Protein Alignment GLIS2 and ci

DIOPT Version :10

• Sequence 1: NP_115964.2
• Gene: GLIS2 / 84662
• HGNCID: 29450
• Length: 524
• Species: Homo sapiens
• Sequence 2: NP_524617.3
• Gene: ci / 43767
• FlyBaseID: FBgn0004859
• Length: 1397
• Species: Drosophila melanogaster
• Alignment Length: 335
• Identity: 118/335 - (35%)
• Similarity: 167/335 - (49%)
• Gaps: 56/335 - (16%)

Human    27 TLGVVRPRALHRELG----LVDDSPTPGSPGS--PPSGFLLNSKFPEKVEGRFSAAPLVDLSLSP 85
            |...:|...:|..|.    .:..|||.....|  |.:.|.|.:    ..:.|....|..|:....
  Fly   310 TSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKN----LDDAREKKGPFKDVVPEQ 370

Human    86 PSG-------LDSPNGSSSLSPERQGNGDLPPVPSASDFQPLRYLDGVPSSFQFFLPLG---SGG 140
            ||.       :::.:.||.||.....|             .:..:.|:|...:....|.   :.|
  Fly   371 PSSTSGGVAQVEADSASSQLSDRCYNN-------------VVNNITGIPGDVKVNSRLDEYINCG 422

Human   141 ALHLPASSF------LTPPKDKCLSPDLPLPKQLV---CRWAKCNQLFELLQDLVDHVNDYHVKP 196
            ::.:|::.:      .|..||:        |...:   |.|..|...|....:||.|:|:.|::.
  Fly   423 SISIPSNEYDCANADTTDIKDE--------PGDFIETNCHWRSCRIEFITQDELVKHINNDHIQT 479

Human   197 EKDAGYCCHWEGCARHGRGFNARYKMLIHIRTHTNEKPHRC--PTCSKSFSRLENLKIHNRSHTG 259
            .|.| :.|.||.|.|..:.|.|:|.:::|:|.||.||||:|  ..|.|::|||||||.|.|||||
  Fly   480 NKKA-FVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTG 543

Human   260 EKPYVCPYEGCNKRYSNSSDRFKH-TRTHYVDKPYYCKMPGCHKRYTDPSSLRKHIK-AHG-HFV 321
            ||||.|.|.||:|.:||:|||.|| .|||..:|||.||.|||.||||||||||||:| .|| .|.
  Fly   544 EKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFY 608

Human   322 SHEQQELLQL 331
            ::::.:.|.|
  Fly   609 ANKKHKGLPL 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLIS2	NP_115964.2	Interaction with CTNND1. /evidence=ECO:0000250	35..174		30/163 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..62		7/28 (25%)
		Transcription activation. /evidence=ECO:0000250	71..137		12/72 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..114		7/36 (19%)
		Transcription repression. /evidence=ECO:0000250	148..171		4/31 (13%)
		C2H2 Zn finger	213..229	CDD:275368	5/15 (33%)
		COG5048	233..>327	CDD:227381	62/98 (63%)
		C2H2 Zn finger	237..257	CDD:275368	12/21 (57%)
		C2H2 Zn finger	265..287	CDD:275368	13/22 (59%)
		C2H2 Zn finger	295..317	CDD:275368	18/22 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..480
ci	NP_524617.3	zf-H2C2_2	503..>521	CDD:463886	9/17 (53%)
		SFP1	<513..603	CDD:227516	60/89 (67%)
		C2H2 Zn finger	519..541	CDD:275368	12/21 (57%)
		zf-H2C2_2	533..560	CDD:463886	18/26 (69%)
		C2H2 Zn finger	549..572	CDD:275368	13/22 (59%)
		C2H2 Zn finger	580..601	CDD:275368	17/20 (85%)