Protein Alignment SMARCA5 and isw-1

DIOPT Version :10

• Sequence 1: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Sequence 2: NP_001379931.1
• Gene: isw-1 / 175944
• WormBaseID: WBGene00002169
• Length: 1009
• Species: Caenorhabditis elegans
• Alignment Length: 995
• Identity: 631/995 - (63%)
• Similarity: 776/995 - (77%)
• Gaps: 37/995 - (3%)

Human    77 DPTYE---EKMQTDRAN---RFEYLLKQTELFAHFIQPAAQKTPT-SPLKMKP-GRPRIKKDEKQ 133
            ||:.|   |...:|.|:   |||.||::||.|:|.:.....|..| :|:..|. |||     .|:
 Worm    28 DPSMEVDDEPESSDAADSFKRFERLLQKTENFSHCLSSGDAKLATGAPVDTKKRGRP-----SKK 87

Human   134 NLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENG 198
            |.:. ||:|||:||||||||::.::.|:.::.. |:.||.|::.|::|||||||||||.||..|.
 Worm    88 NGID-GDHRHRKTEQEEDEEMVADAIKSDDLVI-FDKSPFYIENGEMRDYQVRGLNWLASLQHNK 150

Human   199 INGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGD 263
            |||||||||||||||||||::||||||:|...||:|:||||||.||.:|||:|.|::.:|.||||
 Worm   151 INGILADEMGLGKTLQTISMIGYMKHYKNKASPHLVIVPKSTLQNWANEFKKWCPSINAVVLIGD 215

Human   264 KEQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFK 328
            :..|...:|||:||.::|||.|:|||::|.|:..||.||||::||||||||||||||||.|||..
 Worm   216 EAARNQVLRDVILPQKFDVCCTTYEMMLKVKTQLKKLNWRYIIIDEAHRIKNEKSKLSETVRELN 280

Human   329 TTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQKLVERLHMVLRPFLL 393
            :.||||:|||||||||||||:||||||||:|.|:|||||||..:...|:..||:|||.||:||||
 Worm   281 SENRLLITGTPLQNNLHELWALLNFLLPDIFTSSDDFDSWFSNDAMSGNTDLVQRLHKVLQPFLL 345

Human   394 RRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLLNILMQLRKCCN 458
            ||||:||||||.||||||:|||||||||||||::|||||||:|.|||::|.||:||||.||||.|
 Worm   346 RRIKSDVEKSLLPKKEVKVYVGLSKMQREWYTKVLMKDIDIINGAGKVEKARLMNILMHLRKCVN 410

Human   459 HPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRN 523
            |||||||||||||:|||.|||.||||||||||||.|.||||||||||||.:|:||:|||:|.||:
 Worm   411 HPYLFDGAEPGPPFTTDQHLVDNSGKMVVLDKLLMKFKEQGSRVLIFSQFSRMLDLLEDFCWWRH 475

Human   524 YEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQ 588
            ||||||||.|||::|.::|.|||.|:|.||:|||:|||||||||||||||||:||||||||.|||
 Worm   476 YEYCRLDGSTPHEDRSNAIEAYNAPDSKKFIFMLTTRAGGLGINLATADVVIIYDSDWNPQSDLQ 540

Human   589 AMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLNKIGKDEMLQM 653
            ||||||||||.|.|||||.||:|||:|||:|:||.|||||:|||||||:.:.. ..:||.:|:.|
 Worm   541 AMDRAHRIGQKKQVRVFRLITENTVDERIIEKAEAKLRLDNIVIQQGRMSEAQ-KTLGKGDMISM 604

Human   654 IRHGATHVFASKESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTES--SVYNFEG 716
            |||||..|||:|:|.|:|:|||.|||:...||||:|||:.|:.|::|||.|.:..:  :||.|||
 Worm   605 IRHGAEQVFAAKDSTISDDDIDTILEKAEVKTAELNEKMGKIDENNLRNMTFEDNAKFTVYQFEG 669

Human   717 EDYREKQKIAFTE-WIEPPKRERKANYAVDAYFREALRVSEP--KAPKAPRPPKQPNVQDFQFFP 778
            |:|:.||...... |||||||||||||.||.|::||:|...|  |..|||| ||.|.|.||||:|
 Worm   670 ENYKAKQADGMGHFWIEPPKRERKANYQVDLYYKEAMRAGNPTEKQSKAPR-PKLPQVFDFQFYP 733

Human   779 PRLFELLEKEILFYRKTIGYKVPRNPELP--NAAQAQKEEQLKIDEAESLNDEELEEKEKLLTQG 841
            .||||||:|||..|||||||...|..::|  .|.:.|.|||..|:.|..|.|:|.|||.:||||.
 Worm   734 RRLFELLDKEIYHYRKTIGYVAERPKDVPPKEAEKRQAEEQKLINNARPLTDKEQEEKAELLTQS 798

Human   842 FTNWNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIER 906
            .|:|.||:|.||::.|||:||:|:|:||:|:| :..||:..|:.|||||..||||.||:::|||:
 Worm   799 VTDWTKREFQQFVRGNEKYGREDLESIAKEME-RPLEEIQSYAKVFWERIEELQDSEKVLSQIEK 862

Human   907 GEARIQRRISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLHKLGFDKENVYD 971
            |||||||:.::|||||.||.:|||||.||||||||||||.|||||||||:|..|:||.|||||::
 Worm   863 GEARIQRKYAVKKALDAKIAKYKAPFQQLRISYGTNKGKTYTEEEDRFLVCETHRLGHDKENVFE 927

Human   972 ELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKE-----KAEKKKRGPKPS 1031
            ||||.:|.:|||||||||||||||||||||||||||||||..|:.|.:     .|:|||...|..
 Worm   928 ELRQSVRMAPQFRFDWFLKSRTAMELQRRCNTLITLIEREMGEVVESKPVIVTAADKKKSVAKDL 992

Human  1032 TQKRKMDGAPDGRGRKKKLK 1051
            :   |..|.|..    ||:|
 Worm   993 S---KSSGTPTA----KKVK 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		3/8 (38%)
		PLN03142	69..1012	CDD:215601	617/949 (65%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052		12/42 (29%)
isw-1	NP_001379931.1	PLN03142	48..1008	CDD:215601	625/975 (64%)