Protein Alignment FOXN1 and fkh

DIOPT Version :10

• Sequence 1: XP_011523660.1
• Gene: FOXN1 / 8456
• HGNCID: 12765
• Length: 649
• Species: Homo sapiens
• Sequence 2: NP_001263038.1
• Gene: fkh / 43383
• FlyBaseID: FBgn0000659
• Length: 692
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 149/689 - (21%)
• Similarity: 211/689 - (30%)
• Gaps: 237/689 - (34%)

Human    56 PPERTPSLPPHSPRIASPG----PEQVQGHCPAGPGPGPFRLSPSDKYPGFGFEEAAASSPGRFL 116
            ||   ||..|.|  :||.|    |....|....|.|.||  ..||:..|.       .:|.|
  Fly     8 PP---PSSAPVS--MASSGGGGPPSGGGGGGGGGGGGGP--PPPSNNNPN-------PTSNG--- 55

Human   117 KGSHAPFHPYKRPFHEDVFPEAETTLALKGHSFKTPGPLEAFEEIPVDVAEAEAFLP-------G 174
             ||.:       |.....:......|.:.|.|..:|.....|....:|.|.|.|.:.       .
  Fly    56 -GSMS-------PLARSAYTMNSMGLPVGGMSSVSPQAAATFSSSVLDSAAAVASMSASMSASMS 112

Human   175 FSAEAWCNGLPYPSQEHGPQVLQGSEVKVKPPVLESGAGMFCYQPPLQHM-YCSSQPPFHQYSPG 238
            .|..|..||      ..|...:.........|...|.|.|   ..||.:| .|.:.......:.|
  Fly   113 ASMNASMNG------SMGAAAMNSMGGNCMTPSSMSYASM---GSPLGNMGGCMAMSAASMSAAG 168

Human   239 -GGSYPIPYLGSSHYQ-----------------YQRMAPQASTDGHQPLFPKPIYSYSILIFMAL 285
             .|:|.....||...:                 |:|....|          ||.|||..||.||:
  Fly   169 LSGTYGAMPPGSREMETGSPNSLGRSRVDKPTTYRRSYTHA----------KPPYSYISLITMAI 223

Human   286 KNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKV---ENKSGSSSRKGCLW 347
            :|:.|..|.:||||.|:.:.||:::.....|:||:||:||.|.||.|:   .:|.|    ||..|
  Fly   224 QNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPG----KGSFW 284

Human   348 ALNPAKIDKMQ-----EELQKWKRKDPIAVRKSMAKP--EELDSLIGDKREKLGSPLLGCPPPGL 405
            .|:|...:..:     ...:::|.:...|:|:....|  ..|::....|::...|
  Fly   285 TLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEATSPGKKDHEDS---------- 339

Human   406 SGSGPIRPLAPPAGLSPPLHSLH--------------PAPG-PIPGKNPLQDLLMGHTPSCYGQT 455
                               |.:|              .|.| .|.|.|.|.   ..|:.......
  Fly   340 -------------------HHMHHHHHSRLDHHQHHKEAGGASIAGVNVLS---AAHSKDAEALA 382

Human   456 YLHLSPGLAPPGPPQPLFPQPDGH---------------LELRAQPGTPQD-----SPL----PA 496
            .||.:..|.....||.:   |..|               :..|..|....|     .||    ..
  Fly   383 MLHANAELCLSQQPQHV---PTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEPSG 444

Human   497 HTPPSHS---AKLLAEP-------------------SPARTMHDTLLPDG---DLGTDLDAINPS 536
            :||.||.   .:||...                   ||....|..|..|.   .||....|...|
  Fly   445 YTPSSHPFSINRLLPTESKADIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTTS 509

Human   537 LTDFDF-------------------------------QGNLWEQLKDDSLALDPLVLVTSSPTSS 570
            |....:                               |..|.:|.:....:...|...:::|.:|
  Fly   510 LXHHQYPLAXGRAEQMLRSQQQQHLQQQHQQHQQQQQQHQLHQQQQQMQQSAQQLTSASNTPATS 574

Human   571 SMPPPQPPPHCFPPGPCLTETGSGAGDLAAPGSG-GSGA 608
            :                  :....||..:|.||| |||:
  Fly   575 A------------------KASGKAGSASASGSGSGSGS 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXN1	XP_011523660.1	FH_FOXN1	271..367	CDD:410830	38/103 (37%)
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:369872	18/97 (19%)
		FH_dFKH	210..307	CDD:410815	37/100 (37%)