Protein Alignment KISS1R and kiss1r

DIOPT Version :10

• Sequence 1: XP_047295501.1
• Gene: KISS1R / 84634
• HGNCID: 4510
• Length: 459
• Species: Homo sapiens
• Sequence 2: NP_001163985.1
• Gene: kiss1r / 100316929
• XenbaseID: XB-GENE-990075
• Length: 366
• Species: Xenopus tropicalis
• Alignment Length: 374
• Identity: 197/374 - (52%)
• Similarity: 247/374 - (66%)
• Gaps: 71/374 - (18%)

Human    31 DGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCC 95
            |.|.| |:.|||||||||||.|||:||.|||||||||.:||.||||||||||||||||:.||:.|
 Frog    32 DPPRP-PQLVDAWLVPLFFAMLMLVGLTGNSLVIYVISKHKQMRTVTNFYIANLAATDIIFLVSC 95

Human    96 VPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLAL 160
            |||||.|||||||:.|:||||||||||||||||||.||||||||||||||:||::|.:||||:|.
 Frog    96 VPFTAALYPLPGWIFGEFMCKFVNYIQQVSVQATCVTLTAMSVDRWYVTVYPLQSLRQRTPRVAA 160

Human   161 AVSLSIWVGSAAVSAPVLALHRLSP----GPRAYCSEAFPSRALERAFALYNLLALYLLPLLATC 221
            |||:.||:||..||.||...::|..    ||:.||||:|||.:.|:||.|||.|.:|||||:..|
 Frog   161 AVSVGIWIGSFIVSIPVPIYNQLIEGYWFGPQIYCSESFPSVSHEKAFILYNFLVVYLLPLITIC 225

Human   222 ACYAAMLRHLGRVAVRPAPADSALQVRGVGGRTARLGGRGGTVVGGAGGGICAGRDSPRGPGGAV 286
            .||:||:..:||.:|.  |.|::.||
 Frog   226 ICYSAMVYQMGRPSVE--PVDNSYQV--------------------------------------- 249

Human   287 RGDELSRAPAFRLTTFTAPPQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGP 351
                                  |:||||:..:|.|:||:||.:||||..|||||||:::.||..|
 Frog   250 ----------------------QLLAERSELMRTKISRMVAVIVLLFTICWGPIQLYILFQAFSP 292

Human   352 AGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCP 400
            :   ..|.|..|.:|.||:||||:||::||::|||:|::||:||.:|.|
 Frog   293 S---FKRDYYTYKVKIWANCMSYTNSSINPIVYAFMGANFRKAFNKVFP 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KISS1R	XP_047295501.1	7tm_GPCRs	43..395	CDD:475119	186/355 (52%)
		TM helix 1	45..69	CDD:410628	20/23 (87%)
		TM helix 2	78..100	CDD:410628	17/21 (81%)
		TM helix 3	116..138	CDD:410628	20/21 (95%)
		TM helix 4	161..177	CDD:410628	9/15 (60%)
		TM helix 5	202..225	CDD:410628	13/22 (59%)
		TM helix 6	323..345	CDD:410628	15/21 (71%)
		TM helix 7	363..388	CDD:410628	15/24 (63%)
kiss1r	NP_001163985.1	7tmA_KiSS1R	43..333	CDD:320223	186/355 (52%)
		TM helix 1	44..70	CDD:320223	21/25 (84%)
		TM helix 2	77..103	CDD:320223	20/25 (80%)
		TM helix 3	115..145	CDD:320223	28/29 (97%)
		TM helix 4	157..177	CDD:320223	11/19 (58%)
		TM helix 5	205..234	CDD:320223	17/28 (61%)
		TM helix 6	258..288	CDD:320223	17/29 (59%)
		TM helix 7	301..326	CDD:320223	15/24 (63%)