DRSC/TRiP Functional Genomics Resources

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Protein Alignment TMEM185A and CG14194

DIOPT Version :10

Sequence 1:NP_115897.1 Gene:TMEM185A / 84548 HGNCID:17125 Length:350 Species:Homo sapiens
Sequence 2:NP_573360.1 Gene:CG14194 / 32908 FlyBaseID:FBgn0030996 Length:358 Species:Drosophila melanogaster


Alignment Length:364 Identity:159/364 - (43%)
Similarity:228/364 - (62%) Gaps:20/364 - (5%)


- Green bases have known domain annotations that are detailed below.


Human     1 MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVW 65
            |||..||:||||.||:::..|.:|..|.|||||..|.|.|||:|.|:|:||...|:||.||..||
  Fly     1 MNLESLFRDFNPCKFIVHCSLFIFVTLFALRLDNYIDWPYWAIFTPLWIWKCTAILGAIVGAIVW 65

Human    66 ARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAAC 130
            .|.|.||.||:...:||||||::.:||:|||||:|.||::....|.|:|||:||.|.|.|||.||
  Fly    66 CRYPHYRLEGDAYTQFKAMLISLALHLILLMFELLACDKLTSDRHLWVLVFIPLIFGSVVSVGAC 130

Human   131 VWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVL 195
            ||..:||||.|||:..:||.|||:.:.|:||:.::|.|.||.||:||::....:.|||.|::..:
  Fly   131 VWAVKHDRSFELELFLAVNALQFVSLPLKLDRFVYWNWDVVFVPMWIVICLSLVSVLYNIIFCGI 195

Human   196 FLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMAT 260
            .:|:.:|..:|::..:..|:..:..|:|||.|::::..||||...|..|.:|.||.:|::.|:..
  Fly   196 MMRTPEVSLQQKKAALNAAVGNICTVLPLLCFQVVICDKLDGELKFPYIVVFSPLLVSILALIVL 260

Human   261 TFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDNEETEET-PVPEPPKIAPM--- 321
            :...||||.|||||||.|.||||...|||:|||||||  |.|.:....:: |:........|   
  Fly   261 SSSAKGGNMWWFGIRKSFSQFLLSAMPFLQEYGNISY--HPETHSNAAQSMPLDAASSSTSMAAS 323

Human   322 --------FRKKARVVITQSPGKYVLPP--PKLNIEMPD 350
                    ..||::    :.....:|.|  |.::|::||
  Fly   324 EQLHEFHKHDKKSK----KGAKNDILKPVVPFVSIDLPD 358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TMEM185ANP_115897.1 Tmemb_185A 31..253 CDD:402059 103/221 (47%)
Mediates interaction with MAP1B. /evidence=ECO:0000269|PubMed:15525354 298..350 10/65 (15%)
CG14194NP_573360.1 Tmemb_185A 30..253 CDD:402059 104/222 (47%)

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