pombe   701 MNSGKMVLLDKLLQRLKHDGHRVLIFSQMVRMLNILGEYMSLRGYNYQRLDGTIPASVRRVSIDH 765

Human   545 YNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFIT 609
            :|.|:|..|||:||||||||||||.|||.||::|||||||.|||||.|||||||...|.|:||::
pombe   766 FNAPDSPDFVFLLSTRAGGLGINLNTADTVIIFDSDWNPQADLQAMARAHRIGQKNHVNVYRFLS 830

Human   610 DNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLN----KIGKDEMLQMIRHGATHVFASKESE-- 668
            .:||||.|:|||..|:.|:..:|..| :.:::.|    |....|:..:::.||:::|.:.|::
pombe   831 KDTVEEDILERARRKMILEYAIISLG-VTEKSKNSKNDKYDAQELSAILKFGASNMFKATENQKK 894

Human   669 ITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEP 733
            :.:.::|.||..     ||..:..:.:|.:|     |..|..:..||..||:.:.    ..|.:
pombe   895 LENMNLDDILSH-----AEDRDSSNDVGGAS-----MGGEEFLKQFEVTDYKAED----LNWDD- 944

Human   734 PKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGY 798
                                                      ..|....|.:|:|
pombe   945 ------------------------------------------IIPEEEMERIEEE---------- 957

Human   799 KVPRNPELPNAAQ-AQKEEQLKIDEAESLNDEELEEKE-KLLTQGFTNWNKR--------DFNQF 853
                  |...||| |::||:.:.:|.|..|||:...:. |..|:..|...:|        :....
pombe   958 ------ERMLAAQRAKEEERERREEEERENDEDHPSRTYKRTTKSITKRQQRREEMVREKEIRLL 1016

Human   854 IKANEKWGRDD--IENIAREVE--GKTPEEVIEYSAVFWERCNELQDIEKIMAQ----------- 903
            .:|..|:|..|  .:.|.:|.|  ...|:.:...||...:.|:|.  :|::.|.
pombe  1017 YRAMIKFGLVDERFDTIVKEAELQATDPKRIYSLSADMVKACDEA--VERLGADDTKNKQPRKAI 1079

Human   904 -IE-RGEARIQRR---ISIK---------KALDTK---IGRYKAPFHQLRISYGTNKGKNYTEEE 951
             || :|...|...   :.:|         |.||..   ||......|....|:|.        :|
pombe  1080 LIEFKGVKNINAETVTLRVKDLTHLHRAYKGLDPLKQIIGYPIRSVHSWNCSWGI--------KE 1136

Human   952 DRFLICMLHKLGFDKENVYDELRQCIRNSPQFRF--DWFL-------KSR---TAMELQRRCNTL 1004
            |..|:..::|.||.       ..|.|:|.|....  ..||       :||   :|:.|.||...|
pombe  1137 DSMLLAGINKHGFG-------CWQAIKNDPDLGLHDKIFLDEAKNDKESRYVPSAVHLVRRGEYL 1194

Human  1005 ITLIERENMEL-----EEKEKAEKKKRGP-KPSTQKRKMDGA-----PDGRGRKKK 1049
            :::: ||:.:|     ::..|.:..::.| |.||::..:||:     ...|.:|||
pombe  1195 LSVV-REHPDLFVVKTDQPTKRKYNRKAPTKSSTRQTTLDGSISNTKKSSRTKKKK 1249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		16/94 (17%)
		PLN03142	69..1012	CDD:215601	349/1108 (31%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052		12/46 (26%)
hrp1	NP_593660.1	CD1_tandem_CHD1_yeast_like	207..266	CDD:349312	8/62 (13%)
		CD2_tandem	302..355	CDD:349306	2/52 (4%)
		PLN03142	377..>909	CDD:215601	250/543 (46%)
		Cdh1_DBD_1	1010..1090	CDD:408024	17/81 (21%)
		CHDCT2	1132..>1159	CDD:462358	10/41 (24%)