Protein Alignment USP32 and Usp2

DIOPT Version :10

• Sequence 1: XP_011523673.1
• Gene: USP32 / 84669
• HGNCID: 19143
• Length: 1634
• Species: Homo sapiens
• Sequence 2: NP_001285528.1
• Gene: Usp2 / 33132
• FlyBaseID: FBgn0031187
• Length: 950
• Species: Drosophila melanogaster
• Alignment Length: 854
• Identity: 149/854 - (17%)
• Similarity: 204/854 - (23%)
• Gaps: 521/854 - (61%)

Human   747 ANSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKG 811
            |:||:.::     .:|..||.|:||||||||.|||:|:||.||: |:...|......|....:..
  Fly   613 ASSSRDEK-----SEGLCGLRNIGNTCFMNSVIQCLSHTQELTR-FLRSHHGSRSLSTKDQQILH 671

Human   812 HMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHE 876
            ..||    |:||:|:.....|.|::|:...:.....::.:.|||:||.|.|.||.||..||...:
  Fly   672 EFAK----LIQEMWTANVHTVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSALNSGVK 732

Human   877 KPYVELKD--SDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFL 939
            ...:.:.|  ||.:.    |...|:.:.|...|:|.|||.|||:|.:||.|||:.||.||||..|
  Fly   733 GETLNIDDNLSDNKK----ADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDL 793

Human   940 SLPLPMDSYMHLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLSDLCGLNSEQILLAEVHGSNI 1004
            |:|||..|
  Fly   794 SVPLPSSS--------------------------------------------------------- 801

Human  1005 KNFPQDNQKVRLSVSGFLCAFEIPVPVSPISASSPTQTDFSSSPSTNEMFTLTTNGDLPRPIFIP 1069
                                                                             
  Fly   802 ----------------------------------------------------------------- 801

Human  1070 NGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMRTELYFLSSQKNRPSLFGMP 1134
                                                                             
  Fly   802 ----------------------------------------------------------------- 801

Human  1135 LIVPCTVHTRKKDLYDAVWIQVSRLASPLPPQEASNHAQDCDDSMGYQYPFTLRVVQKDGNSCAW 1199
                                                                             
  Fly   802 ----------------------------------------------------------------- 801

Human  1200 CPWYRFCRGCKIDCGEDRAFIGNAYIAVDWDPTALHLRYQTSQERVVDEHESVEQSRRAQAEPIN 1264
                    .||
  Fly   802 --------RCK------------------------------------------------------ 804

Human  1265 LDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIV 1329
            |::||..|..||.|..:||..|:||||....||...:.|.|..|:||||||.  ..||.|...||
  Fly   805 LEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFS--ETRWSKLSNIV 867

Human  1330 KFPRESFDPSAFLVPRDPALCQHKPLTPQGDELSEPRILAREVKKVDAQSSAGEEDVLLSKSPSS 1394
            :||..                                         |::.:.|           |
  Fly   868 EFPTS-----------------------------------------DSELNMG-----------S 880

Human  1395 LSANIISSPKGSPSSSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKLSSSKENLDA 1459
            ..||                                                      |..|:.
  Fly   881 YGAN------------------------------------------------------SNSNVH- 890

Human  1460 SKENGAGQICELADALSRGHVLGGSQPELVTPQDHEVALANGFLYEHEACGNGYSNGQLGNHSEE 1524
                                                                             
  Fly   891 ----------------------------------------------------------------- 890

Human  1525 DSTDDQREDTRIKPIYNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKE-LHPDEIDTD 1587
                           |:|||||.|.|...|||||...|:| :.||:.:||:...: |..:.:.:.
  Fly   891 ---------------YSLYAISNHMGSTAGGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSS 940

Human  1588 SAYILFYEQ 1596
            ||||||||:
  Fly   941 SAYILFYER 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
USP32	XP_011523673.1	EFh	253..309	CDD:238008
		EF-hand_7	286..358	CDD:463900
		UBP12	534..1346	CDD:227847	114/600 (19%)
		UCH	<1261..1594	CDD:425685	64/334 (19%)
Usp2	NP_001285528.1	UBP12	<620..>800	CDD:227847	76/193 (39%)
		Peptidase_C19R	626..948	CDD:239139	143/833 (17%)