DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIRREL3 and kirrel3

DIOPT Version :9

Sequence 1:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens
Sequence 2:	XP_031761736.1	Gene:	kirrel3 / 105947809	XenbaseID:	XB-GENE-922296	Length:	773	Species:	Xenopus tropicalis

Alignment Length:	782	Identity:	652/782 - (83%)
Similarity:	709/782 - (90%)	Gaps:	27/782 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    28 LQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLA 92
            |..|...|.||:|:|||||:|:||| .||:|||||||||:||||:||||||.|.|.:||||||||
Frog    19 LLSRESGLTLGFMSKDKFRKMSEGQ-SSFTQQPQDQVVVAGQPVSLLCAIPGYHGLLLWIKDGLA 82

Human    93 LGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPV 157
            :|||||||.||:|.|.|:||||||||.|.||||||||:|||||||||||||||||||||||||||
Frog    83 IGVGRDLSGYPRYSVGGDHLSGEHHLMIQRAELQDDAMYECQAIQAAIRSRPARLTVLVPPDDPV 147

Human   158 ILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISP 222
            |.||||||:|||||||||||||||||||:|.|::.|||:|||||.||||||||||||:||||:|.
Frog   148 ITGGPVISIRAGDPLNLTCHADNAKPAATITWMKNGEVLNGATYYKTLLRDGKRESIISTLFVSS 212

Human   223 GDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQ 287
            .|:||||:|.|||||||:|||||.:|||:|||||||||:||||||||||||.|||:|||||||||
Frog   213 SDIENGQTITCRATNKAVPGGKEATVTINIQHPPLVNLTVEPQPVLEDNVVKFHCAAKANPAVTQ 277

Human   288 YRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLV 352
            |||||.|||:||.:.|.|.|.||:::|:|||||||||||||||:||||||||||||::||:|:.|
Frog   278 YRWAKGGQILKEVTDETYETVVDFSFFTEPVSCEVTNALGSTNVSRTVDVYFGPRMSSEPESITV 342

Human   353 DLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGERE 417
            ||||||.|.|||.|||||||||||||||||||||.|||||:|||||||||||||||||||||||:
Frog   343 DLGSDATFHCAWIGNPSLTIVWMKRGSGVVLSNENTLTLKNVRQEDAGKYVCRAVVPRVGAGERD 407

Human   418 VTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTE 482
            ::|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||:
Frog   408 ISLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETVSTD 472

Human   483 EGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVA 547
            ||||||||||||||||||||||||||||||||||||||||||..|:||..:|.||||:.||||||
Frog   473 EGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGPNMQSGTSMEPESVPVTVIIGVA 537

Human   548 VGAGVAFLVLMATIVAFCCARSQRSTGGRSGISGRGTEKKARLRLPRRANLKGVVSAKNDIRVEI 612
            |||||||||||||||||||||:||                         ||||||||||||||||
Frog   538 VGAGVAFLVLMATIVAFCCARNQR-------------------------NLKGVVSAKNDIRVEI 577

Human   613 VHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEH 677
            |||||::|||.|:||||||||:|||||||||||||||||||||||||||||||||||||||||:
Frog   578 VHKEPSTGRETEDHSTIKQLMIDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKD- 641

Human   678 HSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREF 742
            |||||||||:||.|||||.||||||||||||||||||||.|||||.|||||||||||||||||||
Frog   642 HSTPTISLSNCQQDLRPANKQRVPTGMSFTNIYSTLSGQNRLYDYSQRFVLGMGSSSIELCEREF 706

Human   743 QRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQT 807
            ||||:|||||||||||||||||||||||||||||:|||||||||:|||||||||||:||||||||
Frog   707 QRGSMSDSSSFLDTQCDSSVSSSGKQDGYVQFDKSSKASASSSHYSQSSSQNSDPSKPLQRRMQT 771

Human   808 HV 809
            ||
Frog   772 HV 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845	75/90 (83%)
		IG_like	60..149	CDD:214653	73/88 (83%)
		I-set	156..249	CDD:254352	73/92 (79%)
		Ig2_KIRREL3-like	171..252	CDD:143236	63/80 (79%)
		Ig_2	260..337	CDD:290606	60/76 (79%)
		I-set	341..422	CDD:254352	67/80 (84%)
		IGc2	355..406	CDD:197706	45/50 (90%)
		Ig5_KIRREL3	424..521	CDD:143306	94/96 (98%)
		IG_like	432..521	CDD:214653	86/88 (98%)
kirrel3	XP_031761736.1	IG	50..139	CDD:214652	73/88 (83%)
		IgI_2_KIRREL3-like	145..242	CDD:409416	77/96 (80%)
		Ig strand B	162..166	CDD:409416	3/3 (100%)
		Ig strand C	176..180	CDD:409416	1/3 (33%)
		Ig strand E	206..210	CDD:409416	3/3 (100%)
		Ig strand F	220..225	CDD:409416	2/4 (50%)
		Ig strand G	235..238	CDD:409416	1/2 (50%)
		Ig	331..412	CDD:416386	67/80 (84%)
		Ig strand A'	339..343	CDD:409353	1/3 (33%)
		Ig strand B	346..356	CDD:409353	7/9 (78%)
		Ig strand C	361..367	CDD:409353	5/5 (100%)
		Ig strand E	377..383	CDD:409353	4/5 (80%)
		IgI_5_KIRREL3	414..511	CDD:409479	94/96 (98%)
		Ig strand B	432..436	CDD:409479	3/3 (100%)
		Ig strand C	446..450	CDD:409479	3/3 (100%)
		Ig strand E	477..481	CDD:409479	3/3 (100%)
		Ig strand F	492..497	CDD:409479	4/4 (100%)
		Ig strand G	505..508	CDD:409479	2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	492	1.000	Domainoid score	I3868
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1335	1.000	Inparanoid score	I1826
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D116854at7742
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		oto148274
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060