DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF2B and kif2a

DIOPT Version :9

Sequence 1:	NP_115948.4	Gene:	KIF2B / 84643	HGNCID:	29443	Length:	673	Species:	Homo sapiens
Sequence 2:	XP_002934245.2	Gene:	kif2a / 100379688	XenbaseID:	XB-GENE-951755	Length:	745	Species:	Xenopus tropicalis

Alignment Length:	736	Identity:	385/736 - (52%)
Similarity:	488/736 - (66%)	Gaps:	105/736 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    23 FGDIQEGIYVAIQRSDKRIHLAVVTEINRENYWVTVEWVEKAVKKGKKIDLETILLLNPALDSAE 87
            ||.|..||||.|:|||.|||.|:||.:|.::..:||||:|....|||:||||:|..|||.|...|
Frog     5 FGKIHIGIYVEIKRSDGRIHQAMVTSLNEDSESITVEWIENGDTKGKEIDLESIFSLNPDLAPDE 69

Human    88 H-----PMPPPPLSPLALAPSSAIRDQRTATKWVAMIPQKNQTASGDSLDVRV------PSKPCL 141
            .     .|||||.....:  :..::::||      :.|.||:|.:.|:....|      ||:|..
Frog    70 EIDPGPEMPPPPTPTTKV--NKIVKNRRT------VAPVKNETPARDNRVAAVSSARARPSQPIE 126

Human   142 M--------------------------KQKKSPCLWEIQKLQEQREKRRRLQQEIRARRALDVNT 180
            .                          .::||.|:.|::||||:|||||..|||:|.::|.||:.
Frog   127 QSASAQQNGSVSDISPDQPGKKDFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKKAQDVDA 191

Human   181 RNPNYEIMHMIEEYRRHLDSSKISVLEPPQEHRICVCVRKRPLNQRETTLKDLDIITVPSDNVVM 245
            .|||||||.||:::|..||...::..:...||||||||||||||::|.|:||||:||:||.:|||
Frog   192 TNPNYEIMCMIKDFRGSLDYRPLTTADTIDEHRICVCVRKRPLNKKENTVKDLDVITIPSKDVVM 256

Human   246 VHESKQKVDLTRYLQNQTFCFDHAFDDKASNELVYQFTAQPLVESIFRKGMATCFAYGQTGSGKT 310
            |||.||||||||:|:||||.||:|||:.|.||:||:|||:||||:||.:||||||||||||||||
Frog   257 VHEPKQKVDLTRFLENQTFRFDYAFDETAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKT 321

Human   311 YTMGGDFSGTAQDCSKGIYALVAQDVFLLLRNSTYEKLDLKVYGTFFEIYGGKVYDLLNWKKKLQ 375
            :||||||||..||||||||||.|:|||.:|:...|:||:|:||.||||||.|||:||||.|.||:
Frog   322 HTMGGDFSGKNQDCSKGIYALAARDVFQMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLR 386

Human   376 VLEDGNQQIQVVGLQEKEVCCVEEVLNLVEIGNSCRTSRQTPVNAHSSRSHAVFQIILKSGRIMH 440
            |||||.||:|||||||:||.|||:||.|:|||||||||.||..|||||||||||||||:....:|
Frog   387 VLEDGKQQVQVVGLQEREVKCVEDVLKLIEIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLH 451

Human   441 GKFSLVDLAGNERGADTTKASRKRQLEGAEINKSLLALKECILALGQNKPHTPFRASKLTLVLRD 505
            |||||:|||||||||||:.|.|:.:|||||||||||||||||.|||:|||||||||||||.||||
Frog   452 GKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRD 516

Human   506 SFIGQNSSTCMIATISPGMTSCENTLNTLRYANRVKKLNV---DVRPYHRG-----------HY- 555
            ||||:||.|||||||||||.||||||||||||||||:..:   |: |:.:|           .|
Frog   517 SFIGENSRTCMIATISPGMASCENTLNTLRYANRVKEFGISPSDI-PFSQGSGSRSDLSPSYEYD 580

Human   556 -----------------------PIGHEAPRMLKS-----HIGNSEMSLQRDEFIKIPYVQSEEQ 592
                                   |:.|.||..|..     .:|:|.   |||: :|:...|:||:
Frog   581 DFSPTLTRVKELTVDPSAAGDLRPMIHHAPNQLDDVEALWGVGSSP---QRDD-LKLLCEQNEEE 641

Human   593 ---------KEIEEVETLPTLLGKDTTISGKGSSQWLEN---IQERAGGVHHDIDFCIARSLSIL 645
                     :.:.::..:...:.:|.....:.|.:|||:   :.|....|.:|:|....:..:||
Frog   642 VSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWLEDEKVLLEMTEEVDYDVDSYATQLEAIL 706

Human   646 EQKIDALTEIQKKLKLLLADL 666
            |||||.|||::.|:|...|.|
Frog   707 EQKIDILTELRDKVKSFRAAL 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF2B	NP_115948.4	KISc_KIF2_like	213..541	CDD:276818	256/327 (78%)
KIF2B	NP_115948.4	Kinesin	219..541	CDD:278646	250/321 (78%)
kif2a	XP_002934245.2	KISc_KIF2_like	224..552	CDD:276818	256/327 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D108002at7742
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010