DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CUL1 and Cul4

DIOPT Version :9

Sequence 1:NP_001357589.1 Gene:CUL1 / 8454 HGNCID:2551 Length:776 Species:Homo sapiens
Sequence 2:NP_001163084.1 Gene:Cul4 / 35780 FlyBaseID:FBgn0033260 Length:821 Species:Drosophila melanogaster


Alignment Length:813 Identity:243/813 - (29%)
Similarity:391/813 - (48%) Gaps:116/813 - (14%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAK-------------SRYM--ELYTHVY 50
            |.:..:..|..:|:|.:....|  :..:...|::.:..|             .:|.  |||..|.
  Fly    88 MGAIHNSKPGDVKKIVIKNFKD--KPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVV 150

Human    51 NYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGE---DLMD 112
            |.|:  |:                         :..:||.:|||..:.::...:|..|   ..||
  Fly   151 NMCS--HK-------------------------MDAQLYAKLKELTEQHVKRNIKLKELTGGSMD 188

Human   113 ESV-LKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFR--- 173
            :.: |:.....|..:.....::..|..|::|.:|.:     ...::.|:.:.|     .|||   
  Fly   189 KLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQ-----NSTVHSIWDMGL-----DLFRIHF 243

Human   174 ----PLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFES 234
                .:.|:..:.:|.||||||.|.|::..|:..:|:...:              |.:|..|||.
  Fly   244 AQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCD--------------LQIYTSSFEE 294

Human   235 QFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKH 299
            :||..|.:.|..||...:|:..|.||::....||.||..|::.||..||:..|....|:.|:.:|
  Fly   295 KFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEH 359

Human   300 L-EIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDP 363
            | .|......:||:.::..||..:|.|:||:::|..||.....        ..|:|.|...:.||
  Fly   360 LTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFN--------GFIKKKGRTIVIDP 416

Human   364 ---KMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARY 425
               |..||.:||...|.:.:|.:.|.::..|..:|.:|...|||        |.::|..||:|:|
  Fly   417 EKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFIN--------QRANKPAELIAKY 473

Human   426 CDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMIS 490
            .|..|:..:|...:.|||.||:::||:|::|..||||:.||.|.|||||:...|||.|:|.||:|
  Fly   474 VDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLS 538

Human   491 KLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKH-LTNSEPL-DLDFSIQVLSSGSWPFQQSCTF 553
            ||||.||..:||||:.||:|:.:|:|:|..|:.| |:|:..: :||..:.:|:.|.||.......
  Fly   539 KLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYAPTEV 603

Human   554 ALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTED 618
            .:|.:.....|.|..||..:||||||.|...|....|..........|..|.||..:||.:|.:.
  Fly   604 TMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSLFQALVLLLFNDKP 668

Human   619 AYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLED-----ENANVDEVELKPDTLIKLYLGYKNK 678
            ..:.:::..:|.|:...|.:.||.|...:..|:..     |..:.|:.:...:        :.||
  Fly   669 VLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFNNE--------FTNK 725

Human   679 KLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFK 743
            ..|:.||.....|..:||:.|.:.:.:||:..|.|||||||||||.|.|..|:.|:..||:...|
  Fly   726 LFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLTFPVK 790

Human   744 PRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
            |  ..:||.|:.||:::|:||....::.|:|:|
  Fly   791 P--ADLKKRIESLIDRDYMERDKDNQNQYNYVA 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CUL1NP_001357589.1 Cullin 21..660 CDD:395716 196/675 (29%)
Cullin_Nedd8 706..767 CDD:402267 30/60 (50%)
Cul4NP_001163084.1 Cullin 124..721 CDD:279260 195/663 (29%)
CULLIN 503..644 CDD:214545 61/140 (44%)
Cullin_Nedd8 750..815 CDD:214883 30/66 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5647
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53685
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.830

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