DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF2B and kif2c

DIOPT Version :9

Sequence 1:	NP_115948.4	Gene:	KIF2B / 84643	HGNCID:	29443	Length:	673	Species:	Homo sapiens
Sequence 2:	NP_001006856.1	Gene:	kif2c / 448620	XenbaseID:	XB-GENE-961445	Length:	734	Species:	Xenopus tropicalis

Alignment Length:	734	Identity:	312/734 - (42%)
Similarity:	436/734 - (59%)	Gaps:	115/734 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    29 GIYVAIQRSDKRIHLAVVTEINRENYWVTVEWVEKAVKKGKKIDLETILLLNP-ALDSAEHP--- 89
            |:.|.|.||:..||.|.:|.:|.:...|.|||.|....|||:|....::.:|| .||:...|
Frog    12 GLVVKIMRSNGVIHNASITSVNMDRSSVNVEWKEGDANKGKEISFADVISVNPELLDAVLAPPNV 76

Human    90 ---MPPPPLSPL---------------------ALAP----SSAIRDQRTATKWV---------- 116
               |||....|.                     :|.|    .|.:|::.|....:
Frog    77 KENMPPQRNVPSQNQKRKTISKIPAPKEVTTQNSLLPEYGAQSVLRERSTRMTAIHEALPSENEM 141

Human   117 ----AMIP-QKNQTASGDSLDVR------VPSKPCLMK--------------QKKSPCLWEIQKL 156
                .::| |:|....|.|...:      :.|:|.:.:              ::||..:.|::|:
Frog   142 EVESTVLPVQQNSIQVGRSRSTKASVAGELRSQPRISEIVEESLPPVRNNQARRKSNIVKEMEKM 206

Human   157 QEQREKRRRLQQEIRARRALDVNTRNPNYEIMHMIEEYRRHLDSSKISVLEPPQEHRICVCVRKR 221
            :.:||::|....|:|.:||.|.:|..||:|...||:::|..:|..:||:.:|.:|||||||||||
Frog   207 KNKREEQRAQNSELRIKRAQDYDTSIPNWEFGKMIKDFRATMDCHRISMADPAEEHRICVCVRKR 271

Human   222 PLNQRETTLKDLDIITVPSDNVVMVHESKQKVDLTRYLQNQTFCFDHAFDDKASNELVYQFTAQP 286
            |||::|.:.|::|||:|||.|:|:|||.|.|||||:||:||.|.||::||:.|:||:||:|||:|
Frog   272 PLNKQELSKKEIDIISVPSKNIVLVHEPKLKVDLTKYLENQPFRFDYSFDETATNEVVYRFTARP 336

Human   287 LVESIFRKGMATCFAYGQTGSGKTYTMGGDFSGTAQDCSKGIYALVAQDVFLLLRNSTYEKLDLK 351
            ||:|||..|.||||||||||||||:||||||||.:|:.|||:||..::||||||....|:.|||.
Frog   337 LVQSIFEGGKATCFAYGQTGSGKTHTMGGDFSGKSQNVSKGVYAFASRDVFLLLDQPRYKHLDLD 401

Human   352 VYGTFFEIYGGKVYDLLNWKKKLQVLEDGNQQIQVVGLQEKEVCCVEEVLNLVEIGNSCRTSRQT 416
            |:.||||||.|||:||||.|.||:||||..|::|||||.|::|...::|..::|:|::||||.||
Frog   402 VFVTFFEIYNGKVFDLLNKKAKLRVLEDAKQEVQVVGLLERQVTSADDVFKMIEVGSACRTSGQT 466

Human   417 PVNAHSSRSHAVFQIILKSGRIMHGKFSLVDLAGNERGADTTKASRKRQLEGAEINKSLLALKEC 481
            ..|:.||||||..||||:.|..:||||||||||||||||||..|.|..::||||||:||||||||
Frog   467 FANSSSSRSHACLQIILRRGSKLHGKFSLVDLAGNERGADTASADRITRMEGAEINRSLLALKEC 531

Human   482 ILALGQNKPHTPFRASKLTLVLRDSFIGQNSSTCMIATISPGMTSCENTLNTLRYANRVKKLN-- 544
            |.||||||.|||||.||||.:|||||||:||.|||||.:|||..|||.||||||||:|||:|:
Frog   532 IRALGQNKSHTPFRESKLTQILRDSFIGENSRTCMIAMLSPGFNSCEYTLNTLRYADRVKELSPQ 596

Human   545 ----------VDVRPYHRGHYPIG------------HEAPRMLKSHIGNSEMSLQRDEFIKIPYV 587
                      ::.......|..||            .|    |.:||.:.:.:|.|        |
Frog   597 NAETNDDNLQMETEDSDGSHASIGGLQLQDDFLLKDEE----LSTHINSFQDALNR--------V 649

Human   588 QSEEQKEIEEVETLPTLLGKDTTISGKGSSQWLENIQERAGGVHHDIDFCIARSLSILEQKIDAL 652
            ...|:|.:||:..|.           :...:| .|:.:......:|::..:.::..:::::...|
Frog   650 GELEEKAVEELRELV-----------QREPEW-TNLLQTTEQPDYDLENFVIQAEYLIQERSKVL 702

Human   653 TEIQKKLKLLLADLHVKSK 671
            ..:...:..|...|.|:.:
Frog   703 ISLGDSINSLRLALQVEEQ 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF2B	NP_115948.4	KISc_KIF2_like	213..541	CDD:276818	222/327 (68%)
KIF2B	NP_115948.4	Kinesin	219..541	CDD:278646	216/321 (67%)
kif2c	NP_001006856.1	KISc_KIF2_like	263..591	CDD:276818	222/327 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D108002at7742
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010