Protein Alignment HYCC1 and Hyccin

DIOPT Version :10

• Sequence 1: NP_115970.2
• Gene: HYCC1 / 84668
• HGNCID: 24587
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_611256.1
• Gene: Hyccin / 37019
• FlyBaseID: FBgn0034269
• Length: 544
• Species: Drosophila melanogaster
• Alignment Length: 552
• Identity: 154/552 - (27%)
• Similarity: 262/552 - (47%)
• Gaps: 74/552 - (13%)

Human     8 VVEEWLSEFKTL------PETSLPNYATNLKDKSSLVSSLYKVIQEPQ--SELLEPVCHQLFEFY 64
            :|.:||::::.:      .|..:..:.|:    ..:..:::.:..|.|  ..|:..:|.||..||
  Fly     4 LVRDWLADYQRIRGQPSEAEAFVVEHETD----PEIAEAIFTIFNERQRNETLVHDICQQLLAFY 64

Human    65 RSGEEQLLQFTLQFLPELIWCYLAVSASRNVHSSGCIEALLLGVYNLEIVDKQGHTKVLSFTIPS 129
            ||.|:.|.:|.|||:|.|::.||...|..:..::..:|.||:.:||.|:..:.|..||::|.:|.
  Fly    65 RSPEQTLHKFPLQFIPVLLYTYLHSVAGGDKKAARGVETLLICIYNGEVSTEDGGQKVVAFRMPI 129

Human   130 LSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTY 194
            |::.|||||   :.::.:|:....:...::.|..|||.:.|.:.||||..:||.||.|||..::.
  Fly   130 LAQTSVYHE---VKNLPMTDLRRWEENCNREVKWGPHQRIESIHAQNRMRILTALLFCYNQQVSQ 191

Human   195 MPSVSLQSLCQICSRICVCGYPRQ----HVRKY-----------KGISSRIPVSSGFMVQMLTGI 244
            ....||..||::.|::...|:..:    |...|           |..|.|||:|:.|:::::..|
  Fly   192 TQKSSLLHLCRVTSQLVNQGFTTKSGHGHRMSYGSDPATGVPFPKPSSPRIPLSAAFLIELVHAI 256

Human   245 YFAFYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGPMKSNKEGTRCIQVEITPT- 308
            |||.:||...:|.:.||||..||..|:|.|.:||.:|::.||...|.....:|...:.|.:||:
  Fly   257 YFAMFNGFGTIAIQTLDDIHNRAIYEMYSEVILVTSAVRNSLHANPSGQPNDGPMGLSVALTPST 321

Human   309 ---SSRISRNAVTSMSIRGHRWKRHGN------TELTGQ---EELMEISEVDEGFYSRAASSTSQ 361
               ::.:|::.:|:.|.   |.|:..:      .:||.|   ::|..::|..|.....:.|:...
  Fly   322 TTVTTSVSKSMITNASF---RTKKLPDDIPIQVQDLTIQQAPQQLASVTEETEPGTKESPSTKES 383

Human   362 SGLSNSSHNCSNKPSIGKNHRR--SGGSKTGGKEKETTGESCKDHFARKQTQRAQSENLELLSLK 424
            ||...|....|.:....:.|:.  :|..|:..||||      ||....|..||...::.:..||.
  Fly   384 SGTRTSIMRPSMEGIKAQAHKALIAGFKKSKDKEKE------KDKEPPKPPQRKFDKHTQRNSLL 442

Human   425 RLTLTTSQSLPKPSSHGLAKTAATVFSKSFEQVSGVTVPHNPSSAVGCGAGTDANRFSACSLQEE 489
            :|.       .:|||:..|:...|          |..:|....|.:.   ...:|.||..|...:
  Fly   443 QLQ-------AEPSSNSSAEQPPT----------GEVLPLQTLSLIN---ENGSNSFSVDSDLND 487

Human   490 KLIYVSERTELPMKHQSGQQRPPSISITLSTD 521
            .::.||..|.||....:......|..||.|.|
  Fly   488 GVLGVSANTSLPPLSSTTNSVTSSDLITKSFD 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HYCC1	NP_115970.2	Hyccin	22..330	CDD:462903	102/328 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..413		16/59 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..521		5/19 (26%)
Hyccin	NP_611256.1	Hyccin	20..346	CDD:462903	103/335 (31%)