Protein Alignment FOXN1 and CHES-1-like

DIOPT Version :10

• Sequence 1: XP_011523660.1
• Gene: FOXN1 / 8456
• HGNCID: 12765
• Length: 649
• Species: Homo sapiens
• Sequence 2: NP_511071.3
• Gene: CHES-1-like / 31678
• FlyBaseID: FBgn0029504
• Length: 1268
• Species: Drosophila melanogaster
• Alignment Length: 492
• Identity: 136/492 - (27%)
• Similarity: 182/492 - (36%)
• Gaps: 148/492 - (30%)

Human     3 SLPPPQSDV--------TLPGPTRLEGERQGDLMQAPG---LPGS-PAPQSKHAGFSCSSF---- 51
            :|||..|.|        .|..|..:....     ..||   |||: .|..:..||.:.::.
  Fly   517 TLPPGYSFVNQVASTPHVLSTPAHVASPE-----TPPGAALLPGTYYATSTTSAGTTTTTLQARS 576

Human    52 ----VSDGPPERTPSLPPHSPRIASPGPEQVQGHCPAGPGPGPFRLSPSDKYPGFGFEEAAASSP 112
                ||..||..||:...|:..:...|        ..|.|.|          .|.|...|...||
  Fly   577 LQLSVSPPPPNMTPTSQVHNGSLGGGG--------GGGGGSG----------GGGGGGGANLRSP 623

Human   113 GRFLKGSHAPFHPYKRPFHEDVFPEAETTLALKGHSFKTPGPLEAFEEIPVDVAEAEAFLPGFSA 177
                 .|:|.:.      :||...|.:..::.:.|: .||                :..:....|
  Fly   624 -----NSYASYD------NEDSLKEFDLVVSSRLHT-STP----------------QYSVSKNGA 660

Human   178 EAWCNGLPYPSQEHGPQVLQGSEVKVKPPVLESGAGMFCYQPPLQHMYCSSQPPFHQYSPGGGSY 242
            ..:.||   .|..:|                 ||||              |..|..|..|..
  Fly   661 NGYGNG---NSNVNG-----------------SGAG--------------SNTPQKQKHPNN--- 688

Human   243 PIPYLGSSHYQYQRMAPQASTDGHQPLFPKPIYSYSILIFMALKNSKTGSLPVSEIYNFMTEHFP 307
             :||           .|...|:.      ||.||:|.|||||::.|...:|||.|||.::.:|||
  Fly   689 -VPY-----------DPLVHTNN------KPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFP 735

Human   308 YFKTAPDGWKNSVRHNLSLNKCFEKVENKSGSSSRKGCLWALNPAKIDKMQEELQKWKRKDPIAV 372
            ||||||:||||||||||||||.|.|||  ...:..||.||.:.|.:...:.:.|.:.......||
  Fly   736 YFKTAPNGWKNSVRHNLSLNKSFVKVE--KAPNMGKGSLWRVEPQQRQNLIQALNRSPFFPNSAV 798

Human   373 RK---SMAKP---EELDSLIGDKREKLGSPLLGCPPPGLSGSGPIRPLAPPAGLSPPLHS--LHP 429
            .|   |:..|   ...|||.|.     ||..:....|...|:|.  |.|....||.|..|  |..
  Fly   799 DKISPSLKSPSGGSAYDSLDGG-----GSGSVSSAQPVAGGAGV--PAAAAVALSTPTKSNGLAL 856

Human   430 APGPIPGKNPLQDLLMGHTPSCYGQ-TYLHLSPGLAP 465
            |.|.....|..:.    |:|:..|. ::....|.|.|
  Fly   857 ANGASQATNAARP----HSPNGGGSGSHARFDPYLFP 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXN1	XP_011523660.1	FH_FOXN1	271..367	CDD:410830	50/95 (53%)
CHES-1-like	NP_511071.3	FH_FOXN2-like	700..775	CDD:410805	48/76 (63%)