DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIRREL3 and kirre

DIOPT Version :9

Sequence 1:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	805	Identity:	215/805 - (26%)
Similarity:	331/805 - (41%)	Gaps:	154/805 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    49 NEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLS 113
            |.||  .|:.:||||..|.|..|||.|.:.|..|.:.|.||...||..|:||.:.:|.:||:...
  Fly    79 NGGQ--HFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDEE 141

Human   114 GEHHLKILRAELQDDAVYECQA-----IQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLN 173
            |:..|.|....|.|||.|:||.     .:..||||.|:|||||||:.|.|..|..:.......:.
  Fly   142 GDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIE 206

Human   174 LTCHADNAKPAASIIWL-RKGEVI-NGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRAT 236
            |.|.:...||||.|.|: ..|.|: .|..|.|..|.|.:|.:..|.|.::|....:..:..|:|.
  Fly   207 LECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQ 271

Human   237 NKAIPGGKETSVTIDIQHPPLVNLSV-----EPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQI 296
            |.|....:...:.:::::.|.|.:||     ....:.|...|...|.|.|||....|||....::
  Fly   272 NTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDEL 336

Human   297 IKEASGEVYRTTVDYT-----------YFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSL 350
            :          |.|:|           |....|.|||.||:|.:..|:.:|:.|||.....|.|:
  Fly   337 M----------TGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSV 391

Human   351 LVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVV---PRVG 412
            ..|||:.....|...|||...|.|:...|..|:.....|.|| |..|.||:|.|:|||   |.:|
  Fly   392 EADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKLK-VSSETAGRYFCKAVVNGFPEIG 455

Human   413 AGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENV--LESGTSGRYT 475
            |   |.||.|...|||:|.:.|....|.:.:|.|...|.|..:.|.||::..:  :.|.....|.
  Fly   456 A---EATLYVKRAPIITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYI 517

Human   476 VETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIR-LKEQGSEMKSGAGLEAESVP 539
            .|.....|||.:.|.|.:.....|.. ||||..||:|.|:.:|. |:|.|            ::|
  Fly   518 FEEHHLPEGVRAALIIRDSKATHFGK-YNCTVMNSYGGDSLVITLLREPG------------NIP 569

Human   540 MAVIIGVAVGAGVAFLVLMATIVAFCCARSQRSTGGRSGI--SGRGTEKKARLRLPRRANLKGVV 602
            :.:::..::......|:::..|:.:...||::.......|  :.||.:|...|
  Fly   570 VLLVVMGSMFCVAIILMIVMIIIVYRKRRSRKKPMPADVIPEASRGGDKLNEL------------ 622

Human   603 SAKNDIR---VEIVHKEPASGREGEEHSTIKQLMMD----------------------RGEFQQD 642
              |:::|   .::.:.|  :|.:|...:..:..|.|                      .|:|..|
  Fly   623 --KSELRSKAYDVEYSE--AGGDGLAINLTQSPMPDVQMKGATLGVPLAGPVKFDERFSGDFGGD 683

Human   643 SVLKQLEV--LKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMS 705
            ...:|..:  ||.:::.........|||       .|:                         ..
  Fly   684 RYNRQCHIKNLKNQQETAYKGSPQANGY-------AHY-------------------------FE 716

Human   706 FTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDG 770
            :...||...|:      |...|:|.|...      :.:.|.:  :|:.|.....::|:..|..:|
  Fly   717 YALDYSPPGGE------GAAVVVGSGGVG------KLKNGGM--NSATLPHSAAATVNGGGAGNG 767

Human   771 YVQFDKASKASASSSHHSQSSSQNS 795
                 ..:....:..|..|.|.|::
  Fly   768 -----GGASLPRNQRHEIQQSQQSN 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845	39/95 (41%)
		IG_like	60..149	CDD:214653	39/93 (42%)
		I-set	156..249	CDD:254352	26/94 (28%)
		Ig2_KIRREL3-like	171..252	CDD:143236	23/82 (28%)
		Ig_2	260..337	CDD:290606	24/92 (26%)
		I-set	341..422	CDD:254352	32/83 (39%)
		IGc2	355..406	CDD:197706	18/50 (36%)
		Ig5_KIRREL3	424..521	CDD:143306	31/99 (31%)
		IG_like	432..521	CDD:214653	27/91 (30%)
kirre	NP_001245505.1	Ig	87..183	CDD:299845	40/95 (42%)
		IG_like	88..182	CDD:214653	39/93 (42%)
		C2-set_2	189..279	CDD:285423	26/89 (29%)
		Ig_2	307..379	CDD:290606	23/81 (28%)
		I-set	382..462	CDD:254352	32/83 (39%)
		IGc2	396..446	CDD:197706	18/50 (36%)
		Ig	466..561	CDD:299845	31/95 (33%)
		IG_like	478..561	CDD:214653	26/83 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148506
Domainoid	1	1.000	87	1.000	Domainoid score	I7984
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3128
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm8470
orthoMCL	1	0.900	-	-		OOG6_103358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3009
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.690