DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PARD6B and GUK1

DIOPT Version :9

Sequence 1:	NP_115910.1	Gene:	PARD6B / 84612	HGNCID:	16245	Length:	372	Species:	Homo sapiens
Sequence 2:	NP_010742.1	Gene:	GUK1 / 852065	SGDID:	S000002862	Length:	187	Species:	Saccharomyces cerevisiae

Alignment Length:	163	Identity:	34/163 - (20%)
Similarity:	62/163 - (38%)	Gaps:	49/163 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   217 EVNGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRNNVVRNSRTSGSSGQSTDNSLLGYPQQIE 281
            ||||.:.:..|:|:...|:               :.|..:..::.||:...||..|:    :|:.
Yeast    45 EVNGKDYNFVSVDEFKSMI---------------KNNEFIEWAQFSGNYYGSTVASV----KQVS 90

Human   282 PSFEPEDEDSEEDDIIIEDNGVP--QQIPK--------AVPNTESLESLTQIELSFESGQNGFIP 336
            .|       .:...:.|:..||.  :.||:        |.|:.|.|:...:          |...
Yeast    91 KS-------GKTCILDIDMQGVKSVKAIPELNARFLFIAPPSVEDLKKRLE----------GRGT 138

Human   337 SNEVSLAAIASSSNTEF---ETHAPDQKLLEED 366
            ..|.|:....|::..|.   ||.|.|:.::.:|
Yeast   139 ETEESINKRLSAAQAELAYAETGAHDKVIVNDD 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PARD6B	NP_115910.1	PB1_Par6	17..96	CDD:99724
		Interaction with PARD3 and CDC42. /evidence=ECO:0000250	126..253		7/35 (20%)
		PDZ_signaling	156..247	CDD:238492	7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..292		8/38 (21%)
GUK1	NP_010742.1	guanyl_kin	3..185	CDD:213788	34/163 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910