DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CUL1 and Cul6

DIOPT Version :9

Sequence 1:	NP_001357589.1	Gene:	CUL1 / 8454	HGNCID:	2551	Length:	776	Species:	Homo sapiens
Sequence 2:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	204/783 - (26%)
Similarity:	348/783 - (44%)	Gaps:	161/783 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGA 81
            ::||:||        ||  |....:.|.||..:|..|.:....|.      |..|:
  Fly    25 VNQIFDD--------YT--SFDGQKLMHLYHLIYKQCAAERNWNN------PAQKN--------- 64

Human    82 QFVGLELYKRLKEFLKNYLTNLLKDGEDLMDES----VLKFYTQQWEDYRFSSKVLNGICAYLNR 142
               |..||..|.:.|...|.|:....|:.:|::    ::..|.:.|..|:.|.:.||..|.:.||
  Fly    65 ---GRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNR 126

Human   143 HWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQS 207
            :||.||..:|.|..|.||.||:::|::.:|.|   .||  :|..|           |||
  Fly   127 NWVERERLKGDKETYPIYRLAMISWKELVFEP---SVT--ILAAI-----------RLI------ 169

Human   208 YVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEE- 271
                                                        |.|.| .||.|..|.::.:.
  Fly   170 --------------------------------------------LSQMP-REYNKSLEYQVYQVL 189

Human   272 QRRVQVYLHESTQD-ELARKCEQVLIEKHLEIFHT----EFQNLLDADKNEDLGRMYN----LVS 327
            |..|::|.::..|| .|..:.:::..||.::.:.:    |||.::.::..:|......    .:.
  Fly   190 QSIVELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMP 254

Human   328 RIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFV 392
            .|::|. :.|.:|:.:     |||  :..|..|:. |.|:|..|.:.:   ..:..|..:.....
  Fly   255 EIENGT-QFKAILKRY-----LAA--RLQETRLSG-KDYIQAFLGLCR---GPLQRALRDHTKLA 307

Human   393 AALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIE 457
            ..:|..|...||...      .......||..|.:.|:.|..:: ||| :.|.|.:::...:::.
  Fly   308 EVVDAVCKEEINRKG------QIIDPTRLLVTYANELMTKRQES-EEA-IIDELKRIVKCVEFLS 364

Human   458 DKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFK 522
            |:..|...|.|.|..|.:::.|.||..|:.|.|.|.:......|..:....:|:...:.|.::|:
  Fly   365 DEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQ 429

Human   523 KHLTNSEPLDLDFSIQ---VLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRK--LTWL 582
            .|| ||:.:.|.|..:   ..:.||:   ::....||.||:::::.|..||.:|....|  :...
  Fly   430 DHL-NSKGIKLGFDFRPKCFKNDGSF---ENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLN 490

Human   583 YQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSK 647
            .:||.||:..:..::.|.|:.||.|||:|:.:|..:.:|.|:|..:..::::.|.:.|:   :.|
  Fly   491 NELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALK---QIK 552

Human   648 LLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPM-----KTEQKQEQETTHKNIEEDR 707
            .||..:.| .|:.:|:..|        :.|:|.|:..|.|:     |.|:|.|.|.   .|..|:
  Fly   553 FLVYIEVN-KVNYIEINMD--------FTNRKRRLFCNEPLPRKMRKIEEKSEIEL---KIRRDK 605

Human   708 KLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTY 772
            :  :.||||||||.:|.|::.:|:..|..:|..|.||:|..|||.:|.|:|:||||| |...:.|
  Fly   606 Q--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLER-DNYYNIY 667

Human   773 SYL 775
            .||
  Fly   668 RYL 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CUL1	NP_001357589.1	Cullin	21..660	CDD:395716	156/657 (24%)
CUL1	NP_001357589.1	Cullin_Nedd8	706..767	CDD:402267	29/60 (48%)
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	202/781 (26%)
		CULLIN	362..500	CDD:214545	38/141 (27%)
		Cullin_Nedd8	606..661	CDD:287520	28/57 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1033
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0003709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.870