Protein Alignment TTBK1 and dco

DIOPT Version :10

• Sequence 1: XP_016866853.1
• Gene: TTBK1 / 84630
• HGNCID: 19140
• Length: 1409
• Species: Homo sapiens
• Sequence 2: NP_524602.1
• Gene: dco / 43673
• FlyBaseID: FBgn0002413
• Length: 440
• Species: Drosophila melanogaster
• Alignment Length: 359
• Identity: 118/359 - (32%)
• Similarity: 171/359 - (47%)
• Gaps: 64/359 - (17%)

Human    30 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFI 94
            |.:::::.:|||.|.||:||....:.|.|.||:|:|..:.....|.:|....|.:||...:.|.|
  Fly     5 VGNKYRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKHPQLHIESKFYKTMQGGIGIPRII 69

Human    95 GCGRNEKFNYVVMQLQGRNLADL-----RRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRD 154
            .||....:|.:||:|.|.:|.||     ||      |:|.|.|.|..|::..|:.|||..|:|||
  Fly    70 WCGSEGDYNVMVMELLGPSLEDLFNFCSRR------FSLKTVLLLADQMISRIDYIHSRDFIHRD 128

Human   155 IKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVR-----PPRNVAGFRGTVRYASVNAHKNR 214
            |||.||.|| |.......|::|||||:::.    |.|     |.|......||.||||:|.|...
  Fly   129 IKPDNFLMG-LGKKGNLVYIIDFGLAKKFR----DARSLKHIPYRENKNLTGTARYASINTHLGI 188

Human   215 EMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEH----------RMLLKHMPSEFH 269
            |..|.|||.||.|:|:.|.:|.|||:.:|...:    ::|||.          .:|.|..||||.
  Fly   189 EQSRRDDLESLGYVLMYFNLGALPWQGLKAANK----RQKYERISEKKLSTSIVVLCKGFPSEFV 249

Human   270 LFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWE----------------------K 312
            .:|:....:.:..:|||..:..:|.|.....|...:..|||.                      :
  Fly   250 NYLNFCRQMHFDQRPDYCHLRKLFRNLFHRLGFTYDYVFDWNLLKFGGPRNPQAIQQAQDGADGQ 314

Human   313 AGTDAL-------LSTSTSTPPQQNTRQTAAMFG 339
            ||.||:       .:.:.|:..||..:..||:.|
  Fly   315 AGHDAVAAAAAVAAAAAASSHQQQQHKVNAALGG 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTBK1	XP_016866853.1	STKc_TTBK1	33..294	CDD:271032	101/280 (36%)
		PHA03307	1083..>1376	CDD:223039
dco	NP_524602.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	103/288 (36%)