DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KIRREL3 and dpr3

DIOPT Version :9

Sequence 1:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens
Sequence 2:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	282	Identity:	58/282 - (20%)
Similarity:	104/282 - (36%)	Gaps:	70/282 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDASLGAGLRCSGIASSPLRMQQNELGLQKRGCCLVLGYMAKDKFRRMNEGQ---VYSFSQQPQD 62
            :|||.|:.|           ..|.:...::.|.       |.::.:..:..|   ::.|. .|::
  Fly   200 LDASFGSDL-----------FAQTDAKRERSGA-------ADEESQDADTSQSLPIFDFG-MPRN 245

Human    63 QVVVSGQPVTLL-CAIPE-YDGFVLWI--KDGLALGVG-RDLSSYPQYLVVGNHLSGEHHLKILR 122
            ....:|....:: |.:.. :|..|.||  :|...|.|| ...:|..::.|..:..|.|..|.:..
  Fly   246 ITGRTGHTEAIIKCRVDSLHDKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKDSREWTLHVKA 310

Human   123 AELQDDAVYECQAIQAAIRSRPARLTVL-VPPDDPVILGGPV-ISLRAGDPLNLTC--HADNAKP 183
            ...:|..:||||.......|...:|.:: :.||...::.||. :..:||..:.|.|  ...:.|.
  Fly   311 PLAKDSGIYECQVNTEPKMSMAFQLNIIEISPDAKAVISGPPDLHFKAGSAIILNCLVQQPSVKD 375

Human   184 AASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSV 248
            ...|.|.| ||.:                       |:|.|.::||        ..||.|:.
  Fly   376 IGPIYWYR-GEHM-----------------------ITPFDADDGQ--------PEIPAGRG--- 405

Human   249 TIDIQHPPLVNLSVEPQPVLED 270
                :||..:.....|..::.:
  Fly   406 ----EHPQGIPEDTSPNDIMSE 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845	23/95 (24%)
		IG_like	60..149	CDD:214653	23/93 (25%)
		I-set	156..249	CDD:254352	20/95 (21%)
		Ig2_KIRREL3-like	171..252	CDD:143236	16/82 (20%)
		Ig_2	260..337	CDD:290606	1/11 (9%)
		I-set	341..422	CDD:254352
		IGc2	355..406	CDD:197706
		Ig5_KIRREL3	424..521	CDD:143306
		IG_like	432..521	CDD:214653
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	21/86 (24%)
		IG_like	243..329	CDD:214653	21/85 (25%)
		Ig	350..464	CDD:299845	23/113 (20%)
		IG_like	<441..477	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810