Protein Alignment KIF2B and kif2a

DIOPT Version :10

• Sequence 1: NP_115948.4
• Gene: KIF2B / 84643
• HGNCID: 29443
• Length: 673
• Species: Homo sapiens
• Sequence 2: XP_002934245.2
• Gene: kif2a / 100379688
• XenbaseID: XB-GENE-951755
• Length: 745
• Species: Xenopus tropicalis
• Alignment Length: 736
• Identity: 385/736 - (52%)
• Similarity: 488/736 - (66%)
• Gaps: 105/736 - (14%)

Human    23 FGDIQEGIYVAIQRSDKRIHLAVVTEINRENYWVTVEWVEKAVKKGKKIDLETILLLNPALDSAE 87
            ||.|..||||.|:|||.|||.|:||.:|.::..:||||:|....|||:||||:|..|||.|...|
 Frog     5 FGKIHIGIYVEIKRSDGRIHQAMVTSLNEDSESITVEWIENGDTKGKEIDLESIFSLNPDLAPDE 69

Human    88 H-----PMPPPPLSPLALAPSSAIRDQRTATKWVAMIPQKNQTASGDSLDVRV------PSKPCL 141
            .     .|||||.....:  :..::::||      :.|.||:|.:.|:....|      ||:|..
 Frog    70 EIDPGPEMPPPPTPTTKV--NKIVKNRRT------VAPVKNETPARDNRVAAVSSARARPSQPIE 126

Human   142 M--------------------------KQKKSPCLWEIQKLQEQREKRRRLQQEIRARRALDVNT 180
            .                          .::||.|:.|::||||:|||||..|||:|.::|.||:.
 Frog   127 QSASAQQNGSVSDISPDQPGKKDFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKKAQDVDA 191

Human   181 RNPNYEIMHMIEEYRRHLDSSKISVLEPPQEHRICVCVRKRPLNQRETTLKDLDIITVPSDNVVM 245
            .|||||||.||:::|..||...::..:...||||||||||||||::|.|:||||:||:||.:|||
 Frog   192 TNPNYEIMCMIKDFRGSLDYRPLTTADTIDEHRICVCVRKRPLNKKENTVKDLDVITIPSKDVVM 256

Human   246 VHESKQKVDLTRYLQNQTFCFDHAFDDKASNELVYQFTAQPLVESIFRKGMATCFAYGQTGSGKT 310
            |||.||||||||:|:||||.||:|||:.|.||:||:|||:||||:||.:||||||||||||||||
 Frog   257 VHEPKQKVDLTRFLENQTFRFDYAFDETAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKT 321

Human   311 YTMGGDFSGTAQDCSKGIYALVAQDVFLLLRNSTYEKLDLKVYGTFFEIYGGKVYDLLNWKKKLQ 375
            :||||||||..||||||||||.|:|||.:|:...|:||:|:||.||||||.|||:||||.|.||:
 Frog   322 HTMGGDFSGKNQDCSKGIYALAARDVFQMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLR 386

Human   376 VLEDGNQQIQVVGLQEKEVCCVEEVLNLVEIGNSCRTSRQTPVNAHSSRSHAVFQIILKSGRIMH 440
            |||||.||:|||||||:||.|||:||.|:|||||||||.||..|||||||||||||||:....:|
 Frog   387 VLEDGKQQVQVVGLQEREVKCVEDVLKLIEIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLH 451

Human   441 GKFSLVDLAGNERGADTTKASRKRQLEGAEINKSLLALKECILALGQNKPHTPFRASKLTLVLRD 505
            |||||:|||||||||||:.|.|:.:|||||||||||||||||.|||:|||||||||||||.||||
 Frog   452 GKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRD 516

Human   506 SFIGQNSSTCMIATISPGMTSCENTLNTLRYANRVKKLNV---DVRPYHRG-----------HY- 555
            ||||:||.|||||||||||.||||||||||||||||:..:   |: |:.:|           .|
 Frog   517 SFIGENSRTCMIATISPGMASCENTLNTLRYANRVKEFGISPSDI-PFSQGSGSRSDLSPSYEYD 580

Human   556 -----------------------PIGHEAPRMLKS-----HIGNSEMSLQRDEFIKIPYVQSEEQ 592
                                   |:.|.||..|..     .:|:|.   |||: :|:...|:||:
 Frog   581 DFSPTLTRVKELTVDPSAAGDLRPMIHHAPNQLDDVEALWGVGSSP---QRDD-LKLLCEQNEEE 641

Human   593 ---------KEIEEVETLPTLLGKDTTISGKGSSQWLEN---IQERAGGVHHDIDFCIARSLSIL 645
                     :.:.::..:...:.:|.....:.|.:|||:   :.|....|.:|:|....:..:||
 Frog   642 VSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWLEDEKVLLEMTEEVDYDVDSYATQLEAIL 706

Human   646 EQKIDALTEIQKKLKLLLADL 666
            |||||.|||::.|:|...|.|
 Frog   707 EQKIDILTELRDKVKSFRAAL 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF2B	NP_115948.4	KISc_KIF2_like	213..541	CDD:276818	256/327 (78%)
kif2a	XP_002934245.2	KISc_KIF2_like	224..552	CDD:276818	256/327 (78%)