DRSC/TRiP Functional Genomics Resources

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Protein Alignment FNDC1 and flz

DIOPT Version :9

Sequence 1:NP_115921.2 Gene:FNDC1 / 84624 HGNCID:21184 Length:1894 Species:Homo sapiens
Sequence 2:NP_001137622.1 Gene:flz / 35902 FlyBaseID:FBgn0286782 Length:1693 Species:Drosophila melanogaster


Alignment Length:1847 Identity:363/1847 - (19%)
Similarity:584/1847 - (31%) Gaps:580/1847 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   320 VLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDA 384
            :::.:.:|.|....::..:.|   |:.....::.||:....|                     ..
  Fly    58 IIVASFVPTTSGFRSIETNGG---GRKLFGGYRITPKHCRAT---------------------KT 98

Human   385 LPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKA 449
            ||.::.:..      .|.:..|..:.....|:...|.:||      :||              .|
  Fly    99 LPSSDPRAN------GPTICMFNHECAQRGGEVVGACMDG------FLF--------------GA 137

Human   450 FIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLL-------- 506
            .....||...|....|...|...::.:..:...::.|.|...|.....|..:.:.:.        
  Fly   138 CCQIPPTHELASTLINEAQNAYFQQHQQQTKLQQSAAQSSFESYGEQQQSLSEEQVAQQPSQNIY 202

Human   507 -----------LDLKNKIL-ANGGAPRKPQ-----------LRAKKAEELDLQSTEITGEEELGS 548
                       ||..:.|. .||....:||           :|.:.|......|||.|..:...:
  Fly   203 DQQNLDKVYQQLDSSSSISPPNGAYGDEPQQQEYQSESEQPVRDENAYPTSSSSTEATQSQSSSA 267

Human   549 R---EDSPMSPSD-TQDQ------KRTLRPPSRHGH----SVVAPGRTA-----VRARMPALPRR 594
            .   |..|..|:| :.||      |:.::||:.|.|    ::.:|....     |...:..||..
  Fly   268 SVEFEQEPSQPADASNDQTTQKINKQPVQPPNFHVHKHSVTINSPSSPPQNDDFVMQVLSTLPPE 332

Human   595 EGVD-------------KPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVD 646
            ...|             ..|....|.....:....|::|   |:||....:|:        .:..
  Fly   333 HADDHHIVFTTEVPTKITSGLQDQTSSESNSFEEVSSTP---AATQKPKPKPT--------QMPT 386

Human   647 SDEDERAVGSLHPK---GAFAQPRPALS-----PSRQSPSSVLRDRSSVHPGAKPASPARRTPHS 703
            ....::|.....||   .|..:|.|.|:     |.:|.|..|.:.:    |..|||.......|:
  Fly   387 QKTTQKATQKPTPKPTQKAKPKPVPQLAESMKRPIQQKPQQVAKPK----PSPKPAQSTNNHHHN 447

Human   704 ----------------GAAEED-------SSASAP-PSRLSPPHGGSSRLLPTQPHLSSPLS-KG 743
                            ..|:.|       |:...| |....||.....:....|.::||..| |.
  Fly   448 HLILDGGEFTHSDITHPGADADLVEDLQFSTGYGPQPVYAEPPKQQQQQQPAEQSYISSSTSAKR 512

Human   744 GKDGEDAPAT--------------------NSNAPSRSTMSSSVSSH-------------LSSRT 775
            ...|.::|.|                    .|:.||.:.:|....|:             ..:.|
  Fly   513 PTTGHNSPTTVSSITTHVDSIESIILQLNNTSHGPSYNVVSQQTPSYGYPGAAVVQTEPAAQNPT 577

Human   776 --QVSEGAEASDGESHGD----------------GDREDGGRQAEATAQTLRARPASGH--FHLL 820
              |.:|..:..:.:|..|                .|.:|.......:|:...|||..|.  ..:|
  Fly   578 FYQENESEKVQESDSQSDYGYTTTVNYESFYDKVSDEQDASAAVSQSAEMPTARPGYGEDVSAVL 642

Human   821 RHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVP--SRAHPRVPSHSDSHPKLSSGIHGDEEDEK 883
            ......|||...:...:.      |.:|..:.:|  ..|:|...|:.              |:|.
  Fly   643 EDHTMPANGYHDAEAPVA------PQTSEFNKMPVMGIAYPVDMSYM--------------EEEG 687

Human   884 PLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKST---GADTHPQGKYSSL 945
            .||||.......||.....|     ...:.|:.:::..:||.|...:.|   .....|...|..:
  Fly   688 NLPATAAGYGQMSSDSYEAS-----TESTYQKLSTVQTEEPQPTYVRPTTNANKQNRPVASYIGM 747

Human   946 ASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPS-VPRRMTPGRAPQQQP--- 1006
            .:            .:.::|  |||:.|..|..  ||......|.: |..:|.......||.   
  Fly   748 VT------------MQHYNP--QPGNGDYQAQV--PPEVSVSSHTTKVQEQMDETSNGYQQSETT 796

Human  1007 ----PPPVATSQHHPGPQSR---DA--GRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRG 1062
                .||.|.    |.|..|   ||  |.:.|:..:.:|.:.||||....:..:...|.:..|  
  Fly   797 SGYVSPPTAV----PAPAQRPQYDAVQGDASSERPVLVTASPRPRPKPSTKRPAVKRPISGES-- 855

Human  1063 MLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRS 1127
               |..:.|.:.:.|:|:.:  ::.....|.|......|...:.: .|.|::.|:..    .|:.
  Fly   856 ---TKKKPQPQPSAGAYNQE--KISEHSTRKPVSNGYDKVPESPI-THIQIKKPSAT----QHKE 910

Human  1128 QR--GHAASPARPSRPGG-PQSRARVPSRAAPG-----KSEPPSK-----RPLSSKSQQSVSAED 1179
            |.  |:    .||:.|.| .|:.|..|:.|||.     ...|||:     .|.:|..|.:.....
  Fly   911 QEQTGY----PRPASPAGYEQTTAAAPAPAAPSLNYDKPDAPPSQYDQPSAPSASYDQLAPMPSL 971

Human  1180 DEEEDAGFFKGGKEDL---LSSSVPKWPSSSTPRGGKD-----------ADGSL---AKEEREPA 1227
            :..|......|.|...   :|:|....||:..|....|           ||..|   .:...|..
  Fly   972 NYNEQHASSPGRKPSTAKPISTSYVTGPSTPRPPATVDYHYDNVPPLFMADDKLDAFIQSTAENI 1036

Human  1228 IALAPRGGSLAPVKRPLPPPPGSSPRASHVPSR------------------LPPRSAATVSP--- 1271
            :...|  |:..|   || ....|:|..:|.|:.                  .|||....::|   
  Fly  1037 VGSTP--GNYQP---PL-VATASTPAYAHRPTSSGSYGHKKPGFVQINGTPKPPRPTVLITPKPT 1095

Human  1272 -----------------VAGTHPWPQYTTRAP------------PGHFSTTPM-LSLRQRMMHAR 1306
                             .:.|   ..|.|..|            ||:|.::|: ::..|....|.
  Fly  1096 AINLVTYSSLSDDSNKLASST---SSYVTGRPGVQGVSSNDFKDPGYFGSSPVHVAFTQSTTEAV 1157

Human  1307 FRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSN----------GKPNGQRIINGP---------- 1351
            :..|...:||.|.|   :...|:.....:||..          ..||.  .:|.|          
  Fly  1158 YAVPSDDKPAFPGY---FGPTPSYPAFSVPGEKVGQNVMEETYTSPND--FVNFPPVRNPNLNMS 1217

Human  1352 -QGTKWVVDLDRGLVLNAEGRYLQDS-HG--NPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQG 1412
             ..:....|||.......|...|:|. |.  :.|...|.|:...:.|:...| .|...:..:..|
  Fly  1218 AASSAVTSDLDLSTPAFVEDVVLKDKMHTLVHKLVASLQGNFEALADMIEEP-GSNKTVATYQAG 1281

Human  1413 RHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTT-TTTPLP-------TTTTPRP- 1468
            ..||.      ||:..:..:..|....   ||.|..||.:|.| .||..|       :|||.:| 
  Fly  1282 AGGTA------KPVRVVTTRKPVRTAT---TTRPKVTTKKPVTRVTTKAPNKKTSAVSTTTRKPA 1337

Human  1469 ---TTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSS 1530
               ||...:.||||||..|::||..|.:|.:|||.::..|.               ||       
  Fly  1338 TRRTTVAAKVTTTTRRPATKKPTRRVSSTVKTTTVSSARPA---------------DD------- 1380

Human  1531 NGIPECYAEEDEF------SGLETDTAVPTEEAYVIYDEDYEFETSRP-PTTT----EPSTT--- 1581
                |...||||.      |..|.|... |..:|...:......|||. ||..    .|||.   
  Fly  1381 ----EIVDEEDEEDVNPNPSDNEIDQGA-TLSSYGGANGRKIHSTSRTLPTPNLAFHSPSTECGV 1440

Human  1582 ---ATTPRVIPEEGAISSFPEEEFDLAGRK-------------------RFVAPYVTYLNKDPSA 1624
               ..:.|::..:|  |:|....:.:..|:                   |:|   :|..:..|..
  Fly  1441 RPHVKSGRIVGGKG--STFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYV---ITAAHCQPGF 1500

Human  1625 PCSLTDALDHFQV----DSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDK----- 1680
            ..||...:..|.:    :|...:..| :|:..:..|:.|....       :...:::.|.     
  Fly  1501 LASLVAVMGEFDISGDLESKRSVTKN-VKRVIVHRQYDPATFE-------NDLALLELDSPVQFD 1557

Human  1681 ------ATPGDV---------VTGY--LVYSASYEDFIRNKW-----STQASSVTHLPIENLKPN 1723
                  ..|.||         |||:  |.|.......::...     ::....:.|....|.|..
  Fly  1558 THIVPICMPNDVADFTGRMATVTGWGRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKIL 1622

Human  1724 TRY----YFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGR 1784
            |.:    |...|..:..|            :|..||::.||.|          :::.:.|..||.
  Fly  1623 TSFLCAGYANGQKDSCEG------------DSGGPLVLQRPDG----------RYELAGTVSHGI 1665

Human  1785 Q---------YVKRT----WYRKFVGV 1798
            :         |::.|    |.|...||
  Fly  1666 KCAAPYLPGVYMRTTFYKPWLRSITGV 1692

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FNDC1NP_115921.2 FN3 40..120 CDD:214495
FN3 158..241 CDD:214495
FN3 261..354 CDD:238020 4/33 (12%)
FN3 362..452 CDD:238020 11/89 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..500 9/44 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 515..1271 192/950 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1350 9/48 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1444..1515 30/82 (37%)
FN3 1658..1749 CDD:238020 17/121 (14%)
flzNP_001137622.1 PRK14948 <272..452 CDD:237862 40/194 (21%)
PRK11633 <365..>439 CDD:236940 20/88 (23%)
PRK10263 <547..>1005 CDD:236669 108/518 (21%)
PHA03247 <792..1096 CDD:223021 73/329 (22%)
Tryp_SPc 1449..1689 CDD:238113 45/274 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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