Protein Alignment FOXN1 and FoxL1

DIOPT Version :10

• Sequence 1: XP_011523660.1
• Gene: FOXN1 / 8456
• HGNCID: 12765
• Length: 649
• Species: Homo sapiens
• Sequence 2: NP_523912.1
• Gene: FoxL1 / 38471
• FlyBaseID: FBgn0004895
• Length: 365
• Species: Drosophila melanogaster
• Alignment Length: 473
• Identity: 116/473 - (24%)
• Similarity: 165/473 - (34%)
• Gaps: 154/473 - (32%)

Human   180 WCNGLPYPSQEH-------GPQVLQGSEVKVKP--PVLESGAGMFCYQPPLQHMYCSSQPPFHQY 235
            :.||...|..|.       .|..|: ::|...|  |....||||       :.:.|.|..|...|
  Fly     6 YANGSMLPDNEELVNSMLANPDYLR-TQVSPNPLAPSAVGGAGM-------EGLMCGSFSPAFYY 62

Human   236 SPGGGSY----------PIPYLGSSHYQYQRMAPQASTDGHQPLFPKPIYSYSILIFMALKNSKT 290
            . |..|:          ||.:|.:||      .|:           ||.:||..||.||:.::..
  Fly    63 Q-GIDSFLALHNNIWGLPISFLHNSH------RPE-----------KPPFSYIALIAMAISSAPN 109

Human   291 GSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVEN-----KSGSSSRKGCLWALN 350
            ..|.:|.||.|:.:.|||::....||:||:|||||||.||.|:..     :...|:.||..|.|:
  Fly   110 QRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLD 174

Human   351 PAKIDKMQEELQKWKRKDPIAVRKSMAKPEELDSLIG-DKREKLGSPLLGCPPPGLSGSGPIRPL 414
            .:..|..::...:.:|   ...::....|...:...| |..:            |.|.:..||
  Fly   175 SSASDMFEQGNYRRRR---TRRQRHCGHPNRYERESGKDSND------------GNSSAAEIR-- 222

Human   415 APPAGLSPPLHSLHPAPGPIPGKNPLQDLLMGHTPSCYG-------QTYLHLSPGLAPPGPPQPL 472
            :|    |.||...              |:.....|: |.       :.||.:|.|.      ..|
  Fly   223 SP----SEPLSDF--------------DIFCNERPN-YSDRITDLHRQYLSVSLGF------NSL 262

Human   473 FPQPDGHLELRAQPGTPQDSPLPAHTPPSHSAKLLAEPSPARTMHDTLLPDGDLGTDLDAINPSL 537
            |......|.           |||.          :.|           .||     |:||.:.|.
  Fly   263 FNNEARGLR-----------PLPE----------IRE-----------CPD-----DVDASSSSS 290

Human   538 TDFDFQGNLWEQLKDDSLALDPLVLVTSSPTSSSMPPPQPPPHCFPPGPCLTETGSGAGDLA-AP 601
            ........|.|:|...|....||   ....||||            ..|.|.|..:|..|:. ||
  Fly   291 KAMQSSMELHEELHSPSAFTPPL---NRRETSSS------------GAPVLAEAFNGIKDVVDAP 340

Human   602 GSGGSGALGDLHLTTLYS 619
            || ...|..:...|||::
  Fly   341 GS-SPVASSNRSKTTLFT 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXN1	XP_011523660.1	FH_FOXN1	271..367	CDD:410830	36/100 (36%)
FoxL1	NP_523912.1	FH_FOX	89..186	CDD:469596	37/107 (35%)