DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TEAD2 and sd

DIOPT Version :9

Sequence 1:	XP_011525701.1	Gene:	TEAD2 / 8463	HGNCID:	11715	Length:	454	Species:	Homo sapiens
Sequence 2:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster

Alignment Length:	464	Identity:	241/464 - (51%)
Similarity:	290/464 - (62%)	Gaps:	95/464 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    14 SGWTGSEEGSEEGTGGSEGAG----------GD--------GGPDAEGVWSPDIEQSFQEALAIY 60
            |.||....|.....|.::..|          ||        ...||||||||||||||||||:||
  Fly    44 SPWTPVNAGPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIY 108

Human    61 PPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKALNVD 125
            |||||||||||||||||||||||||||||||||||||||||||||||||||.||||:|:|.
  Fly   109 PPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKV---- 169

Human   126 QVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQVVQASELFQFWSGGSGPPWNVPDVKPFSQT 190
                                                       |||..|..|..: .|:|||.|.
  Fly   170 -------------------------------------------QFWQPGLQPSTS-QDIKPFPQP 190

Human   191 PFTLSLTPPSTDLPGYE---PPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVE-PPDAVD 251
            |:....|  ||.:.|.|   ||   |.||        |:.|.:.|.:.:|:||:||:| ..|.:
  Fly   191 PYPAGKT--STAVSGDETGIPP---SQLP--------WEGRAIATHKFRLLEFTAFMEIQRDEI- 241

Human   252 SYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWG 316
             |.|||||.:... ||...|.||:||:|||:||||||.|||::||::||.:||:|||.|||||..
  Fly   242 -YHRHLFVQLGGK-PSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLVKCWADLNTD 304

Human   317 -PSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYR 380
             .:|.|        :|.||||:|||||.|::.|.||:.|||||||||||||:|.::||:.|:|||
  Fly   305 LTTGSE--------TGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLENNRYVYR 361

Human   381 LLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQ 445
            :.|||||||::||:.||:.|||||||||||||||||||:..|:|||.|||.||||||:....|..
  Fly   362 IQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYVFEVAAQNSGTT 426

Human   446 HHIYRLVRD 454
            ||||||:::
  Fly   427 HHIYRLIKE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TEAD2	XP_011525701.1	TEA	40..107	CDD:128703	65/66 (98%)
sd	NP_001368984.1	TEA	88..155	CDD:128703	65/66 (98%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	130/218 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4974
eggNOG	1	0.900	-	-		E1_KOG3841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1525
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52403
OrthoDB	1	1.010	-	-		D355519at33208
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm41891
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11834
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2507
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.970