Protein Alignment GLYR1 and Jasper

DIOPT Version :10

• Sequence 1: NP_115958.2
• Gene: GLYR1 / 84656
• HGNCID: 24434
• Length: 553
• Species: Homo sapiens
• Sequence 2: NP_651768.1
• Gene: Jasper / 43576
• FlyBaseID: FBgn0039743
• Length: 475
• Species: Drosophila melanogaster
• Alignment Length: 231
• Identity: 64/231 - (27%)
• Similarity: 96/231 - (41%)
• Gaps: 46/231 - (19%)

Human     2 AAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAH 66
            ||.|..:||||:.|:..|||||.||.       |....|.:.|.|:||.:.|.||:|.|.||.::
  Fly     6 AAASYSIGDLVFAKVKGYPPWPAKIT-------KSNNNKKYNVYFYGTGETANIKLEDLFPYASN 63

Human    67 KEEMI--KINKGKRFQQAVDAVEEFLR--------RAKGKDQTSSHNSSDDKNRRNSSEERSRPN 121
            ||...  ||.|..:|.:|:|.:|..||        ...|.:..:...:.|     ....|..:|.
  Fly    64 KERFATEKIMKRAKFIEAIDQIESALRGEDSAPIDLLDGAEPVAPPTTGD-----GVKTEEPKPE 123

Human   122 SGDEKRKLSLSEGKVKKNMGEGKKRVSS------GSSERGSKSPLKRAQEQSPRKRGRPPKDEKD 180
            .|.|....:......:|....|.::..:      |.||.|::.              .||..::.
  Fly   124 PGPEPATAAPVAAAAEKPKKSGTRKTKAPPRHVDGDSEAGAEL--------------APPPAKRR 174

Human   181 LTIPESSTVKGMMAGPMAAFKWQPTAS-EPVKDADP 215
            :.....:|...:.|.|.||   .||:| :.||.:.|
  Fly   175 VPTEGLATAAAIPAAPAAA---TPTSSKKSVKKSKP 207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLYR1	NP_115958.2	PWWP_GLYR1	6..90	CDD:438961	34/85 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	92..188		14/101 (14%)
		DUF4603	110..>173	CDD:464684	10/68 (15%)
		Rossmann-fold NAD(P)(+)-binding proteins	<210..>302	CDD:473865	3/6 (50%)
		Interaction with histone H3. /evidence=ECO:0000269|PubMed:23260659	214..217		1/2 (50%)
		Interaction with KDM1B. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	216..225		64/231 (28%)
		Dehydrogenase domain. /evidence=ECO:0000305|PubMed:30970244	261..553
		MmsB	268..551	CDD:441687
Jasper	NP_651768.1	PWWP_HRP	10..86	CDD:438959	33/82 (40%)
		LEDGF	320..440	CDD:463284